DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTNNB1 and VAC8

DIOPT Version :9

Sequence 1:	NP_001091679.1	Gene:	CTNNB1 / 1499	HGNCID:	2514	Length:	781	Species:	Homo sapiens
Sequence 2:	NP_010903.3	Gene:	VAC8 / 856702	SGDID:	S000000739	Length:	578	Species:	Saccharomyces cerevisiae

Alignment Length:	641	Identity:	132/641 - (20%)
Similarity:	248/641 - (38%)	Gaps:	159/641 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   115 DAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAE----LATRAIPELTKLLNDEDQVVVNKAAVMV 175
            |::...:|..:|:..   :.||..|:.|.:|.:    .:...:..||.|:..::..:...||:..
Yeast    10 DSSDEASVSPIADNE---REAVTLLLGYLEDKDQLDFYSGGPLKALTTLVYSDNLNLQRSAALAF 71

Human   176 HQLSKK---EASRHAIMRSPQMVSAIVRTMQNTN-DVETARCTAGTLHNLSHHREGLLAIFKSGG 236
            .::::|   :.||       :::..|:..:|:.: .::.|.|.|  |.||:.:.|..|.|.:.||
Yeast    72 AEITEKYVRQVSR-------EVLEPILILLQSQDPQIQVAACAA--LGNLAVNNENKLLIVEMGG 127

Human   237 I-PALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC 300
            : |.:.:|:|..|: |...|:..:.||....:. |..:..:|.|..:..|
Yeast   128 LEPLINQMMGDNVE-VQCNAVGCITNLATRDDN-KHKIATSGALIPLTKL--------------- 175

Human   301 LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQA 365
                    .:||.|.:......||:|:  |::.|                  |:..:|.||.:..
Yeast   176 --------AKSKHIRVQRNATGALLNM--THSEE------------------NRKELVNAGAVPV 212

Human   366 LG--LHLTDPSQRLVQNCLWTLRNLS-DAATKQEGME---GLLGTLVQLLGSDDINVVTCAAGIL 424
            |.  |..|||..:..  |...|.|:: |.|.:::..:   .|:..||.|:.|....|...|...|
Yeast   213 LVSLLSSTDPDVQYY--CTTALSNIAVDEANRKKLAQTEPRLVSKLVSLMDSPSSRVKCQATLAL 275

Human   425 SNLTCN-NYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLH 488
            .||..: :|:.:               ::|||
Yeast   276 RNLASDTSYQLE---------------IVRAG--------------------------------- 292

Human   489 YGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL-------VRAHQD 546
             |||.:|||:...| .||:.|:|..|||:::.|.|...:.:.|.:..||:||       ::.|..
Yeast   293 -GLPHLVKLIQSDS-IPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRLLDYKDSEEIQCHAV 355

Human   547 TQRR---TSMGGTQQQFVEGVRMEEIVE-----------GCTGALHILARDVHNRIVIRGLNTIP 597
            :..|   .|....:::|.|...:|:..|           ..:....|||....:::.:...|.:.
Yeast   356 STLRNLAASSEKNRKEFFESGAVEKCKELALDSPVSVQSEISACFAILALADVSKLDLLEANILD 420

Human   598 LFVQLLYSPIENIQRVAAGVLCEL-AQDKEAAEAIEA-----EGATAPLTELL---HSRNEGVAT 653
            ..:.:.:|..:.:...||..|..| ::.....:.|||     ||....|...|   ::..|.:|.
Yeast   421 ALIPMTFSQNQEVSGNAAAALANLCSRVNNYTKIIEAWDRPNEGIRGFLIRFLKSDYATFEHIAL 485

Human   654 YAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDI---GAQGEP 706
            :....|.....||.:|..|. ..::.:.:.:...:.:......|:|:   |:...|
Yeast   486 WTILQLLESHNDKVEDLVKN-DDDIINGVRKMADVTFERLQRSGIDVKNPGSNNNP 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTNNB1	NP_001091679.1	Interaction with VCL. /evidence=ECO:0000250	2..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..57
		SRP1	142..>431	CDD:227396	67/304 (22%)
		ARM 1	151..191		8/42 (19%)
		armadillo repeat	153..178	CDD:293788	5/24 (21%)
		Interaction with BCL9. /evidence=ECO:0000269\|PubMed:17052462	156..178		5/21 (24%)
		armadillo repeat	188..221	CDD:293788	6/33 (18%)
		ARM 2	193..234		11/41 (27%)
		armadillo repeat	230..262	CDD:293788	9/32 (28%)
		ARM	230..262	CDD:214547	9/32 (28%)
		ARM 3	235..276		11/41 (27%)
		armadillo repeat	270..306	CDD:293788	4/35 (11%)
		ARM 4	277..318		6/40 (15%)
		armadillo repeat	312..347	CDD:293788	7/34 (21%)
		ARM 5	319..360		7/40 (18%)
		ARM	350..390	CDD:214547	12/42 (29%)
		armadillo repeat	354..389	CDD:293788	11/36 (31%)
		ARM 6	361..389		9/29 (31%)
		ARM 7	400..441		11/41 (27%)
		armadillo repeat	402..427	CDD:293788	7/24 (29%)
		Arm	431..473	CDD:395413	4/41 (10%)
		armadillo repeat	435..473	CDD:293788	3/37 (8%)
		ARM 8	442..484		3/41 (7%)
		armadillo repeat	482..517	CDD:293788	13/34 (38%)
		ARM 9	489..530		16/40 (40%)
		armadillo repeat	524..582	CDD:293788	14/78 (18%)
		ARM 10	531..571		11/49 (22%)
		Arm	583..622	CDD:395413	6/39 (15%)
		armadillo repeat	587..621	CDD:293788	5/33 (15%)
		ARM 11	594..636		10/47 (21%)
		armadillo repeat	629..662	CDD:293788	10/40 (25%)
		ARM 12	637..666		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..781		1/2 (50%)
		Interaction with SCRIB. /evidence=ECO:0000250	772..781
VAC8	NP_010903.3	SRP1	42..>358	CDD:227396	91/421 (22%)
		armadillo repeat	119..155	CDD:293788	12/36 (33%)
		armadillo repeat	160..194	CDD:293788	9/56 (16%)
		armadillo repeat	204..235	CDD:293788	10/32 (31%)
		armadillo repeat	242..280	CDD:293788	10/37 (27%)
		armadillo repeat	286..319	CDD:293788	16/82 (20%)
		armadillo repeat	326..361	CDD:293788	7/34 (21%)
		armadillo repeat	369..402	CDD:293788	4/32 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2582
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.890