DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIK1 and AMPKalpha

DIOPT Version :10

Sequence 1:NP_775490.2 Gene:SIK1 / 150094 HGNCID:11142 Length:783 Species:Homo sapiens
Sequence 2:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster


Alignment Length:451 Identity:171/451 - (37%)
Similarity:249/451 - (55%) Gaps:57/451 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     4 MSEFSADPAGQGQGQQKPL-RVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSN 67
            |...:|:....|....:|| ::|.|.:..|||.|.|..||:..|::|:.:||:||:::.::.|.:
  Fly     4 MRAAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLD 68

Human    68 -LEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFW 131
             :.||.||:|.:||..||||||||||:.|...::::.|:...||:|||:..:|.|.|::||:.|.
  Fly    69 VVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQ 133

Human   132 QILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFE 196
            ||:|.|:|||.|.|||||||.||||||.||.:|:||||..|....||.|.|.||||.||||||..
  Fly   134 QIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVIS 198

Human   197 GKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVV 261
            ||.|.||::||||.||:||.|:||:||||..::|||.:::..|.|.||.::::...:|:.:||.|
  Fly   199 GKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQV 263

Human   262 DPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALG-IMQTLGVDRQRTVES 325
            ||.:|..|.:|::|.|.:.:  ||....|  |:....||:  .|..|:. :....||.......|
  Fly   264 DPLKRANIEEIKKHEWFQKD--LPAYLFP--SSIEQDSNV--IDTYAVAEVCTKFGVKETEVHNS 322

Human   326 -LQNSSYNHFAAIYYLLLE----------RLKEYRNAQCA--RPGPARQPRPRS----------- 366
             |....::..|..|:|:::          ::.|..|...|  .|.|...|.|:|           
  Fly   323 LLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATV 387

Human   367 ------SDLSGLEVPQEGL------STDPFRPALLCPQPQTLVQSVLQAEM-DCELQSSLQ 414
                  |..||...|...:      ||.|.|     |.|:.:      |.| |.:|..|:|
  Fly   388 TVGGGTSASSGTATPVPPVAGGTPSSTIPIR-----PHPERI------APMRDRQLAMSVQ 437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIK1NP_775490.2 STKc_SIK 26..278 CDD:270973 125/252 (50%)
UBA_SIK1 300..349 CDD:270591 11/60 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..377 10/42 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..477
RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305|PubMed:29211348 583..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 619..643
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 126/254 (50%)
UBA_AID_AMPKalpha 297..360 CDD:270521 13/64 (20%)
AMPKA_C 457..580 CDD:213378
Blue background indicates that the domain is not in the aligned region.

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