Protein Alignment CTNNB1 and ctnnb1

DIOPT Version :10

• Sequence 1: NP_001895.1
• Gene: CTNNB1 / 1499
• HGNCID: 2514
• Length: 781
• Species: Homo sapiens
• Sequence 2: XP_005157888.1
• Gene: ctnnb1 / 30265
• ZFINID: ZDB-GENE-980526-362
• Length: 789
• Species: Danio rerio
• Alignment Length: 790
• Identity: 761/790 - (96%)
• Similarity: 774/790 - (97%)
• Gaps: 10/790 - (1%)

Human     1 MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYE 65
            ||||:|||||:|||:||||||||||||||||||||||||||||||||||||||::||| :|||||
Zfish     1 MATQSDLMELEMAMDPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEDDDVD-NQVLYE 64

Human    66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQ 130
            |||||:|||.||||||||||||||||||||||||||||||||||||||||:||||||||||||||
Zfish    65 WEQGFNQSFNQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDSAHPTNVQRLAEPSQ 129

Human   131 MLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   130 MLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMV 194

Human   196 SAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLH 260
            |||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Zfish   195 SAIVRTMQNTNDVETARCTSGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLH 259

Human   261 NLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALV 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   260 NLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALV 324

Human   326 NIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSD 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   325 NIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSD 389

Human   391 AATK---------QEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEA 446
            ||||         ||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   390 AATKQTSLAEVDVQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEA 454

Human   447 LVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATV 511
            ||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
Zfish   455 LVRTVLRAGDREDITEPAICALRHLTSRHQDAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATV 519

Human   512 GLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGA 576
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   520 GLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGA 584

Human   577 LHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLT 641
            |||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   585 LHILARDIHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLT 649

Human   642 ELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEP 706
            |||||||||||||||||||||||||||||||||||||||||||||||.||||.||||||||||||
Zfish   650 ELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMTWNETGDLGLDIGAQGEP 714

Human   707 LGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDS 771
            ||||||||||||||||||||||:||||||||||.|||||.||||||||||||.|||:||||||||
Zfish   715 LGYRQDDPSYRSFHSGGYGQDAMGMDPMMEHEMAGHHPGPDYPVDGLPDLGHTQDLIDGLPPGDS 779

Human   772 NQLAWFDTDL 781
            ||||||||||
Zfish   780 NQLAWFDTDL 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTNNB1	NP_001895.1	Interaction with VCL. /evidence=ECO:0000250	2..23		17/20 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..57		20/22 (91%)
		CTNNAbd_CTNNB1	78..151	CDD:439241	71/72 (99%)
		SRP1	142..>431	CDD:227396	287/297 (97%)
		ARM 1	151..191		39/39 (100%)
		armadillo repeat	153..178	CDD:293788	24/24 (100%)
		Interaction with BCL9. /evidence=ECO:0000269|PubMed:17052462	156..178		21/21 (100%)
		armadillo repeat	188..221	CDD:293788	31/32 (97%)
		ARM 2	193..234		39/40 (98%)
		armadillo repeat	230..262	CDD:293788	31/31 (100%)
		ARM	230..262	CDD:214547	31/31 (100%)
		ARM 3	235..276		40/40 (100%)
		armadillo repeat	270..306	CDD:293788	35/35 (100%)
		ARM 4	277..318		40/40 (100%)
		armadillo repeat	312..347	CDD:293788	34/34 (100%)
		ARM 5	319..360		40/40 (100%)
		ARM	350..390	CDD:214547	39/39 (100%)
		armadillo repeat	354..389	CDD:293788	34/34 (100%)
		ARM 6	361..389		27/27 (100%)
		ARM 7	400..441		40/40 (100%)
		armadillo repeat	402..427	CDD:293788	24/24 (100%)
		Arm	431..473	CDD:425727	41/41 (100%)
		armadillo repeat	435..473	CDD:293788	37/37 (100%)
		ARM 8	442..484		40/41 (98%)
		armadillo repeat	482..517	CDD:293788	34/34 (100%)
		ARM 9	489..530		40/40 (100%)
		armadillo repeat	524..582	CDD:293788	57/57 (100%)
		ARM 10	531..571		39/39 (100%)
		Arm	583..622	CDD:425727	37/38 (97%)
		armadillo repeat	587..621	CDD:293788	33/33 (100%)
		ARM 11	594..636		41/41 (100%)
		armadillo repeat	629..662	CDD:293788	32/32 (100%)
		ARM 12	637..666		28/28 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	705..781		70/75 (93%)
		Interaction with SCRIB. /evidence=ECO:0000250	772..781		8/8 (100%)
ctnnb1	XP_005157888.1	CTNNAbd_CTNNB1	77..150	CDD:439241	71/72 (99%)
		SRP1	141..>455	CDD:227396	303/313 (97%)
		armadillo repeat	152..177	CDD:293788	24/24 (100%)
		armadillo repeat	187..220	CDD:293788	31/32 (97%)
		armadillo repeat	229..261	CDD:293788	31/31 (100%)
		ARM	229..261	CDD:214547	31/31 (100%)
		armadillo repeat	269..305	CDD:293788	35/35 (100%)
		armadillo repeat	311..346	CDD:293788	34/34 (100%)
		ARM	349..389	CDD:214547	39/39 (100%)
		armadillo repeat	353..389	CDD:293788	35/35 (100%)
		armadillo repeat	410..435	CDD:293788	24/24 (100%)
		Arm	439..481	CDD:425727	41/41 (100%)
		armadillo repeat	443..481	CDD:293788	37/37 (100%)
		armadillo repeat	490..525	CDD:293788	34/34 (100%)
		armadillo repeat	532..590	CDD:293788	57/57 (100%)
		Arm	593..630	CDD:425727	36/36 (100%)
		armadillo repeat	595..629	CDD:293788	33/33 (100%)
		armadillo repeat	637..670	CDD:293788	32/32 (100%)