Protein Alignment CTNNB1 and DAS2

DIOPT Version :10

• Sequence 1: NP_001895.1
• Gene: CTNNB1 / 1499
• HGNCID: 2514
• Length: 781
• Species: Homo sapiens
• Sequence 2: NP_010303.3
• Gene: DAS2 / 851583
• SGDID: S000002427
• Length: 232
• Species: Saccharomyces cerevisiae
• Alignment Length: 77
• Identity: 22/77 - (28%)
• Similarity: 32/77 - (41%)
• Gaps: 10/77 - (12%)

Human   626 EAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAW 690
            |..:.||.....|.|  ::.|.||.:   ..|||........:|.|.::....|::..|  |..|
Yeast   157 EMQQYIEPTRTFADL--IIPSTNENL---GRAVLVDGIVKAIEDTKSQIEGNNTNNKIR--PRLW 214

Human   691 N---ETADLGLD 699
            :   ||.||..|
Yeast   215 DFEAETMDLEKD 226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTNNB1	NP_001895.1	Interaction with VCL. /evidence=ECO:0000250	2..23
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..57
		CTNNAbd_CTNNB1	78..151	CDD:439241
		SRP1	142..>431	CDD:227396
		ARM 1	151..191
		armadillo repeat	153..178	CDD:293788
		Interaction with BCL9. /evidence=ECO:0000269|PubMed:17052462	156..178
		armadillo repeat	188..221	CDD:293788
		ARM 2	193..234
		armadillo repeat	230..262	CDD:293788
		ARM	230..262	CDD:214547
		ARM 3	235..276
		armadillo repeat	270..306	CDD:293788
		ARM 4	277..318
		armadillo repeat	312..347	CDD:293788
		ARM 5	319..360
		ARM	350..390	CDD:214547
		armadillo repeat	354..389	CDD:293788
		ARM 6	361..389
		ARM 7	400..441
		armadillo repeat	402..427	CDD:293788
		Arm	431..473	CDD:425727
		armadillo repeat	435..473	CDD:293788
		ARM 8	442..484
		armadillo repeat	482..517	CDD:293788
		ARM 9	489..530
		armadillo repeat	524..582	CDD:293788
		ARM 10	531..571
		Arm	583..622	CDD:425727
		armadillo repeat	587..621	CDD:293788
		ARM 11	594..636		3/9 (33%)
		armadillo repeat	629..662	CDD:293788	10/32 (31%)
		ARM 12	637..666		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	705..781
		Interaction with SCRIB. /evidence=ECO:0000250	772..781
DAS2	NP_010303.3	NK	12..196	CDD:450170	11/43 (26%)