Protein Alignment CTSD and Bace

DIOPT Version :10

• Sequence 1: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_609235.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Alignment Length: 403
• Identity: 177/403 - (43%)
• Similarity: 237/403 - (58%)
• Gaps: 45/403 - (11%)

Human    13 LLAAPASA-LVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPV-SKYS-QAVPAVTEGPIPEVLKNY 74
            ||||.||| |.|:|:.|..:..:|...|      |..|..: :||. .::.:|.|    |.|.|.
  Fly    10 LLAALASAELHRVPILKEQNFVKTRQNV------LAEKSYLRTKYQLPSLRSVDE----EQLSNS 64

Human    75 MDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFD 139
            |:..|||.|.||||.|.|.|:||:|||||||||..||  ..||..|::|:|..|||||.||.||.
  Fly    65 MNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCK--SDACLTHNQYDSSASSTYVANGESFS 127

Human   140 IHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYP 204
            |.||:|||:||||.|||.|           .|:.::.|.|.|:|.:||..|..|.|||||||||.
  Fly   128 IQYGTGSLTGYLSTDTVDV-----------NGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYE 181

Human   205 RISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAY 269
            .::|:.|.|.|.|::.|.|||.::|||||:||..:..||||:.||:|:..|.|:|:|:.::.:.|
  Fly   182 SLAVDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGY 246

Human   270 WQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVST 334
            ||..:....: .|.:|| :.|:||.||||||:|.|.:....|.:.:.    :..:..:.|..||:
  Fly   247 WQFTMAGSSI-DGYSLC-DDCQAIADTGTSLIVAPYNAYITLSEILN----VGEDGYLDCSSVSS 305

Human   335 LPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGF--MGMDIPPPSGPLWILGDVFIGRYYTVF 397
            ||.:|..:||..:.|.|..|.  :...|.  |:|.|  ||.|       .|||||||||:|||.|
  Fly   306 LPDVTFNIGGTNFVLKPSAYI--IQSDGN--CMSAFEYMGTD-------FWILGDVFIGQYYTEF 359

Human   398 DRDNNRVGFAEAA 410
            |..|||:|||..|
  Fly   360 DLGNNRIGFAPVA 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSD	NP_001900.1	A1_Propeptide	23..49	CDD:462326	6/25 (24%)
		Cathepsin_D2	73..408	CDD:133157	154/336 (46%)
Bace	NP_609235.1	pepsin_retropepsin_like	59..369	CDD:472175	155/339 (46%)