DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIK1 and CG4629

DIOPT Version :10

Sequence 1:NP_775490.2 Gene:SIK1 / 150094 HGNCID:11142 Length:783 Species:Homo sapiens
Sequence 2:NP_608564.3 Gene:CG4629 / 33284 FlyBaseID:FBgn0031299 Length:570 Species:Drosophila melanogaster


Alignment Length:500 Identity:156/500 - (31%)
Similarity:243/500 - (48%) Gaps:91/500 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    23 RVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTR--LDSSNLEKIYREVQLMKLLNHPH 85
            |:|.|.....:|:|||:.||||.|::|:.:||||::|..|  ||:..|..:..|:..::.::||:
  Fly    62 RIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPN 126

Human    86 IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDL 150
            |::|::|:||...:|:|||:.:.||:::::|..|.|.|..|.....|:|.||::.|....||||:
  Fly   127 ILRLFEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDI 191

Human   151 KTENLLLDGNMDIKLADFGFGNFYKSG--EPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVV 213
            |.||:||.....:|||||||.....:|  :.|.|:||||||||||:|....|.|..:|:|:||::
  Fly   192 KAENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGIL 256

Human   214 LYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIA-------- 270
            ||.:|.|::||..|.:|.|:..:|:|.:.:|..:|..|..||:|:|:..||:|.||.        
  Fly   257 LYFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQFV 321

Human   271 ------------QIRQHR--------WMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGI---- 311
                        :|.||.        |:|::            :|....:....|..|..:    
  Fly   322 TCPKLSADLMQWEINQHTKPVKRSIFWVRSK------------SHRLRKSASLRDRYAEVVKKPA 374

Human   312 --MQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEV 374
              |.|...|.......||.....|  .:...:..:|||.::.:     .|::|..|......|:.
  Fly   375 ISMNTRQQDEMFVQNFLQPIEMGH--ELLVPVSSQLKEPQSTE-----QAKRPTRRYMFCGSLKK 432

Human   375 PQEGLSTDPFRPALLCPQPQTLVQSVLQAEM---------DCELQSSLQWPLFFPVDA---SCSG 427
            ....:.|:|.:      |.....||:..|::         ||        |||...||   ||  
  Fly   433 KVTPMETEPEK------QLANGGQSIGSAKINPWNVEVAEDC--------PLFKNYDAETGSC-- 481

Human   428 VFRPRPVSPSSLLDTAISEEARQ---GPGLEEEQ--DTQESLPSS 467
            |..|......|.|. |:..||||   ..||..|.  :.::|.|.|
  Fly   482 VMLPTNTEDLSQLG-ALEFEARQILAELGLTSEMLINARQSGPRS 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIK1NP_775490.2 STKc_SIK 26..278 CDD:270973 106/283 (37%)
UBA_SIK1 300..349 CDD:270591 11/54 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..377 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..477 7/23 (30%)
RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305|PubMed:29211348 583..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 619..643
CG4629NP_608564.3 STKc_NIM1 63..321 CDD:270977 104/257 (40%)
Blue background indicates that the domain is not in the aligned region.

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