DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTNND2 and p120ctn

DIOPT Version :9

Sequence 1:	XP_005248308.1	Gene:	CTNND2 / 1501	HGNCID:	2516	Length:	1250	Species:	Homo sapiens
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	878	Identity:	318/878 - (36%)
Similarity:	448/878 - (51%)	Gaps:	207/878 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   322 SSAGLS--PIRVTSPPTVQSTISSSPIHQLSSTIGTYAT-----------LSPTKRLVHASEQYS 373
            |:||.|  |:.:|.|..|.:....:| |...:.|.|.:|           |:.|.|.|.|. ||.
  Fly    47 SAAGYSSTPLYITKPTGVGAITKVAP-HCSQNKIETNSTDNSIPDIENHPLATTVRYVQAG-QYE 109

Human   374 KHSQELYATATLQRPGSLAAGSRAS----------YSSQHGHLGPELRALQSPEHHIDPI----Y 424
            ..|:  |..|      .|..|..:.          |:|...:.|     :|:....|.|.    :
  Fly   110 DTSE--YGVA------GLTCGIDSEYTAEAVVPYCYTSDANYTG-----IQNTTSSIKPFSGRPF 161

Human   425 EDRVYQKPPMRSLSQSQGDPLPPAHTGTYRTSTAPSSP-----GVDSVPLQRTGSQHGPQNAAAA 484
            .|.:           :..:.:..:...|:::|.....|     .:::|| ||..
  Fly   162 NDNI-----------NGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVP-QRLE----------- 203

Human   485 TFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRD 549
              ::..|..|..::.....|                                          |||
  Fly   204 --EKDDYIEGSENDICSTMR------------------------------------------WRD 224

Human   550 PELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACG 614
            |.|.|||..|.:...::::||||||||||:.|:..|...|..|||..||.||.:...|:|::|||
  Fly   225 PNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACG 289

Human   615 ALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDAL 679
            |||||.||:.||:||..:||.|||.|||.||.::.:.|::|||||||||:|||:.||..||.:||
  Fly   290 ALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEAL 354

Human   680 AVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALL 744
            ..:..:||.|||||:.....     :...|.|.|||:|.|||||||||.||..:|.|:.|.:.||
  Fly   355 VAVVCSVIKPHSGWDAVCCG-----ETCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLL 414

Human   745 YVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELD--------GLLCGEANGK 801
            ||:::::..:.|.:||||||||||||||||.       |.:.....|        .::...:.|
  Fly   415 YVVRTSIEKNNIGNKTVENCVCILRNLSYRC-------QEVDDPNYDKHPFITPERVIPSSSKG- 471

Human   802 DAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPP----------KGIQMLWHPSIVKPYLTLLSE 856
              |:.||:|..||||::.:. |.:......|:..          ||.:.||.|.:|:.||:||..
  Fly   472 --ENLGCFGTNKKKKEANNS-DALNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQS 533

Human   857 CSNPDTLEGAAGALQNLAAGSWKGWAEDVAGMAYALRSLPEGAPCLPQWSVYIRAAVRKEKGLPI 921
            ||||:|||.||||:|||:|..|                         |.|:.|||.|||||||||
  Fly   534 CSNPETLEAAAGAIQNLSACYW-------------------------QPSIDIRATVRKEKGLPI 573

Human   922 LVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGN--NSNNTASKAMSDDT 984
            ||||||::.|||||||||||||:|:|.|||||||||||||||.:||.||  :..||     ||||
  Fly   574 LVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNT-----SDDT 633

Human   985 VTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRS 1049
            :|||..|::|||.||.|.:::|.|:|||::|:.|:|.| :|::..|:|.|||||.:|||:.:||.
  Fly   634 ITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRK-EKYTSCVLKFASQVLYTMWQHNELRD 697

Human  1050 LYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTD 1114
            :|||:||.:..||:          :.:::..||..||..|   |.:.:.|.:       .:.:|.
  Fly   698 VYKKNGWKEQDFVS----------KHFTAHNTPPSSPNNV---NNTLNRPMA-------SQGRTR 742

Human  1115 YE----CTGSNATY--HGAKGEHTSRKDAMTAQ 1141
            ||    ..|::..|  :.:.|...|.:.||.::
  Fly   743 YEDRTIQRGTSTLYSANDSSGAVMSNESAMLSE 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTNND2	XP_005248308.1	ARM	544..666	CDD:237987	65/121 (54%)
		armadillo repeat	552..577	CDD:293788	12/24 (50%)
		armadillo repeat	585..621	CDD:293788	19/35 (54%)
		armadillo repeat	629..664	CDD:293788	20/34 (59%)
		armadillo repeat	671..722	CDD:293788	20/50 (40%)
		Arm	834..875	CDD:278915	24/50 (48%)
		armadillo repeat	838..875	CDD:293788	22/36 (61%)
		armadillo repeat	910..944	CDD:293788	29/33 (88%)
		ARM	911..1043	CDD:237987	84/133 (63%)
		armadillo repeat	951..997	CDD:293788	29/47 (62%)
		armadillo repeat	1003..1038	CDD:293788	15/34 (44%)
		CAF20	<1054..1113	CDD:293657	11/58 (19%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	61/113 (54%)
		armadillo repeat	227..252	CDD:293788	12/24 (50%)
		armadillo repeat	260..296	CDD:293788	19/35 (54%)
		armadillo repeat	304..339	CDD:293788	20/34 (59%)
		ARM	307..442	CDD:237987	73/139 (53%)
		armadillo repeat	347..392	CDD:293788	19/49 (39%)
		armadillo repeat	515..556	CDD:293788	24/65 (37%)
		ARM	516..643	CDD:237987	88/156 (56%)
		armadillo repeat	562..596	CDD:293788	29/33 (88%)
		armadillo repeat	601..641	CDD:293788	28/44 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5321
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55574
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1931
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	1	1.000	-	-		FOG0006320
OrthoInspector	1	1.000	-	-		otm41407
orthoMCL	1	0.900	-	-		OOG6_104813
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.900