Protein Alignment CTNNB1 and NRK1

DIOPT Version :10

• Sequence 1: NP_001895.1
• Gene: CTNNB1 / 1499
• HGNCID: 2514
• Length: 781
• Species: Homo sapiens
• Sequence 2: NP_014270.1
• Gene: NRK1 / 855594
• SGDID: S000005073
• Length: 240
• Species: Saccharomyces cerevisiae
• Alignment Length: 213
• Identity: 37/213 - (17%)
• Similarity: 67/213 - (31%)
• Gaps: 54/213 - (25%)

Human     6 DLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGK------GNPEEEDVDTS---- 60
            |..:.|..:..|.|..:.:|.....||..:. |........:||      .|...:|..|.
Yeast    40 DFYKHDNEVPVDAKYNIQNWDSPEALDFKLF-GKELDVIKQTGKIATKLIHNNNVDDPFTKFHID 103

Human    61 -QVLYEWEQ---------------------------GFSQSFTQEQVADIDGQYAMTRAQRVRAA 97
             ||   |::                           |.|:.|..:.:  :...|.:.:.:|....
Yeast   104 RQV---WDELKAKYDSINDDKYEVVIVDGFMIFNNTGISKKFDLKIL--VRAPYEVLKKRRASRK 163

Human    98 MFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLND 162
            .: :|||.....|...||        .....|....||.: .:|...:..|..|....:.:.:||
Yeast   164 GY-QTLDSFWVDPPYYFD--------EFVYESYRANHAQL-FVNGDVEGLLDPRKSKNIKEFIND 218

Human   163 EDQVVVNKAAVMVHQLSK 180
            :|..:....:.:..::.|
Yeast   219 DDTPIAKPLSWVCQEILK 236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTNNB1	NP_001895.1	Interaction with VCL. /evidence=ECO:0000250	2..23		4/16 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..57		4/28 (14%)
		CTNNAbd_CTNNB1	78..151	CDD:439241	13/72 (18%)
		SRP1	142..>431	CDD:227396	6/39 (15%)
		ARM 1	151..191		5/30 (17%)
		armadillo repeat	153..178	CDD:293788	3/24 (13%)
		Interaction with BCL9. /evidence=ECO:0000269|PubMed:17052462	156..178		3/21 (14%)
		armadillo repeat	188..221	CDD:293788
		ARM 2	193..234
		armadillo repeat	230..262	CDD:293788
		ARM	230..262	CDD:214547
		ARM 3	235..276
		armadillo repeat	270..306	CDD:293788
		ARM 4	277..318
		armadillo repeat	312..347	CDD:293788
		ARM 5	319..360
		ARM	350..390	CDD:214547
		armadillo repeat	354..389	CDD:293788
		ARM 6	361..389
		ARM 7	400..441
		armadillo repeat	402..427	CDD:293788
		Arm	431..473	CDD:425727
		armadillo repeat	435..473	CDD:293788
		ARM 8	442..484
		armadillo repeat	482..517	CDD:293788
		ARM 9	489..530
		armadillo repeat	524..582	CDD:293788
		ARM 10	531..571
		Arm	583..622	CDD:425727
		armadillo repeat	587..621	CDD:293788
		ARM 11	594..636
		armadillo repeat	629..662	CDD:293788
		ARM 12	637..666
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	705..781
		Interaction with SCRIB. /evidence=ECO:0000250	772..781
NRK1	NP_014270.1	NRK1	8..198	CDD:238982	30/173 (17%)