DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTNND1 and VAC8

DIOPT Version :9

Sequence 1:	NP_001078927.1	Gene:	CTNND1 / 1500	HGNCID:	2515	Length:	968	Species:	Homo sapiens
Sequence 2:	NP_010903.3	Gene:	VAC8 / 856702	SGDID:	S000000739	Length:	578	Species:	Saccharomyces cerevisiae

Alignment Length:	662	Identity:	147/662 - (22%)
Similarity:	249/662 - (37%)	Gaps:	176/662 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   331 SDQYYWAPLAQHER-------GSLASLDSL--RKGGPPPPNWRQPELPEVIAML-GFRLDAVKSN 385
            ||:...:|:|.:||       |.|...|.|  ..|||         |..:..:: ...|:..:|.
Yeast    12 SDEASVSPIADNEREAVTLLLGYLEDKDQLDFYSGGP---------LKALTTLVYSDNLNLQRSA 67

Human   386 AAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNC 450
            |.|:.:    ..:|....|.:....|:|: ||.....::.:.||.||.|::.  :.:||:.|...
Yeast    68 ALAFAE----ITEKYVRQVSREVLEPILI-LLQSQDPQIQVAACAALGNLAV--NNENKLLIVEM 125

Human   451 DGVPALVRLLRKARDMDLTEV---ITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREP 512
            .|:..|:..:..    |..||   ..|.:.||::.|..|.:|.       |...:||.:
Yeast   126 GGLEPLINQMMG----DNVEVQCNAVGCITNLATRDDNKHKIA-------TSGALIPLT------ 173

Human   513 NEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVE 577
             :..|.:||.   |..|..|.|.|::  .||..||.....|.|..|:.::.:      :|..:..
Yeast   174 -KLAKSKHIR---VQRNATGALLNMT--HSEENRKELVNAGAVPVLVSLLSS------TDPDVQY 226

Human   578 NCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGK----KPIED 638
            .|...|.|::      :.:|.|.:.|      .|.|...|...:.  .|...||.|    ..:.:
Yeast   227 YCTTALSNIA------VDEANRKKLA------QTEPRLVSKLVSL--MDSPSSRVKCQATLALRN 277

Human   639 PANDTVDFPKRTSPARGYELLFQPEVVRI-----YISLLKESKTPAILEASAGAIQNLCAGRWTY 698
            .|:||           .|:|    |:||.     .:.|::....|.:| ||...|:|:.......
Yeast   278 LASDT-----------SYQL----EIVRAGGLPHLVKLIQSDSIPLVL-ASVACIRNISIHPLNE 326

Human   699 GRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLA--VDARNKELIGKHAIPNLVKNLPG 761
            |              .|.|             :|.|:.|.  :|.::.|.|..||:..| :||..
Yeast   327 G--------------LIVD-------------AGFLKPLVRLLDYKDSEEIQCHAVSTL-RNLAA 363

Human   762 GQQNSSWNFSE------------DTVISILNTINE--VIAENLEAAK-KLRETQGIEKLVLINKS 811
            ..:.:...|.|            |:.:|:.:.|:.  .|....:.:| .|.|...::.|:.:..|
Yeast   364 SSEKNRKEFFESGAVEKCKELALDSPVSVQSEISACFAILALADVSKLDLLEANILDALIPMTFS 428

Human   812 GNRSEKEVRAAAL--VLQTIWGYKELRKPLEK--EG-------WKKSDFQVNLNNA--SRSQSSH 863
            .|:......||||  :...:..|.::.:..::  ||       :.|||:....:.|  :..|...
Yeast   429 QNQEVSGNAAAALANLCSRVNNYTKIIEAWDRPNEGIRGFLIRFLKSDYATFEHIALWTILQLLE 493

Human   864 SYDDSTLPLIDRNQKSD---------------KKPDREEIQMSNMGSNT--KSLDNNYSTPNERG 911
            |::|....|:    |:|               ::..|..|.:.|.|||.  .|.|||.:..:...
Yeast   494 SHNDKVEDLV----KNDDDIINGVRKMADVTFERLQRSGIDVKNPGSNNNPSSNDNNSNNNDTGS 554

Human   912 DHNRTLDRSGDL 923
            :|....|.|.:|
Yeast   555 EHQPVEDASLEL 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTNND1	NP_001078927.1	Necessary and sufficient for interaction with CCDC85B. /evidence=ECO:0000269\|PubMed:25009281	1..357		10/34 (29%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	299..306
		ARM 1	358..395		6/37 (16%)
		ARM	363..481	CDD:237987	27/121 (22%)
		armadillo repeat	368..393	CDD:293788	5/25 (20%)
		ARM 2	398..437		11/38 (29%)
		armadillo repeat	401..437	CDD:293788	10/35 (29%)
		ARM 3	441..475		8/36 (22%)
		armadillo repeat	444..479	CDD:293788	8/37 (22%)
		ARM 4	476..516		8/39 (21%)
		armadillo repeat	486..537	CDD:293788	12/50 (24%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	521..528		2/6 (33%)
		ARM	524..>588	CDD:237987	16/63 (25%)
		ARM 5	534..573		9/38 (24%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	568..575		1/6 (17%)
		ARM 6	583..624		8/40 (20%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	622..629		1/6 (17%)
		ARM 7	653..693		12/44 (27%)
		armadillo repeat	656..693	CDD:293788	12/41 (29%)
		ARM	657..759	CDD:237987	23/108 (21%)
		ARM 8	700..739		5/40 (13%)
		armadillo repeat	703..737	CDD:293788	4/33 (12%)
		ARM 9	740..780		12/51 (24%)
		armadillo repeat	744..787	CDD:293788	12/56 (21%)
		ARM 10	781..826		12/49 (24%)
		armadillo repeat	793..829	CDD:293788	10/38 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..944		21/88 (24%)
VAC8	NP_010903.3	SRP1	42..>358	CDD:227396	91/417 (22%)
		armadillo repeat	119..155	CDD:293788	10/39 (26%)
		armadillo repeat	160..194	CDD:293788	12/50 (24%)
		armadillo repeat	204..235	CDD:293788	6/36 (17%)
		armadillo repeat	242..280	CDD:293788	9/45 (20%)
		armadillo repeat	286..319	CDD:293788	10/37 (27%)
		armadillo repeat	326..361	CDD:293788	12/62 (19%)
		armadillo repeat	369..402	CDD:293788	5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910