Protein Alignment CTSD and CG31661

DIOPT Version :10

• Sequence 1: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_722707.1
• Gene: CG31661 / 33330
• FlyBaseID: FBgn0051661
• Length: 393
• Species: Drosophila melanogaster
• Alignment Length: 390
• Identity: 136/390 - (34%)
• Similarity: 191/390 - (48%)
• Gaps: 61/390 - (15%)

Human    29 FTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFT 93
            ||.: ||::.|..:.|.  .||.|              |.|.|.|..|..::|.:.:|  .|.||
  Fly    55 FTPL-RTVNAVNVTSES--GKGVV--------------ITEPLINSYDTNFFGVVSVG--DQSFT 100

Human    94 VVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
            :.||||||:.||||.||:.....|. :..:....|.::..:||.|.|.|||||:.|.::.|.|
  Fly   101 MQFDTGSSDFWVPSSHCRFCIKTCG-NKFFRKSNSKSFRSSGTPFSITYGSGSVKGIVASDNV-- 162

Human   159 PCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKL 223
                     ..|.:|::.|..|..    .|:...:.||||.|.|:.::|:...:|.|..::.|:|
  Fly   163 ---------GFGDLKIQNQGIGLV----NISDSCSVFDGIAGFAFQQLSMTKSVPSFQQMIDQQL 214

Human   224 VDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEV-ASGLTLCK 287
            |:|.||||:|.  ..:..||.::|||::|..|.|.|:|.|||...||...||.:.| ..|....:
  Fly   215 VEQPIFSFHLK--SGSSDGGSMILGGSNSSLYYGPLTYTNVTEAKYWSFKLDFIAVHGKGSRSSR 277

Human   288 EGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGE-------YMIPCEKVSTLPAITLKLGGK 345
            .|.:||:||||||:||||.||..:.|.|||      |       |.:.||.:..||.|...:.||
  Fly   278 TGNKAIMDTGTSLIVGPVLEVLYINKDIGA------EHNKTYNLYTVACESIPQLPIIVFGIAGK 336

Human   346 GYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSG-PLWILGDVFIGRYYTVFDRDNNRVGFAEA 409
            .:.:.|..|.::..    ..|.|.||.|     .| ..|||||.|:...|..||....|:|.|.|
  Fly   337 EFFVKPHTYVIRYD----NFCFSAFMDM-----LGLQYWILGDAFMRENYVEFDWARRRMGIAPA 392

Human   410  409
              Fly   393  392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSD	NP_001900.1	A1_Propeptide	23..49	CDD:462326	6/19 (32%)
		Cathepsin_D2	73..408	CDD:133157	122/343 (36%)
CG31661	NP_722707.1	Asp	88..392	CDD:394983	121/338 (36%)