DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTNND1 and ctnnd1

DIOPT Version :9

Sequence 1:	NP_001078927.1	Gene:	CTNND1 / 1500	HGNCID:	2515	Length:	968	Species:	Homo sapiens
Sequence 2:	NP_001119545.1	Gene:	ctnnd1 / 100101665	XenbaseID:	XB-GENE-919827	Length:	864	Species:	Xenopus tropicalis

Alignment Length:	983	Identity:	485/983 - (49%)
Similarity:	620/983 - (63%)	Gaps:	156/983 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQ 65
            ||:.|.||.|||||||:.||||||.|:|||||||||::|||:||.|:||:  |.:.||:.||..|
Frog     1 MDEPESESPASILASVRAQEAQFELLSRALEEERRHITAQLDRVWVTPQE--PPLTNGSHTRCQQ 63

Human    66 NGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSD 130
            :|                        |..||::...........|.|..:|..   |..|...:|
Frog    64 DG------------------------SPFLYTSTRMEAHSVHADERYVIDDDS---SYKSCTLND 101

Human   131 DGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVG 195
            :  ||..|..|:.:|                           .|.|||.|.:|:...|| |.|
Frog   102 E--TRCNEIPVQTIV---------------------------GYSQTLDRPYREPAGGG-GTY-- 134

Human   196 QAGTATLPRNFHYPPDGYSRHY----EDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDV 256
                .|:|||:|:...|.....    :..:||    |.||||.   .:||| |::.||.|.
Frog   135 ----TTVPRNYHFRGPGVDSTMPVISQSPHPG----YSSLSRP---NQRYR-SIDPYRGPG---- 183

Human   257 YGPQPQVR---VGGSSVDL--HRFH--PEPYGLEDDQRSMG--YDDLDYGMMSDYGTARRTGTPS 312
            ||||||||   :|||..||  .|.:  .:.||||||:||:|  .|..||..     |.||.....
Frog   184 YGPQPQVRGGGLGGSQSDLLSGRVYGSEDAYGLEDDRRSLGGYIDGPDYAT-----TGRRGANGG 243

Human   313 DPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPP----PN---WRQPELPE 370
            |||||||||||.:     ||::...|.:    |||:||      ||.|    |.   |:||||||
Frog   244 DPRRRLRSYEDPL-----SDRFGSVPTS----GSLSSL------GPAPLTLAPTSGPWKQPELPE 293

Human   371 VIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNI 435
            |:|||.:.||||:.|||||||||.|||:.||.:|.:|:|||.|:.||:.|:..|.|.|||||||:
Frog   294 VLAMLSYTLDAVRLNAAAYLQHLSYRNEDVKKEVCRLRGIPPLISLLEDPRAPVRLAACGALKNL 358

Human   436 SFGRDQDNKIAIKNCDGVPALVRLLRKARD----MDLTEVITGTLWNLSSHDSIKMEIVDHALHA 496
            |:|..::||:|:|||||||||.|||.:..:    .:|.|.:|||||||||.||||||:||.||:.
Frog   359 SYGPARENKMAVKNCDGVPALARLLHRRGEGKEGRELAECVTGTLWNLSSLDSIKMELVDQALYT 423

Human   497 LTDEVIIPHSGWER----EPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDA 557
            ||.|:::|||||::    :...:.||||:|||..|.||.|||||:||||||||||:|||:|||::
Frog   424 LTQEILVPHSGWQQDGVMQVVVEGKPRHVEWEPALVNTTGCLRNISSERSEARRKMRECEGLVES 488

Human   558 LIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAK 622
            ::.|:::|:.....|||||||.|||||||||.:|||||.||:|.|..||.:..|  ...||||.:
Frog   489 VVHILRSEVSHGQVDSKLVENVVCLLRNLSYHIHREIPHAEKYMENPPNASAET--QNPSCFGVR 551

Human   623 KGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGA 687
            :||      |||..|:...||:||||||.||:||:||||||:||:||||:|.|.|||:|||||||
Frog   552 RGK------GKKASEESVVDTIDFPKRTMPAQGYDLLFQPEIVRLYISLVKLSHTPAVLEASAGA 610

