Protein Alignment CTSD and CG17283

DIOPT Version :10

• Sequence 1: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_650621.1
• Gene: CG17283 / 42094
• FlyBaseID: FBgn0038505
• Length: 465
• Species: Drosophila melanogaster
• Alignment Length: 340
• Identity: 135/340 - (39%)
• Similarity: 188/340 - (55%)
• Gaps: 25/340 - (7%)

Human    71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNG 135
            |||..:.:|..::.||||.|.|||:.||||||:|||..|||  ..||..|.:|:..|||||||||
  Fly   142 LKNTANMEYTCKMNIGTPKQKFTVLPDTGSSNIWVPGPHCK--SKACKKHKQYHPAKSSTYVKNG 204

Human   136 TSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILG 200
            .||.|.|||||::|.|::|||.:           .|:.|..|.|...||:||.||:.:.||||||
  Fly   205 KSFAITYGSGSVAGVLAKDTVRI-----------AGLVVTNQTFAMTTKEPGTTFVTSNFDGILG 258

Human   201 MAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLS--YLN 263
            :.|..|:|:||..:..|:..:.::....|:..:.....:..||.::.|.:::..|.||.|  |..
  Fly   259 LGYRSIAVDNVKTLVQNMCSEDVITSCKFAICMKGGGSSSRGGAIIFGSSNTSAYSGSNSYTYTP 323

Human   264 VTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIP 328
            ||:|.|||..|..:.|  |.|......:||||:||||:..|.....::.|.||......||..:.
  Fly   324 VTKKGYWQFTLQDIYV--GGTKVSGSVQAIVDSGTSLITAPTAIYNKINKVIGCRATSSGECWMK 386

Human   329 CEKVSTLPAITLKLGGKGYKLSPEDYTLKV-SQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGR 392
            |.|  .:|..|..:.||.:.:......||| :..|:|:|:|....:    |..|: ||||.||..
  Fly   387 CAK--KIPDFTFVIAGKKFVVKGNKMKLKVRTNRGRTVCISAVTEV----PDEPV-ILGDAFIRH 444

Human   393 YYTVFDRDNNRVGFA 407
            :.|.||..|||:|||
  Fly   445 FCTEFDLANNRIGFA 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSD	NP_001900.1	A1_Propeptide	23..49	CDD:462326
		Cathepsin_D2	73..408	CDD:133157	133/338 (39%)
CG17283	NP_650621.1	Asp	149..460	CDD:394983	132/333 (40%)