Protein Alignment CTSD and CG17134

DIOPT Version :10

• Sequence 1: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_609458.1
• Gene: CG17134 / 34494
• FlyBaseID: FBgn0032304
• Length: 391
• Species: Drosophila melanogaster
• Alignment Length: 410
• Identity: 181/410 - (44%)
• Similarity: 253/410 - (61%)
• Gaps: 30/410 - (7%)

Human     6 LLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPV--SKYS---QAVPAVTEG 65
            |:.|.|..:...|:.|.|:.|    .:.:..::..|||:   |:..|  ||||   :...:|:..
  Fly     5 LVLLVLVGIGHSAAKLNRVQL----QVNKNFTKTHGSVK---AEKTVLASKYSFLAETSFSVSSS 62

Human    66 PIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
            ...|.|.|.|:.:|||.|.||||.|.|.::|||||:||||||..|...:.||..|:||:|..|||
  Fly    63 GATENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSASST 127

Human   131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKF 195
            ||.||..|.|.||:|||||:||.|.|::           .|:.::.|.||||..:||.||:.|.|
  Fly   128 YVANGEEFAIEYGTGSLSGFLSNDIVTI-----------AGISIQNQTFGEALSEPGTTFVDAPF 181

Human   196 DGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLS 260
            .||||:|:..|:|:.|.|.|||::.|.|:|:.:.||||.|...|..||||:|||.||..|:|||:
  Fly   182 AGILGLAFSAIAVDGVTPPFDNMISQGLLDEPVISFYLKRQGTAVRGGELILGGIDSSLYRGSLT 246

Human   261 YLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEY 325
            |:.|:..||||..::.:: .:|..|| .||:||.||||||:..|:...|::.:.:||.. ..||.
  Fly   247 YVPVSVPAYWQFKVNTIK-TNGTLLC-NGCQAIADTGTSLIAVPLAAYRKINRQLGATD-NDGEA 308

Human   326 MIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFI 390
            .:.|.:||:||.:.|.:||..:.|:|.||.:||:|.|:|.|:|.|..|:    ....||||||||
  Fly   309 FVRCGRVSSLPKVNLNIGGTVFTLAPRDYIVKVTQNGQTYCMSAFTYME----GLSFWILGDVFI 369

Human   391 GRYYTVFDRDNNRVGFAEAA 410
            |::|||||:.|.|:|||..|
  Fly   370 GKFYTVFDKGNERIGFARVA 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSD	NP_001900.1	A1_Propeptide	23..49	CDD:462326	5/25 (20%)
		Cathepsin_D2	73..408	CDD:133157	160/334 (48%)
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:472175	159/333 (48%)