Protein Alignment ADRA2A and Oamb

DIOPT Version :9

• Sequence 1: NP_000672.3
• Gene: ADRA2A / 150
• HGNCID: 281
• Length: 465
• Species: Homo sapiens
• Sequence 2: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 582
• Identity: 160/582 - (27%)
• Similarity: 233/582 - (40%)
• Gaps: 187/582 - (32%)

Human    51 LVCLAGL--LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY 113
            |:.||.|  :.:|.:.||.|||.|||.|..|::..|.|:|:||.||:||...|:|||...||...
  Fly    21 LISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKV 85

Human   114 WYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAV 178
            |.||..||.|:||:||..||:||::|||||||||.::|:.:.|....:.::.|::|..:||:|..
  Fly    86 WIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFF 150

Human   179 ISFPPLI-------------------------------------SIEKK------------GGGG 194
            |.||||:                                     ||:.:            |.|.
  Fly   151 ICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGN 215

Human   195 GPQPAEP---------------------------------------------------------- 201
            ...|.:|
  Fly   216 AYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTIS 280

Human   202 -----RCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPG-G 260
                 :||:.:.:.||:.|.:|||:.|..:|:..|.|||:.|.|.||.  ..:|........| |
  Fly   281 GSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRA--INQGFKTTKGSKGIG 343

Human   261 TERRPNGLGPERSAGPGGAEAEPLPTQLNGAP-------GEPAP--------------------- 297
            :......|......|.|..:.:.:.:  ||:.       |.|:|
  Fly   344 SRFEEQRLTLRIHRGRGSNQQDSMHS--NGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISV 406

Human   298 AGPRDTDALDLEESSSSDHAERPPGPRR---PERGPRGK--------------GKARASQVKPGD 345
            :.|...:..:|.......|..|..|...   ...|..|:              |.|.:..::.|.
  Fly   407 SYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGK 471

Human   346 SLP---RRGPGATGIGTPAAGPGEERVGAAKASRWRGRQN---REKRFTF------VLAVVIGVF 398
            .||   ||....    :.|.|.|..|    .|::..||:|   :.|||..      .||:::|:|
  Fly   472 GLPELARRQSNT----SEAGGSGHSR----PANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMF 528

Human   399 VVCWFPFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCR 458
            :.||.|||..|.:... |.  |...||...||.|||||::||:||.:|:.|||.|||:|:||
  Fly   529 IFCWCPFFTMYIIRPF-CQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICR 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADRA2A	NP_000672.3	7tmA_alpha2A_AR	49..452	CDD:320445	154/574 (27%)
		TM helix 1	51..75	CDD:320445	12/25 (48%)
		TM helix 2	84..106	CDD:320445	12/21 (57%)
		TM helix 3	122..144	CDD:320445	13/21 (62%)
		TM helix 4	167..183	CDD:320445	6/15 (40%)
		TM helix 5	209..232	CDD:320445	8/22 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..368		30/174 (17%)
		PHA03307	244..>389	CDD:223039	36/196 (18%)
		TM helix 6	388..410	CDD:320445	9/27 (33%)
		TM helix 7	420..445	CDD:320445	13/24 (54%)
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	57/124 (46%)
		7tm_1	37..>181	CDD:278431	60/143 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870