DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIK1 and Pask

DIOPT Version :10

Sequence 1:NP_775490.2 Gene:SIK1 / 150094 HGNCID:11142 Length:783 Species:Homo sapiens
Sequence 2:NP_611864.1 Gene:Pask / 37824 FlyBaseID:FBgn0034950 Length:985 Species:Drosophila melanogaster


Alignment Length:350 Identity:102/350 - (29%)
Similarity:165/350 - (47%) Gaps:46/350 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    26 FYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL------DSSNLEKIYREVQLMKLLNHP 84
            :|...|.:|:|.:..|.:|.....:..|..|.|.|.:|      .|.:.:::..|:.|::.|||.
  Fly   575 YYTSIRQIGRGAYGYVNMAFRNSDRLLVITKFILKEKLCSQFMVKSRDCKEVPIEIHLLQTLNHK 639

Human    85 HIIKLYQVMETKDMLY-IVTEFAKNG---EMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHI 145
            :|:.:..|.| .|:.| :|.|  |:|   :::.::.....:.|......|.|:..||.|.|:..|
  Fly   640 NIVSVLDVFE-NDLFYQLVME--KHGSGMDLWTFIERRPLMDEKLGSYIFRQVADAVNYLHEQKI 701

Human   146 VHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSL 210
            :|||:|.||:::|.|..|||.|||...|.:.|:..||:.|:..|.:|||..|..|.||:|:||:|
  Fly   702 LHRDIKDENIIIDQNFTIKLIDFGSATFMEEGKFFSTFYGTTEYCSPEVLAGNRYVGPELEIWAL 766

Human   211 GVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQH 275
            ||.||||:.    |:.|.:..  :..|:...:||..:|:....|:..||..||..|.|:.|:...
  Fly   767 GVTLYVLMF----FENPFIDV--EETLKAEIQIPKAVSEQLSRLLSSMLNKDPKYRCTMHQLITD 825

Human   276 RWMRAE------------PCLPGPACP--AFSAHSYTS-----------NLGDYDEQALGIMQTL 315
            .|:..|            ||....|.|  .||.:.|:|           :....:|.::|.....
  Fly   826 PWLTQEVNPSTFSFSWIVPCKAHEANPNLYFSGYLYSSTSVLSTISPQESFSHIEESSIGGSDDA 890

Human   316 GVDRQRTVESL--QNSSYNHFAAIY 338
            .:...||...|  ..:.:|....:|
  Fly   891 RLASHRTGHKLCVNEAKHNKMDTLY 915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIK1NP_775490.2 STKc_SIK 26..278 CDD:270973 85/261 (33%)
UBA_SIK1 300..349 CDD:270591 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..377
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..477
RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305|PubMed:29211348 583..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 619..643
PaskNP_611864.1 PAS 70..171 CDD:473914
PAS 182..350 CDD:441804
PAS 286..>325 CDD:238075
STKc_PASK 575..828 CDD:270906 85/261 (33%)
Blue background indicates that the domain is not in the aligned region.

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