DRSC/TRiP Functional Genomics Resources

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Protein Alignment CTNNB1 and hmp-2

DIOPT Version :10

Sequence 1:NP_001895.1 Gene:CTNNB1 / 1499 HGNCID:2514 Length:781 Species:Homo sapiens
Sequence 2:NP_001252425.1 Gene:hmp-2 / 173338 WormBaseID:WBGene00001979 Length:704 Species:Caenorhabditis elegans


Alignment Length:817 Identity:249/817 - (30%)
Similarity:386/817 - (47%) Gaps:181/817 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    29 SYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQR 93
            ||||     |..|     ..:|.....::.|:.:|:. ...:| .||..:|.        ||..|
 Worm     5 SYLD-----GCGT-----KNRGIYRSCELPTTMLLHS-TNSYS-IFTDHEVE--------TRTSR 49

Human    94 VRAAMFPETLDEGMQIPSTQFDAAHPTN-----VQRLAEPSQMLKHAVVNLINYQDDAELATRAI 153
            :|:||||:      .||.|  .||..||     |:.:..|:|.||.:|::|:.|:...:::..::
 Worm    50 IRSAMFPD------WIPPT--SAAEATNSTTSIVEMMQMPTQQLKQSVMDLLTYEGSNDMSGLSL 106

Human   154 PELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSP-----QMVSAIVRTMQNTNDVETARC 213
            |:|.||:.|.|:.||.:|....:.||:::.:   ...:|     ..|.|::...:::| |...|.
 Worm   107 PDLVKLMCDHDESVVARAVHRAYMLSREDPN---FFNAPGFDHRSFVEALMAASKSSN-VNVRRN 167

Human   214 TAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGG 278
            ..|.|.::|..|.|.|.||:|||:..:::||...::||:.||:|||.|||:|...::...|....
 Worm   168 AIGALSHMSEQRGGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNA 232

Human   279 LQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYT-YEKLLWTTSR 342
            ::.:...|:|||.|.||...|.|..|...:..||:..|:..|||.||:|:|.|: :.||::|..|
 Worm   233 VEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREYSDHRKLIYTVVR 297

Human   343 VLKVLSVCSSNKPAIVEAGGMQALGLHL-TDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLV 406
            .::.||||.|||||::..|.:.||.:.| |...:|.....|..:|||||:||.:|.:..|:..|:
 Worm   298 CIRSLSVCPSNKPALISLGCLPALYVELCTAKDERSQTAILVAMRNLSDSATNEENLTQLIIKLL 362

Human   407 QLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHL 471
            :::...:..:..||.|.||||||||.:||..||..|||:|||..:.|..:.|::||||:|||||.
 Worm   363 EIIRVANDGMTACACGTLSNLTCNNTRNKQTVCSHGGIDALVTAIRRLPEVEEVTEPALCALRHC 427

Human   472 TSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRL 536
            |:||..||.||:.:|.....||::..|. ....|:|||.:|:|||.||...|            |
 Worm   428 TARHSLAEEAQSELRFCQAFPVILDQLE-TLRTPVIKAALGVIRNSALLQTN------------L 479

Human   537 VQLLVRAHQDTQRRTSMGGTQQQF-------------------VEGVRMEEIVEGCTGALHILAR 582
            ::|       ||.:|:.|.|....                   |:||.|..::||...|||.||.
 Worm   480 IEL-------TQEQTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVSALHQLAN 537

Human   583 DVHNRIVIRGLNTI--------PLFVQLLYSPI----------ENIQRVAAGVLCELAQDKEAAE 629
              |..:.....:.|        |.|:.||:..:          |.::|...|:|.:|::..:.|.
 Worm   538 --HPAVAAACCDDIGQVGNPECPPFLDLLHRLLAHPRLGSMDDEVLEREILGLLYQLSKRPDGAR 600

