Protein Alignment CTSD and Bace

DIOPT Version :9

• Sequence 1: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Alignment Length: 403
• Identity: 177/403 - (43%)
• Similarity: 237/403 - (58%)
• Gaps: 45/403 - (11%)

Human    13 LLAAPASA-LVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPV-SKYS-QAVPAVTEGPIPEVLKNY 74
            ||||.||| |.|:|:.|..:..:|...|      |..|..: :||. .::.:|.|    |.|.|.
  Fly    10 LLAALASAELHRVPILKEQNFVKTRQNV------LAEKSYLRTKYQLPSLRSVDE----EQLSNS 64

Human    75 MDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFD 139
            |:..|||.|.||||.|.|.|:||:|||||||||..||  ..||..|::|:|..|||||.||.||.
  Fly    65 MNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCK--SDACLTHNQYDSSASSTYVANGESFS 127

Human   140 IHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYP 204
            |.||:|||:||||.|||.|           .|:.::.|.|.|:|.:||..|..|.|||||||||.
  Fly   128 IQYGTGSLTGYLSTDTVDV-----------NGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYE 181

Human   205 RISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAY 269
            .::|:.|.|.|.|::.|.|||.::|||||:||..:..||||:.||:|:..|.|:|:|:.::.:.|
  Fly   182 SLAVDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGY 246

Human   270 WQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVST 334
            ||..:....: .|.:|| :.|:||.||||||:|.|.:....|.:.:.    :..:..:.|..||:
  Fly   247 WQFTMAGSSI-DGYSLC-DDCQAIADTGTSLIVAPYNAYITLSEILN----VGEDGYLDCSSVSS 305

Human   335 LPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGF--MGMDIPPPSGPLWILGDVFIGRYYTVF 397
            ||.:|..:||..:.|.|..|.  :...|.  |:|.|  ||.|       .|||||||||:|||.|
  Fly   306 LPDVTFNIGGTNFVLKPSAYI--IQSDGN--CMSAFEYMGTD-------FWILGDVFIGQYYTEF 359

Human   398 DRDNNRVGFAEAA 410
            |..|||:|||..|
  Fly   360 DLGNNRIGFAPVA 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSD	NP_001900.1	A1_Propeptide	22..49	CDD:400357	6/26 (23%)
		Cathepsin_D2	73..408	CDD:133157	154/336 (46%)
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	155/339 (46%)
		Asp	68..371	CDD:278455	153/332 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.890