DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTNND2 and ctnnd2

DIOPT Version :9

Sequence 1:	XP_005248308.1	Gene:	CTNND2 / 1501	HGNCID:	2516	Length:	1250	Species:	Homo sapiens
Sequence 2:	XP_031759534.1	Gene:	ctnnd2 / 100127641	XenbaseID:	XB-GENE-5888637	Length:	1325	Species:	Xenopus tropicalis

Alignment Length:	1360	Identity:	1102/1360 - (81%)
Similarity:	1145/1360 - (84%)	Gaps:	145/1360 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFARKP-PGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQELQFER 64
            |||:.| ..:.|.||||||||| |.|||||||||.||||||||||||||||||||||||||||||
Frog     1 MFAKNPGESSTPSGAMPVPDQP-SCSEKTSSLSPILNTSNGDGSETETTSAILASVKEQELQFER 64

Human    65 LTRELEAERQIVASQLERCKLGSETGSMSSMSSAEEQFQWQSQDGQKDIEDELTTGLELVDSCIR 129
            ||||||||||||||||||||||||||||||:||.||||:||:|||||||||||||||||||||||
Frog    65 LTRELEAERQIVASQLERCKLGSETGSMSSISSTEEQFRWQTQDGQKDIEDELTTGLELVDSCIR 129

Human   130 SLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGETTPSQLPARGTQ 194
            ||||||||||||||:.|||||||||||||||||||||||.:||||||||||||::..|.|:|..|
Frog   130 SLQESGILDPQDYSSSERPSLLSQSALQLNSKPEGSFQYSSSYHSNQTLALGESSALQFPSRSNQ 194

Human   195 ARATGQSFSQGTTSRAGHLAGPEPAPP-PPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSST 258
            ||:..||:||||||||.|.:|.||:.. .....||.|.||.||||||||   :..::.|||||||
Frog   195 ARSAIQSYSQGTTSRAAHSSGSEPSQSHAASQSRESFVPSHGSAFHLPD---SQHSSTLYYSSST 256

Human   259 LPAPPRGGSPLAAPQGGSPTKLQRGGSAPEGATYA-APRGSSPKQSPSRLAKSYSTSSPINIVVS 322
            ||| .|..|||:..|.||||||||.|||.|...|: ..|.|||||||||||||||||||||||||
Frog   257 LPA-QRVSSPLSMQQVGSPTKLQRVGSASESTGYSTTQRVSSPKQSPSRLAKSYSTSSPINIVVS 320

Human   323 SAGLSP--IRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATL 385
            ||||||  :|||||||:||.|||||:|.|||||||||||||||||||.|:||:||| ||||||||
Frog   321 SAGLSPSSVRVTSPPTIQSNISSSPLHSLSSTIGTYATLSPTKRLVHTSDQYNKHS-ELYATATL 384

Human   386 QRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHT 450
            ||||||||||||||:|||.|||.|:|:|||||||||||||||||||||||||||||||.|.||||
Frog   385 QRPGSLAAGSRASYTSQHSHLGSEIRSLQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDTLLPAHT 449

Human   451 GTYRTST--------------------------APSSPGVDSVPLQRTGSQHGPQNAAAATFQRA 489
            .:|||:|                          ||||||||||||||||||||.|| |..|||||
Frog   450 SSYRTNTDTVPDFDPMSLIFKSVVPDFSVGDLRAPSSPGVDSVPLQRTGSQHGTQN-ATGTFQRA 513

Human   490 SYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPE 554
            |||||||:|||||||||||||||:|||||||||:|||||||||||||||||||||||||||||||
Frog   514 SYAAGPAANYADPYRQLQYCPSVDSPYSKSGPAIPPEGTLARSPSIDSIQKDPREFGWRDPELPE 578

Human   555 VIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNL 619
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   579 VIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNL 643

Human   620 VYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELV------------TGVLWNLSSCDALKM 672
            ||||||||||||||||||||||||||||||||||||||            |||||||||||||||
Frog   644 VYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTACNTNWGVRIQTGVLWNLSSCDALKM 708

Human   673 PIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECD 737
            ||||||||||||||||||||||||.||||||:|||||||||||||||||||||||||||||||||
Frog   709 PIIQDALAVLTNAVIIPHSGWENSILQDDRKVQLHSSQVLRNATGCLRNVSSAGEEARRRMRECD 773

