Protein Alignment CTNNB1 and ctnnb1

DIOPT Version :10

• Sequence 1: NP_001895.1
• Gene: CTNNB1 / 1499
• HGNCID: 2514
• Length: 781
• Species: Homo sapiens
• Sequence 2: NP_001016958.1
• Gene: ctnnb1 / 549712
• XenbaseID: XB-GENE-487200
• Length: 781
• Species: Xenopus tropicalis
• Alignment Length: 781
• Identity: 765/781 - (97%)
• Similarity: 774/781 - (99%)
• Gaps: 0/781 - (0%)

Human     1 MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYE 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||:|||||
 Frog     1 MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEDEDVDTNQVLYE 65

Human    66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQ 130
            |||||||||||:||||||||||||||||||||||||||||||||||||||:||||||||||||||
 Frog    66 WEQGFSQSFTQDQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDSAHPTNVQRLAEPSQ 130

Human   131 MLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   131 MLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMV 195

Human   196 SAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLH 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   196 SAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLH 260

Human   261 NLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALV 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   261 NLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALV 325

Human   326 NIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSD 390
            ||||||:||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||
 Frog   326 NIMRTYSYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDSSQRLVQNCLWTLRNLSD 390

Human   391 AATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAG 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   391 AATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAG 455

Human   456 DREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALC 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   456 DREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALC 520

Human   521 PANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVH 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   521 PANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVH 585

Human   586 NRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEG 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   586 NRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEG 650

Human   651 VATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPS 715
            ||||||||||||||||||||||||||||||||||||||.|||.||||||||||||||||||||||
 Frog   651 VATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMPWNEAADLGLDIGAQGEPLGYRQDDPS 715

Human   716 YRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD 780
            |||||:.||||||:|||.||:|:|.||||||||||||||||.|||||||||||||||||||||||
 Frog   716 YRSFHAPGYGQDAMGMDSMMDHDMAGHHPGADYPVDGLPDLSHAQDLMDGLPPGDSNQLAWFDTD 780

Human   781 L 781
            |
 Frog   781 L 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTNNB1	NP_001895.1	Interaction with VCL. /evidence=ECO:0000250	2..23		20/20 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..57		21/22 (95%)
		CTNNAbd_CTNNB1	78..151	CDD:439241	71/72 (99%)
		SRP1	142..>431	CDD:227396	286/288 (99%)
		ARM 1	151..191		39/39 (100%)
		armadillo repeat	153..178	CDD:293788	24/24 (100%)
		Interaction with BCL9. /evidence=ECO:0000269|PubMed:17052462	156..178		21/21 (100%)
		armadillo repeat	188..221	CDD:293788	32/32 (100%)
		ARM 2	193..234		40/40 (100%)
		armadillo repeat	230..262	CDD:293788	31/31 (100%)
		ARM	230..262	CDD:214547	31/31 (100%)
		ARM 3	235..276		40/40 (100%)
		armadillo repeat	270..306	CDD:293788	35/35 (100%)
		ARM 4	277..318		40/40 (100%)
		armadillo repeat	312..347	CDD:293788	33/34 (97%)
		ARM 5	319..360		39/40 (98%)
		ARM	350..390	CDD:214547	38/39 (97%)
		armadillo repeat	354..389	CDD:293788	33/34 (97%)
		ARM 6	361..389		26/27 (96%)
		ARM 7	400..441		40/40 (100%)
		armadillo repeat	402..427	CDD:293788	24/24 (100%)
		Arm	431..473	CDD:425727	41/41 (100%)
		armadillo repeat	435..473	CDD:293788	37/37 (100%)
		ARM 8	442..484		41/41 (100%)
		armadillo repeat	482..517	CDD:293788	34/34 (100%)
		ARM 9	489..530		40/40 (100%)
		armadillo repeat	524..582	CDD:293788	57/57 (100%)
		ARM 10	531..571		39/39 (100%)
		Arm	583..622	CDD:425727	38/38 (100%)
		armadillo repeat	587..621	CDD:293788	33/33 (100%)
		ARM 11	594..636		41/41 (100%)
		armadillo repeat	629..662	CDD:293788	32/32 (100%)
		ARM 12	637..666		28/28 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	705..781		67/75 (89%)
		Interaction with SCRIB. /evidence=ECO:0000250	772..781		8/8 (100%)
ctnnb1	NP_001016958.1	CTNNAbd_CTNNB1	78..151	CDD:439241	71/72 (99%)
		armadillo repeat	153..178	CDD:293788	24/24 (100%)
		armadillo repeat	188..221	CDD:293788	32/32 (100%)
		PLN03200	216..>661	CDD:215629	442/444 (100%)
		armadillo repeat	230..262	CDD:293788	31/31 (100%)
		ARM	230..262	CDD:214547	31/31 (100%)
		armadillo repeat	270..306	CDD:293788	35/35 (100%)
		armadillo repeat	312..347	CDD:293788	33/34 (97%)
		ARM	350..390	CDD:214547	38/39 (97%)
		armadillo repeat	354..389	CDD:293788	33/34 (97%)
		armadillo repeat	402..427	CDD:293788	24/24 (100%)
		armadillo repeat	435..473	CDD:293788	37/37 (100%)
		armadillo repeat	482..517	CDD:293788	34/34 (100%)
		armadillo repeat	524..582	CDD:293788	57/57 (100%)
		Arm	583..622	CDD:425727	38/38 (100%)
		armadillo repeat	587..621	CDD:293788	33/33 (100%)
		armadillo repeat	629..662	CDD:293788	32/32 (100%)