Protein Alignment SIK1 and Nuak

DIOPT Version :10

• Sequence 1: NP_775490.2
• Gene: SIK1 / 150094
• HGNCID: 11142
• Length: 783
• Species: Homo sapiens
• Sequence 2: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Alignment Length: 901
• Identity: 235/901 - (26%)
• Similarity: 359/901 - (39%)
• Gaps: 217/901 - (24%)

Human     9 ADPAGQGQGQ-------------------QKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVA 54
            |.|:|..|.|                   :|.||..| ||.:.||:|.:..|:|..::.|..:||
  Fly    34 AHPSGIPQDQIDNIMSGIANTGNVKMNNHRKKLRQRF-DIIKKLGQGTYGKVQLGINKETGQEVA 97

Human    55 IKIIDKTRLDS-SNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSN 118
            ||.|.|.:::: ::|.:|.||||:|..::||:||.:|:|.|.::.:.:|.|||..||::|||:..
  Fly    98 IKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYLSER 162

Human   119 GHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTW 183
            ..|:|.|||:.|.|:.:||.|||.|.|.|||||.||:|||...:.|:||||..|.:.....|.|:
  Fly   163 KVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTF 227

Human   184 CGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMS 248
            ||||.||:||:.||..|:||::|.|||||:||.||.||:||||.|...|.:::.:|.:..|...|
  Fly   228 CGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPS 292

Human   249 QDCESLIRRMLVVDPARRITIAQIRQHRWMRAE---PCLPGPACPAFSAHSYTSNLGDYDEQALG 310
            : ..:|||.||.|.|.:|.:|.||..|.|:...   .||           ....:|.:.....|.
  Fly   293 R-ASTLIRDMLTVCPRKRASIEQICSHWWVNENDNVSCL-----------DLAEDLANQTPVRLD 345

Human   311 IMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYR-----------NAQCAR--------- 355
            ::.:| .....|.:.|...|....||......||:....           |.:..|
  Fly   346 VLLSL-TPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMVAAG 409

Human   356 ------PGPARQPRPRSSDLSGLEVPQEGLSTD---------PFRP-----------ALLCPQPQ 394
                  |.|.|...|..|.:......|..:||:         ..:|           |.|...|.
  Fly   410 GEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFVISKDGAPLTEAPP 474

Human   395 TLVQ---SVLQAEMDCELQSSLQWPLFFPVDASCSG---------VFRPRPVSPSSLLDTAISEE 447
            |:::   ::::||....:...:..|.:...|....|         ...|.|..|:   .|.::.:
  Fly   475 TIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLMGTATTPAPAPPA---PTPVARQ 536

Human   448 ARQGP-----GLEEEQDTQESLPSSTGRRHT---LAEVSTRLSPLTAPCIVVSP----------- 493
            ..:|.     ...||:|..:.:.....:..|   :..::...|...||...|:|
  Fly   537 PTRGKLDAVVETPEEKDATKVIKKFVNKHKTADLVNAINESASKAAAPVSAVAPPPFVRKCSLQD 601

Human   494 -ST--------------------------TASPAE--------GTSSDSC---LTFSASKSPAGL 520
             ||                          .|:|.|        |.|..|.   ....|:..||..
  Fly   602 ESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPGVSVGSFKKEFEKKATNPPAAE 666

Human   521 SGTPA---TQGLLGACSPVRLASPFLGSQSATPVL--QAQGGLGGAVLLPVSFQEGRRASDTSLT 580
            ..||.   .|..:.|.:.....:..|.:...:||:  ..:|......:..:|..|.||:.:.|:.
  Fly   667 GPTPGELRAQEQVAAAAAAAQEAETLSTPPPSPVVAQSLEGSDSKNSVASISLDEARRSMENSIA 731

Human   581 QGLKAFRQ------QLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGL--------SPFHAP 631
            ..|:|..:      ||...|.|   :|:::......:..:...:||..|..        :||:..
  Fly   732 LLLQAQNESSKEVDQLCAQTET---IGVSEPATQQERERKLKNARAIIGNAIQPVIRRPTPFYGI 793

Human   632 AQSPGL-HGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAP--APFVIAPCDGPG 693
            ....|. .|||.|                        |:....:.||:.|.  :.|:     |..
  Fly   794 GNGFGNGMGGAVG------------------------ASGATVNNAPKRAQSGSSFM-----GYS 829

Human   694 AAPLPSTLLT----SGLPLLPPPLLQTGASPVASAAQLLDTHLHIG--TGPTALPA 743
            .|..|.|..|    ||....||.|:...|  :|.|.|.:...:..|  ..|...||
  Fly   830 GATSPGTAATSPPISGPQTAPPVLISPNA--LAVAKQTIQQRIFGGGLPSPNNQPA 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIK1	NP_775490.2	STKc_SIK	26..278	CDD:270973	116/252 (46%)
		UBA_SIK1	300..349	CDD:270591	10/48 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..377		6/38 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..477		5/35 (14%)
		RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305|PubMed:29211348	583..612		7/34 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	619..643		9/32 (28%)
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	116/254 (46%)