Protein Alignment CTNNB1 and l(2)k01209

DIOPT Version :10

• Sequence 1: NP_001895.1
• Gene: CTNNB1 / 1499
• HGNCID: 2514
• Length: 781
• Species: Homo sapiens
• Sequence 2: NP_725672.2
• Gene: l(2)k01209 / 36953
• FlyBaseID: FBgn0022029
• Length: 626
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 104/501 - (20%)
• Similarity: 169/501 - (33%)
• Gaps: 156/501 - (31%)

Human   284 ALLNKTNVKF-----LAITTDCLQILAYGNQ-ESKLIILASGGPQALVNIM---RTYTYEKLL-W 338
            ||:|:.|...     :.:..|.|..|..|.: |..:....:.|.::....|   ....:|.:| :
  Fly   235 ALINEYNFDHPDAFDIELLLDVLTKLKEGRKVEVPVYNFVTHGRESQTKTMYGANVIIFEGILTF 299

Human   339 TTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLG 403
            .:..|||:|.:     ...|:           |||..||.:.   ..|::|     |.|.: |.|
  Fly   300 HSPEVLKLLDM-----KIFVD-----------TDPDIRLARR---LRRDIS-----QRGRD-LKG 339

Human   404 TLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICAL 468
            .|.|.|     |:|..:       .||.....|....:        .|.|.||    .:.||
  Fly   340 VLKQYL-----NMVKPS-------YCNYIAPTMAHADI--------IVPRGGD----NKVAI--- 377

Human   469 RHLTSRHQEAEMAQNAVRLHYGL---------PVVVKLLHPPSHWPLIKATVGLIRNLALCPANH 524
             ||..:|...::.....:|...|         |..:.||||.   |.||.....||    |   .
  Fly   378 -HLIVQHVHTQLQLRGFKLRETLANSYKDQPMPHSLHLLHPT---PQIKGLHTFIR----C---R 431

Human   525 APLREQGAI--PRLVQLLVRAHQD--TQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVH 585
            ...|::...  .||::|::.....  ..::|::...|....||.|||             :|.:.
  Fly   432 NTSRDEFIFYSKRLIRLVIEYALSLFPFKKTTVETPQGVLYEGKRME-------------SRKIC 483

Human   586 NRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSR--- 647
            ...::|...|:...|                  |::.:|....:.:..........||.:.|
  Fly   484 GVSILRAGETMEQAV------------------CDVCKDIRIGKILIQTNLKTGEPELYYLRLPK 530

Human   648 ----------NEGVATYAAAVL---FRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLD 699
                      :..|||.|||::   ..:..|.|:|     ::.|.|.|.          |::|:.
  Fly   531 DIKDYKVILMDATVATGAAAMMAIRVLLDHDVPED-----NIILASLLM----------AEIGVH 580

Human   700 IGAQGEP---LGYRQDDPSYRS-FH----SGGYGQDALGMDPMMEH 737
            ..|...|   :.....||...| |:    .|.:|....|.:|..|:
  Fly   581 SIAYAFPKVKIVTSALDPEINSKFYVIPGIGNFGDRYFGTEPSDEY 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTNNB1	NP_001895.1	Interaction with VCL. /evidence=ECO:0000250	2..23
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..57
		CTNNAbd_CTNNB1	78..151	CDD:439241
		SRP1	142..>431	CDD:227396	35/156 (22%)
		ARM 1	151..191
		armadillo repeat	153..178	CDD:293788
		Interaction with BCL9. /evidence=ECO:0000269|PubMed:17052462	156..178
		armadillo repeat	188..221	CDD:293788
		ARM 2	193..234
		armadillo repeat	230..262	CDD:293788
		ARM	230..262	CDD:214547
		ARM 3	235..276
		armadillo repeat	270..306	CDD:293788	7/26 (27%)
		ARM 4	277..318		9/39 (23%)
		armadillo repeat	312..347	CDD:293788	7/38 (18%)
		ARM 5	319..360		9/44 (20%)
		ARM	350..390	CDD:214547	7/39 (18%)
		armadillo repeat	354..389	CDD:293788	7/34 (21%)
		ARM 6	361..389		6/27 (22%)
		ARM 7	400..441		10/40 (25%)
		armadillo repeat	402..427	CDD:293788	6/24 (25%)
		Arm	431..473	CDD:425727	9/41 (22%)
		armadillo repeat	435..473	CDD:293788	9/37 (24%)
		ARM 8	442..484		9/41 (22%)
		armadillo repeat	482..517	CDD:293788	12/43 (28%)
		ARM 9	489..530		13/49 (27%)
		armadillo repeat	524..582	CDD:293788	11/61 (18%)
		ARM 10	531..571		10/43 (23%)
		Arm	583..622	CDD:425727	4/38 (11%)
		armadillo repeat	587..621	CDD:293788	4/33 (12%)
		ARM 11	594..636		4/41 (10%)
		armadillo repeat	629..662	CDD:293788	9/48 (19%)
		ARM 12	637..666		9/44 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	705..781		10/41 (24%)
		Interaction with SCRIB. /evidence=ECO:0000250	772..781
l(2)k01209	NP_725672.2	UMPK	188..387	CDD:238981	46/204 (23%)
		UPRTase	417..620	CDD:434124	49/258 (19%)