DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIK1 and grp

DIOPT Version :10

Sequence 1:NP_775490.2 Gene:SIK1 / 150094 HGNCID:11142 Length:783 Species:Homo sapiens
Sequence 2:NP_477011.1 Gene:grp / 34993 FlyBaseID:FBgn0261278 Length:512 Species:Drosophila melanogaster


Alignment Length:408 Identity:115/408 - (28%)
Similarity:184/408 - (45%) Gaps:90/408 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    12 AGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIID-KTRLDSSNLEKIYREV 75
            ||.|....:....| :.:.:|||:|.:..|||..:|.|...||:|::| |...|::|  .:.:||
  Fly     8 AGTGPAATREFVEG-WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAAN--SVRKEV 69

Human    76 QLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYC 140
            .:.|:|...||::.:.......:.||..|:|..||:||.:..:..:.::||::.|.|:||.:.|.
  Fly    70 CIQKMLQDKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYL 134

Human   141 HDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYK-SGEP--LSTWCGSPPYAAPEVFEGKEYEG 202
            |...|.|||||.||||||.:.::|::|||....:: .|:.  |...||:.||.||||.: |.|..
  Fly   135 HQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQ-KAYHA 198

Human   203 PQLDIWSLGVVLYVLVCGSLPFDGPN-----------------------LPTLRQRVLEGRFRIP 244
            ...|:||.||:|..::.|.||:|.|:                       |.||            
  Fly   199 QPADLWSCGVILVTMLAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWSKLDTL------------ 251

Human   245 FFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMR------------------AEPCLPGPACPA 291
                  ..||:|::|...|..|:|:.:...|:|..                  .|.|.|......
  Fly   252 ------AISLLRKLLATSPGTRLTLEKTLDHKWCNMQFADNERSYDLVDSAAALEICSPKAKRQR 310

Human   292 FSAHSYTSN-LGD-----YDEQALGIMQT---------------LGVDRQRTVESLQNS-SYNHF 334
            ..:.::.|| |.|     |..|.:..|::               .|.|||...:..:.| |::..
  Fly   311 LQSSAHLSNGLDDSISRNYCSQPMPTMRSDDDFNVRLGSGRSKEDGGDRQTLAQEARLSYSFSQP 375

Human   335 AAIYYLLL-ERLKEYRNA 351
            |.:..||| .::.:.:||
  Fly   376 ALLDDLLLATQMNQTQNA 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIK1NP_775490.2 STKc_SIK 26..278 CDD:270973 88/278 (32%)
UBA_SIK1 300..349 CDD:270591 16/71 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..377
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..477
RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305|PubMed:29211348 583..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 619..643
grpNP_477011.1 STKc_Chk1 20..279 CDD:270971 89/280 (32%)
Blue background indicates that the domain is not in the aligned region.

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