DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gucy2e and Gyc76C

DIOPT Version :9

Sequence 1:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1219	Identity:	370/1219 - (30%)
Similarity:	554/1219 - (45%)	Gaps:	196/1219 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    32 RWPRPGLPGLLLLLLLPSPSALSAVFKVGVLGPWACDPIFARARPDL----AARLAANRLNRDFA 92
            |||...|  |||.:.:...|....|..||.|.....|   .:.|..|    |..:|.:.:|:|
  Fly     3 RWPFNLL--LLLSVAVRDCSNHRTVLTVGYLTALTGD---LKTRQGLAISGALTMALDEVNKD-- 60

Mouse    93 LDGGPRFEVALLPEPCL------TPGSLGAVSSALSR-----VSGLVGPVNPAACRPAELLAQEA 146
                |.    |||...|      |.|.....:.|::.     ::.:.||..|  |....:::|..
  Fly    61 ----PN----LLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGP--CYVEAIVSQSR 115

Mouse   147 GVALVPWGCPGTRAA-----GTTAPAVTPAADALYVLLRAFRWARVALITAPQDLWVEAGRALST 206
            .:.::.:.|...||:     ..|.|..|....:|..|||.:.|.:.:::.  :|:|......|..
  Fly   116 NIPMISYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY--EDVWSPVADLLKD 178

Mouse   207 ALRARGLPVALVTSMETSDRSGAREALGRIRDG---PRVRGKLPSRVRAR-WVGPAES----GQR 263
            ....|.:.:....|...:......:.|...|.|   ..|:..: :|.|.. ::|.|.|    ...
  Fly   179 QATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTM-NRTRIYVFLGAANSLVDFMSS 242

Mouse   264 SEPASVSVRSAVVIMVMHSVLLGGEEQRYLLEAAEELALTDGSLVFLPFDTLHYALSPGPEALAA 328
            .|.|.:..|...:::.:..::....|....|...:::..         ....|           :
  Fly   243 METAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITF---------MSNCH-----------S 287

Mouse   329 FVNSSQLRRAHDAVLTLTRRCPPGGSVQDSLRRAQEHQELPLDLNL------------KQVSPLF 381
            ..|.:|:.|:    |.:....||........::.|::...| ..||            |.:|...
  Fly   288 TENFNQMARS----LLVVASTPPTKDYIQFTKQVQKYSSKP-PFNLEIPRLFVESNFSKFISIYA 347

Mouse   382 GTIYDAVFLLAGGV-----KRARTAVGGGWVSGASVARQVREAQVSG--FCGVLGRTEEPSFVLL 439
            ..:||:|.|.|..|     :..|..........||...:|.:..:..  :..:.|     |.:.:
  Fly   348 AYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITG-----SKIKI 407

Mouse   440 DTDASGEQLFAT------------------HLLDPVLGSLRSAGTP--------MHFPRGGPAPG 478
            |.....|..|:.                  |:: ||....:....|        :.:|.||..|.
  Fly   408 DQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMV-PVAYFHQGEEHPEYKLINGSIDWPSGGEKPA 471

Mouse   479 PDPSCWFDPDVICNGGVE----PGLVFVGFLLVIGMGLTGAFLAHYLRHRLLHMQMASGPNKIIL 539
            .:|.|.|..::.......    ...|.:|.||.....:|.:....:               ||.|
  Fly   472 DEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKW---------------KIEL 521

Mouse   540 TLEDVTFLHPPG---GSSRKVVQGSRSSLATRSASDIRSVPSQPQESTNVGLYEGDWVWLK--KF 599
            .:|.:.:...|.   |.|...:..|.|.::..||....|..:. |..|:.|...|..|.:|  ||
  Fly   522 EIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTN-QFVTSTGRLRGAVVRIKELKF 585

Mouse   600 PGEHHMAIRPATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDL 664
            |.:..:: |...| ....||||||:|:..::|..:..|.          :.:|:::||:|||:|:
  Fly   586 PRKRDIS-REIMK-EMRLLRELRHDNINSFIGASVEPTR----------ILLVTDYCAKGSLYDI 638

Mouse   665 LAQREIKLDWMFKSSLLLDLIKGMRYLHH-RGVAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEA- 727
            :...:||||.:|.:||:.||||||.|:|: :.|.||.|||.||||..|::|:|||.|...|.:.
  Fly   639 IENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCA 703

Mouse   728 -QRVLPEPPSAEDQLWTAPELLRDPSLERRGTLAGDVFSLAIIMQEVVCRSTPYAMLELTPEEVI 791
             ...:.|.....:|||.||||||:   ...|:..|||::.||||.|:..|..|:..:...|:|::
  Fly   704 ENESIGEHQHYRNQLWRAPELLRN---HIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIV 765

Mouse   792 QRVRSPP--------PLCRPLVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKT 848
            ..|:..|        |....::..:..|...:..:..||||.||.||...:..:..|.:..|:..
  Fly   766 DYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTK 830

Mouse   849 NIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEV 913
            ||:|.|:.|:|:|::||||::.|||..|.:||.||:.||.:|||.||||.|.||..|||..::.|
  Fly   831 NIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLV 895

Mouse   914 TLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQR 978
            |:|||||||||.:||.|.|::||:.||||||:||.||..:||||||||||||||.||||.:||.|
  Fly   896 TIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDR 960

Mouse   979 HAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRM 1043
            ||.|||:|:|::|.||...|:.|.|...:::|||:|:||.|||||||||||||||||||||||||
  Fly   961 HAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRM 1025

Mouse  1044 ESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWLVGRLG------------- 1095
            ||.|...:||::......|..|..|:..|.||...:||||...|:||.|...
  Fly  1026 ESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDM 1090

Mouse  1096 ----FNKPIPKPPDLQPGASNHGISLQEI---PPERRKKLEKARPGQFT 1137
                |::| .|.|.|.|.:....|.....   ...|:..:.:|..|:.|
  Fly  1091 PPPLFSRP-RKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGEST 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594	84/471 (18%)
		PK_GC-2D	570..845	CDD:270945	97/287 (34%)
		HNOBA	<854..899	CDD:400168	25/44 (57%)
		CYCc	879..1070	CDD:214485	119/190 (63%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	84/467 (18%)
		ANF_receptor	48..412	CDD:279440	73/408 (18%)
		PK_GC-A_B	543..827	CDD:270944	100/299 (33%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	119/191 (62%)
		Guanylate_cyc	887..1074	CDD:278633	113/186 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810