DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CTNNA1 and alpha-Cat

DIOPT Version :9

Sequence 1:NP_001310911.1 Gene:CTNNA1 / 1495 HGNCID:2509 Length:906 Species:Homo sapiens
Sequence 2:NP_524219.1 Gene:alpha-Cat / 40517 FlyBaseID:FBgn0010215 Length:917 Species:Drosophila melanogaster


Alignment Length:911 Identity:562/911 - (61%)
Similarity:716/911 - (78%) Gaps:17/911 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     2 TAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVE 66
            |....|.|..|||||:|||||::||:.|||||.||||||||  ||||.||:|:||:|..|.|:||
  Fly     9 TLTDFGQIALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVNT--KGPSKKKKGKSKRASALVAAVE 71

Human    67 QATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARAL 131
            :|||||::||::||.|:..:.:|::.||::|:|.||.|..||.||::|||||:||||||||||.|
  Fly    72 KATENFIQKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNL 136

Human   132 LSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQ 196
            |||||||||||||.||:.||..|.:|||.:.||:||.::.:|....:.......:|...||||||
  Fly   137 LSAVTRLLILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQ 201

Human   197 ELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQA 261
            ||||...||.:||||.:|:|:..:|.|||:..::||::...|.|||.|.||:..||..||:.||.
  Fly   202 ELKDPQLRDDLAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQG 266

Human   262 TASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTR 326
            .:|.....:  .|.||||.||::||:.|::||:::||:|.|..||||||||||.||||||:.|||
  Fly   267 KSSQPTDIY--SGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTR 329

Human   327 DDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVS 391
            |:||||||||||||||||||||||||.|..:|:.|..|:.|||:|.:|||||||||||||:||||
  Fly   330 DERRERIVAECNAVRQALQDLLSEYMSNMSQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVS 394

Human   392 DSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQ 456
            ||||||..|||.||||||:||||:|:|.:::|.:||.||:|||||.||:||||:|||:||.:|:|
  Fly   395 DSFLETTTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQ 459

Human   457 LEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILE 521
            :|:|||||||||..|..:|.||:|||||..:::.||.|||:||:||||||:||||||||||||||
  Fly   460 IESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILE 524

Human   522 DVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPR 586
            ||||||:|||..|...|..|||||:||::||.:||.:|||||||.:||::||||.|:|.:.||.:
  Fly   525 DVNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMK 589

Human   587 FTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELD-DSDFE-TED-- 647
            |.::|.|||.|||::..:.:|||:|||||||||||:|:||:||||.|:.|:|| |::|| .||  
  Fly   590 FDQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDLT 654

Human   648 FDVRSRTSVQTEDDQL-----IAG-QSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWD 706
            .:.|||:|..|.|..:     |:| .:||..|.::.:|.|.|||:||..|:.||...|:||:|||
  Fly   655 LETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEVAKWD 719

Human   707 DSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSA 771
            |:|||||.|||.||||||||||||||:||||.|.|||:|||||:|||:::|||.|.||:.||:|:
  Fly   720 DTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQCPESS 784

Human   772 CKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKAS 836
            .|:|||||||||||||||:.|.|||||:|||:.|||:|||:|||.||||||||||||||.|||.|
  Fly   785 TKKDLLAYLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLTVKYS 849

Human   837 YVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFK 901
            |||||||.: ||  :::.|.|.||||||||||||:.||.:|.:.|:::.||||..||:.|||||:
  Fly   850 YVASTKYTR-QG--TVSSPIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQ 911

Human   902 A 902
            :
  Fly   912 S 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CTNNA1NP_001310911.1 Involved in homodimerization 2..228 129/225 (57%)
Vinculin 82..867 CDD:395830 491/794 (62%)
Interaction with JUP and CTNNB1. /evidence=ECO:0000269|PubMed:9152027 97..148 39/50 (78%)
Interaction with alpha-actinin 325..394 53/68 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 864..894 16/29 (55%)
alpha-CatNP_524219.1 Vinculin 87..877 CDD:395830 491/794 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 672 1.000 Domainoid score I144
eggNOG 1 0.900 - - E1_KOG3681
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1087 1.000 Inparanoid score I241
Isobase 1 0.950 - 0 Normalized mean entropy S3027
OMA 1 1.010 - - QHG56187
OrthoDB 1 1.010 - - D405587at33208
OrthoFinder 1 1.000 - - FOG0002407
OrthoInspector 1 1.000 - - otm42067
orthoMCL 1 0.900 - - OOG6_103558
Panther 1 1.100 - - O PTHR18914
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1596
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.790

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