Human   688 IQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAI 752
            |||||||.|.|||.||:|:||||.||::||.||:|.||||:|..||||||..|:||:|||||||:
Frog   611 IQNLCAGNWVYGRCIRAAVRQEKGLSSLADHLTHESERVVRAICGALRNLCGDSRNRELIGKHAL 675

Human   753 PNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEK 817
            .:||..|......|| ..||||.:.:::||:|||:.||||||:|||:||||:||||||.|.||:|
Frog   676 NSLVARLSSSSAQSS-ALSEDTNVGVISTIHEVISGNLEAAKRLRESQGIERLVLINKGGGRSDK 739

Human   818 EVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKK 882
            |:|||...|||||||||||:||||:|||::||||:....||.|   .||||||||||||.|::||
Frog   740 EIRAAGFCLQTIWGYKELRRPLEKDGWKRNDFQVSTAVTSRVQ---VYDDSTLPLIDRNLKNEKK 801

Human   883 PDREEIQMSNMGSNTKSLDNNYSTPNERGD-HNRTLDRSGDLGDMEPLKGTTPLMQDE-----GQ 941
            .:..:|.:::.  .|....:|       || .||..:||.:|.:::|||    :||:.     |.
Frog   802 SENTDIPLNDF--RTDPFAHN-------GDSSNRLPNRSEELSELDPLK----VMQERSVSAGGS 853

Human   942 ESLEEELD 949
            .||.:..|
Frog   854 LSLGDAED 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTNND1	NP_001078927.1	Necessary and sufficient for interaction with CCDC85B. /evidence=ECO:0000269\|PubMed:25009281	1..357		135/368 (37%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	299..306		1/6 (17%)
		ARM 1	358..395		27/43 (63%)
		ARM	363..481	CDD:237987	73/121 (60%)
		armadillo repeat	368..393	CDD:293788	18/24 (75%)
		ARM 2	398..437		20/38 (53%)
		armadillo repeat	401..437	CDD:293788	19/35 (54%)
		ARM 3	441..475		18/37 (49%)
		armadillo repeat	444..479	CDD:293788	21/38 (55%)
		ARM 4	476..516		24/43 (56%)
		armadillo repeat	486..537	CDD:293788	29/54 (54%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	521..528		3/6 (50%)
		ARM	524..>588	CDD:237987	41/63 (65%)
		ARM 5	534..573		21/38 (55%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	568..575		2/6 (33%)
		ARM 6	583..624		22/40 (55%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:P30999	622..629		2/6 (33%)
		ARM 7	653..693		31/39 (79%)
		armadillo repeat	656..693	CDD:293788	29/36 (81%)
		ARM	657..759	CDD:237987	72/101 (71%)
		ARM 8	700..739		26/38 (68%)
		armadillo repeat	703..737	CDD:293788	22/33 (67%)
		ARM 9	740..780		19/39 (49%)
		armadillo repeat	744..787	CDD:293788	20/42 (48%)
		ARM 10	781..826		32/44 (73%)
		armadillo repeat	793..829	CDD:293788	25/35 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..944		34/94 (36%)
ctnnd1	NP_001119545.1	ARM	286..408	CDD:237987	73/121 (60%)
		armadillo repeat	291..316	CDD:293788	18/24 (75%)
		armadillo repeat	324..360	CDD:293788	19/35 (54%)
		armadillo repeat	367..406	CDD:293788	21/38 (55%)
		armadillo repeat	413..468	CDD:293788	29/54 (54%)
		ARM	455..>520	CDD:237987	42/64 (66%)
		ARM	580..>674	CDD:237987	68/93 (73%)
		armadillo repeat	582..616	CDD:293788	27/33 (82%)
		armadillo repeat	626..660	CDD:293788	22/33 (67%)
		armadillo repeat	715..751	CDD:293788	25/35 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	283	1.000	Domainoid score	I10074
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1017
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	1	1.000	-	-		FOG0004926
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010