Protein Alignment CTSD and CG6508

DIOPT Version :10

• Sequence 1: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_609457.1
• Gene: CG6508 / 34493
• FlyBaseID: FBgn0032303
• Length: 423
• Species: Drosophila melanogaster
• Alignment Length: 411
• Identity: 166/411 - (40%)
• Similarity: 233/411 - (56%)
• Gaps: 40/411 - (9%)

Human     6 LLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKY-------SQAVPAVT 63
            ::||.|.||......|.|.|:.:..:..:|.:.|  ..|.::.   .:||       ||..
  Fly     8 IIPLFLLLLDHSMGQLRRTPITRQINQNKTHANV--KAEKILL---AAKYFLVDRQSSQTT---- 63

Human    64 EGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKS 128
                 :||.|..:.:|...:.||||||||.:.||||||:|||||:.|...:.||..|:||||..|
  Fly    64 -----QVLANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSSAS 123

Human   129 STYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAA 193
            |::|::|..|.|.||||||||:||.|||.:           .|:.:..|.|.||..:||..|:..
  Fly   124 SSHVEDGKGFSIQYGSGSLSGFLSTDTVDI-----------DGMVIRNQTFAEAIDEPGSAFVNT 177

Human   194 KFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGS 258
            .||||:|||:..|| ..|...|||:::|.||...:||.||.||..:|.|||::.||.|...|:|.
  Fly   178 IFDGIIGMAFASIS-GGVTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGC 241

Human   259 LSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQG 323
            ::|:.|:..||||...:.|:: .|:.|| .||:||.||||||:..|:...:.:.|.:.|.....|
  Fly   242 INYVPVSMPAYWQFTANSVKI-EGILLC-NGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDG 304

Human   324 EYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKV-SQAGKTLCLSGFMGMDIPPPSGPLWILGD 387
            |..:.|..:..||.:.|.:||..|.|:|:||..|| :...:|||||||..:.    ...||||||
  Fly   305 EAFVDCSSLCRLPNVNLNIGGTTYTLTPKDYIYKVQADNNQTLCLSGFTYLQ----GNLLWILGD 365

Human   388 VFIGRYYTVFDRDNNRVGFAE 408
            :|:|:.|||||....|:|||:
  Fly   366 IFLGKVYTVFDVGKERIGFAK 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSD	NP_001900.1	A1_Propeptide	23..49	CDD:462326	5/25 (20%)
		Cathepsin_D2	73..408	CDD:133157	148/335 (44%)
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:472175	148/335 (44%)