DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHADL and Fili

DIOPT Version :9

Sequence 1:	XP_011528235.1	Gene:	CHADL / 150356	HGNCID:	25165	Length:	830	Species:	Homo sapiens
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	641	Identity:	151/641 - (23%)
Similarity:	224/641 - (34%)	Gaps:	165/641 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   135 LDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALD 199
            |||..|:::.:.:..|:....|..|:|....|..:.:.||:||..||||:|:.|.:..:...||.
  Fly   101 LDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALS 165

Human   200 GLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAM-------------------- 244
            .|.||..|:|..|.:..|....|..:..|..|...:|.|:.:||.
  Fly   166 DLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEF 230

Human   245 ----AFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLEL 305
                :|:||..:..|.:..|.:|.|...|..||.:|:.|.|..|.|..:|...||:...|..|.|
  Fly   231 VRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNL 295

Human   306 GHNPLTYAGEEDGLALPGLRELLLDG-GALQALGPRAFAHCPRLHTLDL---------------- 353
            |.|..:.......|.|..||||.|.. ..||.:..|||.....|.||.|
  Fly   296 GGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQG 360

Human   354 ---------RGNQLDTLPPLQGP-GQLRRLRLQGNPLWCGCQARPLLEWLARARVRS-DGACQGP 407
                     :.|.|.||...|.| .||::|.|..|||.|.|.    |.||.|....: :|...|.
  Fly   361 NPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCS----LLWLWRLVTGNFEGVDPGM 421

Human   408 RRLRGEALDALRPWDLRCPGDAAQE--EEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVC 470
            ....|.|:.||           |:|  :|||.:.|.|           ....:..||    |...
  Fly   422 EHAAGGAVAAL-----------AKEADDEELADEATA-----------VASTDDGVA----ALAA 460

Human   471 VPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLG------------------ 517
            ....:|.      :.|:....||..:|.....|....:.|.....:|
  Fly   461 YIAEQHI------VNALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMS 519

Human   518 --------HLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLER 574
                    |:|::   .|.:......|:.|:..|.||                       .:::|
  Fly   520 EGEITCPAHIVTV---VCAVITCLLVAMIGISVLYYL-----------------------RFVKR 558

Human   575 NRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAREL 639
            .|.|......:|...|:.::|  |..:....||.||  ..:......||.:..:.: .|......
  Fly   559 RRKLLHERGPMRTSKSIINVH--DRILQGHNPGGLG--LGMSMTLGGGNHVNGLGM-TLNYPHHA 618

Human   640 EKLHLDRNQLREVPTGALEG----------LPALLELQLS--------GNPLRALR 677
            :.|....:..:.:|..:..|          ||.|.:|:|.        .|..|||:
  Fly   619 QTLQAHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKLELERYLAAQTIANEYRALK 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHADL	XP_011528235.1	leucine-rich repeat	132..155	CDD:275380	5/19 (26%)
		LRR_RI	<133..358	CDD:238064	75/272 (28%)
		LRR_8	133..214	CDD:290566	27/78 (35%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..203	CDD:275380	9/22 (41%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR_8	228..286	CDD:290566	20/81 (25%)
		leucine-rich repeat	228..251	CDD:275380	9/46 (20%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		LRR_8	322..380	CDD:290566	25/84 (30%)
		leucine-rich repeat	324..347	CDD:275380	10/23 (43%)
		LRR_4	346..>380	CDD:289563	15/59 (25%)
		LRRNT	463..497	CDD:214470	5/33 (15%)
		leucine-rich repeat	478..494	CDD:275380	2/15 (13%)
		LRR_RI	492..671	CDD:238064	36/222 (16%)
		leucine-rich repeat	495..518	CDD:275380	4/48 (8%)
		LRR_8	518..577	CDD:290566	9/58 (16%)
		leucine-rich repeat	519..542	CDD:275380	4/22 (18%)
		leucine-rich repeat	543..566	CDD:275380	3/22 (14%)
		LRR_8	565..625	CDD:290566	13/59 (22%)
		leucine-rich repeat	567..590	CDD:275380	4/22 (18%)
		leucine-rich repeat	591..614	CDD:275380	6/22 (27%)
		leucine-rich repeat	615..638	CDD:275380	3/22 (14%)
		LRR_8	637..698	CDD:290566	12/59 (20%)
		leucine-rich repeat	639..662	CDD:275380	4/32 (13%)
		leucine-rich repeat	663..687	CDD:275380	7/23 (30%)
		LRR_8	686..745	CDD:290566
		leucine-rich repeat	688..712	CDD:275380
		LRR_4	711..>744	CDD:289563
		LRRCT	743..791	CDD:214507
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378
		leucine-rich repeat	98..121	CDD:275380	5/19 (26%)
		LRR_8	120..180	CDD:404697	22/59 (37%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	55/192 (29%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	10/23 (43%)
		LRR_8	337..397	CDD:404697	15/59 (25%)
		leucine-rich repeat	339..360	CDD:275380	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010