Protein Alignment CTSD and Pgcl

DIOPT Version :10

• Sequence 1: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_525030.1
• Gene: Pgcl / 30984
• FlyBaseID: FBgn0011822
• Length: 407
• Species: Drosophila melanogaster
• Alignment Length: 413
• Identity: 164/413 - (39%)
• Similarity: 224/413 - (54%)
• Gaps: 47/413 - (11%)

Human     2 QPSSLLPLA--LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTE 64
            |..||:.||  :.|:....|.|.|||:.|..:.:|:...:... .|.:.:    ||::...|  .
  Fly     5 QIKSLVFLAGLIVLVGEANSTLRRIPIQKSPNFKRSHKNIVAE-RDFVQQ----KYNRQYTA--N 62

Human    65 GPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSS 129
            |...|.|.||.:.||||.|.||||.|.|.|.|||||||||||...|  :..||..|..:..:|||
  Fly    63 GYPMEHLSNYDNFQYYGNISIGTPGQDFLVQFDTGSSNLWVPGSSC--ISTACQDHQVFYKNKSS 125

Human   130 TYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAK 194
            |||.|||:|.|.||:||:|||||.|.|           ...|:.::.|.|||.|.:.|..|:.|.
  Fly   126 TYVANGTAFSITYGTGSVSGYLSVDCV-----------GFAGLTIQSQTFGEVTTEQGTNFVDAY 179

Human   195 FDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQP--GGELMLGGTDSKYYKG 257
            |||||||.:|.::|:.|.|.|.|:|||.||...:|||:| ||..:..  ||||:|||:|...|.|
  Fly   180 FDGILGMGFPSLAVDGVTPTFQNMMQQGLVQSPVFSFFL-RDNGSVTFYGGELILGGSDPSLYSG 243

Human   258 SLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGP---VDEVRELQKAIGAVP 319
            ||:|:||.:.|||:...|.::|  |.|......:||.||||||::.|   .|::.:|..|
  Fly   244 SLTYVNVVQAAYWKFQTDYIKV--GSTSISTFAQAIADTGTSLIIAPQAQYDQISQLFNA----- 301

Human   320 LIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWI 384
              ..|.:..|...| .|.:.:.:.|..:|:..:.|.::...         |..:.|...:...||
  Fly   302 --NSEGLFECSSTS-YPDLIININGVDFKIPAKYYIIEEED---------FCSLAIQSINQDFWI 354

Human   385 LGDVFIGRYYTVFDRDNNRVGFA 407
            :||||:||.||.||..|.|:|||
  Fly   355 MGDVFLGRIYTEFDVGNQRLGFA 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSD	NP_001900.1	A1_Propeptide	23..49	CDD:462326	6/25 (24%)
		Cathepsin_D2	73..408	CDD:133157	144/340 (42%)
Pgcl	NP_525030.1	Asp	76..379	CDD:394983	142/335 (42%)