Protein Alignment CTSD and CG10104

DIOPT Version :10

• Sequence 1: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_610961.1
• Gene: CG10104 / 36602
• FlyBaseID: FBgn0033933
• Length: 404
• Species: Drosophila melanogaster
• Alignment Length: 419
• Identity: 182/419 - (43%)
• Similarity: 256/419 - (61%)
• Gaps: 36/419 - (8%)

Human     5 SLLPLALCL---LAAPASA---LVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAV---- 59
            ||||:...|   ...|.|.   |.|:||.:|.|.|....::|..::.|..     ||::.|
  Fly     6 SLLPVLFILPVQFQHPVSCKLQLYRVPLRRFPSARHRFEKLGIRMDRLRL-----KYAEEVSHFR 65

Human    60 ----PAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH 120
                .||...|    |.||:||||:|.|.||||||.|.|:||||||||||||..|....:||.:|
  Fly    66 GEWNSAVKSTP----LSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVH 126

Human   121 HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQ 185
            ::|.:.:|:::...|..|.||||||||||:||.|||.|           .|:::..|.|.|||:.
  Fly   127 NRYFAKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTVRV-----------AGLEIRDQTFAEATEM 180

Human   186 PGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGT 250
            ||..|:|||||||.|:||..||:..:.|.|..:|:|.|:.:.|||.||||:.: :.||.:..||:
  Fly   181 PGPIFLAAKFDGIFGLAYRSISMQRIKPPFYAMMEQGLLTKPIFSVYLSRNGE-KDGGAIFFGGS 244

Human   251 DSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAI 315
            :..||.|:.:|:.|:.:|||||.:|.. |...|.||::|||.|:|||||.:..|.|:...:.::|
  Fly   245 NPHYYTGNFTYVQVSHRAYWQVKMDSA-VIRNLELCQQGCEVIIDTGTSFLALPYDQAILINESI 308

Human   316 GAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSG 380
            |..|...|::::||:.|..||.||..|||:.:.|...:|..:.....:.:|.|.|:.:|:|.|||
  Fly   309 GGTPSSFGQFLVPCDSVPDLPKITFTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSG 373

Human   381 PLWILGDVFIGRYYTVFDRDNNRVGFAEA 409
            |||||||||:|:|||.||.:.:|:|||:|
  Fly   374 PLWILGDVFLGKYYTEFDMERHRIGFADA 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSD	NP_001900.1	A1_Propeptide	23..49	CDD:462326	8/25 (32%)
		Cathepsin_D2	73..408	CDD:133157	157/334 (47%)
CG10104	NP_610961.1	pepsin_retropepsin_like	76..400	CDD:472175	158/340 (46%)