Protein Alignment CTSB and CG5367

DIOPT Version :9

• Sequence 1: NP_001371643.1
• Gene: CTSB / 1508
• HGNCID: 2527
• Length: 339
• Species: Homo sapiens
• Sequence 2: NP_609387.1
• Gene: CG5367 / 34401
• FlyBaseID: FBgn0032228
• Length: 338
• Species: Drosophila melanogaster
• Alignment Length: 383
• Identity: 88/383 - (22%)
• Similarity: 144/383 - (37%)
• Gaps: 116/383 - (30%)

Human     1 MWQL--WASLC---CLLVLAN--------ARSRPSFHPLS-----------DELVNY-------- 33
            ||:|  :..||   |.:|.:|        |..:..|....           ||:.:|
  Fly     1 MWKLIFFGCLCGLNCQIVTSNLSEGNSSSANCKSEFEKFKNNNNRKYLRTYDEMRSYKAFEENFK 65

Human    34 -VNKRNTTWQAGHNFYNV------DMS---YLK---RL-----------CGTFLGGPKPPQRVMF 74
             :.:.|..::.|...:.:      |||   |||   ||           ....:|.|     :|
  Fly    66 VIEEHNQNYKEGQTSFRLKPNIFADMSTDGYLKGFLRLLKSNIEDSADNMAEIVGSP-----LM- 124

Human    75 TEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLL 139
               ..:|.|.|.|.:....|...::    |||||:||...|:|..::...|...:|  :|.:.::
  Fly   125 ---ANVPESLDWRSKGFITPPYNQL----SCGSCYAFSIAESIMGQVFKRTGKILS--LSKQQIV 180

Human   140 TCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDT 204
            .|..|....||.||......::...    :||:....                 ..|....:|
  Fly   181 DCSVSHGNQGCVGGSLRNTLSYLQS----TGGIMRDQ-----------------DYPYVARKG-- 222

Human   205 PKCSKICEPGYSPTYKQDKHYGYNSYSV--SNSEKDIMAEIYKNGPVEGAFSVYSD---FLLYKS 264
             ||..:  |..|..       ...|:::  ...|:.|.|.:...|||  |.|:.:.   |.||..
  Fly   223 -KCQFV--PDLSVV-------NVTSWAILPVRDEQAIQAAVTHIGPV--AISINASPKTFQLYSD 275

Human   265 GVYQH-VTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGI 321
            |:|.. :.......||:.::|:|.:    ||::.|.|..:||:||:.:|.:|.:.|||
  Fly   276 GIYDDPLCSSASVNHAMVVIGFGKD----YWILKNWWGQNWGENGYIRIRKGVNMCGI 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSB	NP_001371643.1	Propeptide_C1	26..65	CDD:400445	13/81 (16%)
		Peptidase_C1A_CathepsinB	81..328	CDD:239111	62/247 (25%)
CG5367	NP_609387.1	Inhibitor_I29	36..96	CDD:285458	9/59 (15%)
		Peptidase_C1A	128..336	CDD:239068	62/247 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820