Human   738 GLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKD 802
            |||||||||||||||||:||||||||||||||||||||||||||||.|||||||||||||.||||
Frog   774 GLTDALLYVIQSALGSSDIDSKTVENCVCILRNLSYRLAAETSQGQQMGTDELDGLLCGENNGKD 838

Human   803 AESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAA 867
            .|||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
Frog   839 TESSGCWGKKKKKKKSQDQWDGVGPLPDCADPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAA 903

Human   868 GALQNLAAGSWKGWAEDVAGMAYALRSLPEGAPCLPQWSVYIRAAVRKEKGLPILVELLRIDNDR 932
            ||||||||||||                         |||||||||||||||||||||||:||||
Frog   904 GALQNLAAGSWK-------------------------WSVYIRAAVRKEKGLPILVELLRVDNDR 943

Human   933 VVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTASKAMSDDTVTAVCCTLHEVIT 997
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||:|||||||||
Frog   944 VVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNSASKAMSDDTVTAICCTLHEVIT 1008

Human   998 KNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKK--------- 1053
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog  1009 KNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKQDAPGLKVN 1073

Human  1054 ---------------------------------DGWSQYHFVASSSTIERDRQRPYSSSRTPSIS 1085
                                             ||||||||||||||||||||||||||||||||
Frog  1074 EERGYTPTLQSEPDNALYTLTQGQATRNNSQIQDGWSQYHFVASSSTIERDRQRPYSSSRTPSIS 1138

Human  1086 PVRVSPNNRSASAPASPREMISLKERKTDYECTGSNATYHGAKGEHTSRKDAMTAQNTGISTLYR 1150
            |||:|||||||||||||||||||||||||||..|||||:   |||||||||.|||||||.|||||
Frog  1139 PVRMSPNNRSASAPASPREMISLKERKTDYESPGSNATF---KGEHTSRKDTMTAQNTGTSTLYR 1200

Human  1151 NSYGAPAEDIKHNQV-------------------------SAQPVPQEPSRKDYETYQPFQNSTR 1190
            ||||.||||||||||                         |.|||||:.|||||:||||||||||
Frog  1201 NSYGTPAEDIKHNQVASIVLSLPEDRSRVGVSDPATSLNISTQPVPQDSSRKDYDTYQPFQNSTR 1265

Human  1191 NYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV 1250
            |||:||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
Frog  1266 NYDDSFFEDQVHHRPPASEYNMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV 1325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTNND2	XP_005248308.1	ARM	544..666	CDD:237987	121/133 (91%)
		armadillo repeat	552..577	CDD:293788	24/24 (100%)
		armadillo repeat	585..621	CDD:293788	35/35 (100%)
		armadillo repeat	629..664	CDD:293788	34/46 (74%)
		armadillo repeat	671..722	CDD:293788	48/50 (96%)
		Arm	834..875	CDD:278915	40/40 (100%)
		armadillo repeat	838..875	CDD:293788	36/36 (100%)
		armadillo repeat	910..944	CDD:293788	32/33 (97%)
		ARM	911..1043	CDD:237987	128/131 (98%)
		armadillo repeat	951..997	CDD:293788	43/45 (96%)
		armadillo repeat	1003..1038	CDD:293788	34/34 (100%)
		CAF20	<1054..1113	CDD:293657	57/58 (98%)
ctnnd2	XP_031759534.1	armadillo repeat	576..601	CDD:293788	24/24 (100%)
		ARM	605..645	CDD:214547	39/39 (100%)
		armadillo repeat	609..645	CDD:293788	35/35 (100%)
		Arm	649..702	CDD:395413	40/52 (77%)
		armadillo repeat	653..700	CDD:293788	34/46 (74%)
		armadillo repeat	715..758	CDD:293788	40/42 (95%)
		Arm	870..911	CDD:395413	40/40 (100%)
		armadillo repeat	874..911	CDD:293788	36/36 (100%)
		ARM	921..956	CDD:214547	33/34 (97%)
		armadillo repeat	921..955	CDD:293788	32/33 (97%)
		armadillo repeat	962..1008	CDD:293788	43/45 (96%)
		ARM	1010..1054	CDD:214547	43/43 (100%)
		armadillo repeat	1014..1049	CDD:293788	34/34 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	897	1.000	Domainoid score	I905
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55574
Inparanoid	1	1.050	2101	1.000	Inparanoid score	I599
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38506
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	1	1.000	-	-		FOG0006320
OrthoInspector	1	1.000	-	-		oto151804
Panther	1	1.100	-	-	LDO	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080