Human   630 AIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETA 694
            |:|:.|.:|.|.|...|:.:.|.|||..||                    |:|.|.:..|     
 Worm   601 AVESTGVSALLMESRGSQYKSVVTYANGVL--------------------SNLKRGDSAA----- 640

Human   695 DLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLP----- 754
                                             .:.|....::||.|  ..||:..|||.     
 Worm   641 ---------------------------------IMNMSNSYDYEMSG--SAADWQRDGLERELFA 670

Human   755 ------DLGHAQDLMDGLPPGDSNQLA----WFDTDL 781
                  |.||::.:...|   :::|:.    |:||||
 Worm   671 EMYPTNDGGHSESINMAL---NNSQMRPNHNWYDTDL 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CTNNB1NP_001895.1 Interaction with VCL. /evidence=ECO:0000250 2..23
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..57 3/22 (14%)
CTNNAbd_CTNNB1 78..151 CDD:439241 24/77 (31%)
SRP1 142..>431 CDD:227396 103/295 (35%)
ARM 1 151..191 11/39 (28%)
armadillo repeat 153..178 CDD:293788 9/24 (38%)
Interaction with BCL9. /evidence=ECO:0000269|PubMed:17052462 156..178 8/21 (38%)
armadillo repeat 188..221 CDD:293788 8/37 (22%)
ARM 2 193..234 13/40 (33%)
armadillo repeat 230..262 CDD:293788 14/31 (45%)
ARM 230..262 CDD:214547 14/31 (45%)
ARM 3 235..276 16/40 (40%)
armadillo repeat 270..306 CDD:293788 11/35 (31%)
ARM 4 277..318 13/40 (33%)
armadillo repeat 312..347 CDD:293788 14/35 (40%)
ARM 5 319..360 21/41 (51%)
ARM 350..390 CDD:214547 16/40 (40%)
armadillo repeat 354..389 CDD:293788 12/35 (34%)
ARM 6 361..389 9/28 (32%)
ARM 7 400..441 17/40 (43%)
armadillo repeat 402..427 CDD:293788 6/24 (25%)
Arm 431..473 CDD:425727 22/41 (54%)
armadillo repeat 435..473 CDD:293788 20/37 (54%)
ARM 8 442..484 24/41 (59%)
armadillo repeat 482..517 CDD:293788 12/34 (35%)
ARM 9 489..530 14/40 (35%)
armadillo repeat 524..582 CDD:293788 17/76 (22%)
ARM 10 531..571 11/58 (19%)
Arm 583..622 CDD:425727 10/56 (18%)
armadillo repeat 587..621 CDD:293788 9/51 (18%)
ARM 11 594..636 13/59 (22%)
armadillo repeat 629..662 CDD:293788 13/32 (41%)
ARM 12 637..666 10/28 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 705..781 17/90 (19%)
Interaction with SCRIB. /evidence=ECO:0000250 772..781 4/12 (33%)
hmp-2NP_001252425.1 CTNNAbd_CTNNB1-like 40..103 CDD:439240 24/78 (31%)
HEAT 105..255 CDD:441023 50/153 (33%)
HEAT repeat 106..137 CDD:293787 11/30 (37%)
HEAT repeat 149..177 CDD:293787 7/28 (25%)
armadillo repeat 185..216 CDD:293788 14/30 (47%)
armadillo repeat 224..260 CDD:293788 11/35 (31%)
armadillo repeat 275..302 CDD:293788 11/26 (42%)
Arm 305..346 CDD:425727 16/40 (40%)
armadillo repeat 309..349 CDD:293788 15/39 (38%)
SRP1 <311..>394 CDD:227396 31/82 (38%)
armadillo repeat 358..383 CDD:293788 6/24 (25%)
Arm 387..429 CDD:425727 22/41 (54%)
armadillo repeat 391..429 CDD:293788 20/37 (54%)
armadillo repeat 438..471 CDD:293788 11/33 (33%)
Blue background indicates that the domain is not in the aligned region.

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