Protein Alignment SIK1 and sff

DIOPT Version :10

• Sequence 1: NP_775490.2
• Gene: SIK1 / 150094
• HGNCID: 11142
• Length: 783
• Species: Homo sapiens
• Sequence 2: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Alignment Length: 742
• Identity: 224/742 - (30%)
• Similarity: 325/742 - (43%)
• Gaps: 178/742 - (23%)

Human    24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIK 88
            ||.|.:|:|||||...:|||..|.|...:||||||::.:|..|.|.|:.||:.:|||::|||::.
  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLG 79

Human    89 LYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTE 153
            |..|.|.|..||::.|....||:||||...|.|:..||||.|.||:||:::||.|.|.|||||.|
  Fly    80 LSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPE 144

Human   154 NLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLV 218
            |||||...:||:||||..:...:|..|.|.||||.||.|||..|::|:|.:.|:||.||:||.|:
  Fly   145 NLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALL 209

Human   219 CGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRA--- 280
            .|:||||..||..|.::|..|.|.||.|:..||:||:|.|:.|:|.||:|:|:|.:|.|:.|
  Fly   210 VGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGGK 274

Human   281 -EPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGV--DRQRTVESLQNSSYNHFAAIYYLLL 342
             |..|..|.......|...:... .|...|..:.:||.  ::::.::.|.:||:|....||:|||
  Fly   275 GELELELPMMEVVQTHVIPTATA-VDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYFLLL 338

Human   343 ERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDC 407
            ||.:             |:|.....|    |:.|:.                       ::|:|.
  Fly   339 ERKR-------------RRPALEDDD----EIAQKS-----------------------RSELDA 363

Human   408 ELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRH 472
                         ||            .|...|||.
  Fly   364 -------------VD------------PPRKRLDTC----------------------------- 374

Human   473 TLAEVSTRLSPLTAPCI-VVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGAC--S 534
                   |::...||.. .:|..:..:|..  .:.:..::|::::....|.|..|..:..:.  |
  Fly   375 -------RINGTNAPSYGQISEGSPLTPRR--QAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHS 430

Human   535 PVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGF 599
            |.|..||...:|.     ||     .|:..|.|...|.|.|    |.|.:.........:||...
  Fly   431 PTRCNSPMSSAQQ-----QA-----NAISRPSSPAAGTRHS----TYGDRDRSGHHSSVSRTPSH 481

Human   600 LGLNKIKG---LARQ--VCQAPASRASRGGLSP-----FHAPAQSPGLHGGAAGSREGWSLLEEV 654
            .....|:|   :.|:  :.:..:.|..|||.||     ...|..|||  |.::||......:
  Fly   482 SSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGIPPGSPG--GNSSGSTSASPSV--- 541

Human   655 LEQQRLLQLQHHPAAA-----------PGCSQAPQPAPAPFVI--------APCDGPGAAPLPST 700
                      ||.|.:           |..:....|..:|.:.        :||:.|| ..|..|
  Fly   542 ----------HHRANSGPTIAISMFHDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPG-GQLWKT 595

Human   701 LLTS------GLPLLPPPLLQTGASPV 721
            .||:      |.|......:|..|..|
  Fly   596 RLTNIKNSFLGSPRFHRRKMQVSADEV 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIK1	NP_775490.2	STKc_SIK	26..278	CDD:270973	126/251 (50%)
		UBA_SIK1	300..349	CDD:270591	15/50 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..377		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..477		0/27 (0%)
		RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305|PubMed:29211348	583..612		5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	619..643		11/28 (39%)
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	127/252 (50%)
		UBA_BRSK	298..350	CDD:270525	17/64 (27%)