Protein Alignment CTNNA1 and Sry-alpha

DIOPT Version :10

• Sequence 1: NP_001894.2
• Gene: CTNNA1 / 1495
• HGNCID: 2509
• Length: 906
• Species: Homo sapiens
• Sequence 2: NP_524580.1
• Gene: Sry-alpha / 43571
• FlyBaseID: FBgn0003510
• Length: 530
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 112/568 - (19%)
• Similarity: 208/568 - (36%)
• Gaps: 168/568 - (29%)

Human   224 ASQACLQHPDVAAYKANRDL--IYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFD 286
            ||....:.|:||...||.|:  |:..|.|.||.|:: .:.|.|.:|.               :..
  Fly    39 ASDLKARLPEVAPSGANLDVETIFLCLTQVVTCITH-LERTISMEAP---------------HMT 87

Human   287 KQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTR---------DDRRERIVAECN---- 338
            :|..:|.|.:...|...||.: ||..::....:.|.|...         ||..|::..:.|
  Fly    88 RQHFLDRLDWCLRRLLVSLTQ-LEGNVTPVKNLEDHSFVELMDLALDHLDDYMEKLAQQRNNSLH 151

Human   339 -------------------AVRQAL------------------QDLLSEYMGNAGRKERSDALNS 366
                               .||.||                  :.||:|.   |...|.:...||
  Fly   152 ILEESFTEDTYQLASIVNHIVRHALAFANVAIHSDKKALTALCETLLAEC---ATFHEEAGEPNS 213

Human   367 AIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVL------------IEAAKNGNEKE---V 416
            ...|:  :...|.|.|      :..:|||  |..||.|            :|..|:..:::   .
  Fly   214 GHRKL--EALSLERAL------YALESFL--NEALLHLLFVSLIDLENASVEKLKDALQRDPAGA 268

Human   417 KEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQ 481
            :|....|..:.:::.::..||.:.|.:.:...:||...:.||:|...:: .||.|   |:|..:.
  Fly   269 QELISAFDTNMDRIQQIGVLAIAFSQDIKTKTIVRSCLASLESLDACIV-PALQL---PESTSSA 329

Human   482 ENMDLFKEQWEKQV----RVLTDAVDDITSIDDFL-AVSENHILEDVNKCVIALQEKDVDGLDRT 541
            .:.::.:|.:.:::    .|:.:.:|..:.|:::| .:.|...::|.:...:.:|
  Fly   330 HHAEVLQEHFNQELLIFRNVIHEIIDSCSLINNYLDMLGERIHVQDKSHLKLIVQ---------- 384

Human   542 AGAIRGRAARVIHVVTSEMDNYE-PGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQP 605
                ||...         :|::. |..|:....:..::..:.::  ...:.:|.|..     ..|
  Fly   385 ----RGGVV---------VDHFRLPVNYSGLSEDGKRVHKDLIL--ILRECQAVVNL-----DVP 429

Human   606 MDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDS--------DFETEDFDVRSRTSVQTEDDQ 662
            :|....:...:::|..:..:|.  |:.|...|.|.|        ...|..| |||..|.
  Fly   430 VDPKRIVKRLKILYSVLAKLRD--LICRDNLEPDSSVASEAQVPSSATRTF-VRSSRSF------ 485

Human   663 LIAGQSARAIMAQL-------PQEQKAKIA---EQVASFQ-EEKSKLD 699
               |:..|:.:.|.       ||:..|:..   ..:.||| .|..:||
  Fly   486 ---GKRHRSFVKQTGNCSVFGPQDSLAESGHSESDLISFQITEILRLD 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTNNA1	NP_001894.2	Involved in homodimerization	2..228		2/3 (67%)
		Vinculin	19..867	CDD:460040	112/568 (20%)
		Interaction with JUP and CTNNB1. /evidence=ECO:0000269|PubMed:9152027	97..148
		Interaction with alpha-actinin	325..394		19/118 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	864..894
Sry-alpha	NP_524580.1	Serendipity_A	1..530	CDD:368466	110/566 (19%)