DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gucy2d and Gyc76C

DIOPT Version :9

Sequence 1:	NP_001124165.1	Gene:	Gucy2d / 14918	MGIID:	106030	Length:	1117	Species:	Mus musculus
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1203	Identity:	381/1203 - (31%)
Similarity:	557/1203 - (46%)	Gaps:	214/1203 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse    56 WADSLSLLAWA--------RETFTLGVLGPWDCDPIFAQALP-SIATQLAVDQVNQDASLLPGSQ 111
            |..:|.||...        |...|:|.|.....|....|.|. |.|..:|:|:||:|.:|||...
  Fly     4 WPFNLLLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVY 68

Mouse   112 LDFKVLPTGCDTPHALATFVAHKNI---VAAFVGPVNPGFCSAAALLAQGWGKSLFSWACEAPEG 173
            ||.:...|..||  .|||....:.|   :|...||..|  |...|:::|.....:.|:.|  .|.
  Fly    69 LDLRWNDTKGDT--VLATKAITEMICDGIATIFGPEGP--CYVEAIVSQSRNIPMISYKC--AEY 127

Mouse   174 GGDLVPTL----PSAADV---LLSVMRHFGWARWAIVSSHQDIWVTTAQQLATAFRTHGLPIGLV 231
            ....:||.    |....|   ||:::|::.|.:::|:  ::|:|...|..|........:.|...
  Fly   128 RASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL--YEDVWSPVADLLKDQATKRNMTINHK 190

Mouse   232 TSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTL------LHCAWEEGLTD----- 285
            .|.   .....:.|:|:         :.|..|.....|.|.|:      :.......|.|
  Fly   191 QSF---IDNRVKCCEQM---------LDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSM 243

Mouse   286 --------GRLVFLPYDTLLFALPYGNR---SYLVLDDHGPL-----------QEAYDAVLTVSL 328
                    |..:.:..|.::    |..|   .||...|....           |.|...::..|.
  Fly   244 ETAGLFARGEYMVIFVDMMV----YSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVAST 304

Mouse   329 ESSPESHAFT--ATEMSGGATANLE----------PEQVSPLFGTIYDAVILLAHALN---RSET 378
            ..:.:...||  ..:.|.....|||          .:.:|.....:||:|.|.|.|::   |.||
  Fly   305 PPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREET 369

Mouse   379 HGAGLSGAHLGDHVRALDVAGFSQRI-------RT----DGKGRRLAQYVILDTDGEGSQL---- 428
            .       .|.|.| ..:||....|:       ||    .|...::.||.  |::|..|.|
  Fly   370 R-------VLTDDV-IFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYG--DSEGNFSVLAYKP 424

Mouse   429 --------VPT--HILDTSTW-------QVQPLGKPIHFP-GGSPPAHDASCWFDPNTLCIRGVQ 475
                    :|.  |::..:.:       :.:.:...|.:| ||..||.:..|.| .|.||.:...
  Fly   425 HKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGF-ANELCKKDDT 488

Mouse   476 PLGSLLTLTIACVLALVGGFLA------YFIRLGLQQLRLLRGPHRILLTSQELTFLQRTPSRRR 534
            ...|.:...:..||....|.:.      :.|.|.::.|.....|:.|
  Fly   489 HYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEI------------------ 535

Mouse   535 PHVDSGSESRSVVDGGSPRSVTQGSARSLPA-----FLEHTNVALYQGEWVWLKKFEAGVAPDLR 594
                .|.....:|  .||..|:..||:|..:     |:  |:....:|..|.:|:.:.....|:.
  Fly   536 ----KGYSGNEIV--SSPSKVSLMSAQSYGSRWTNQFV--TSTGRLRGAVVRIKELKFPRKRDIS 592

Mouse   595 PSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLD 659
            ...:..:|.|||:||:|:.:|:|..|.|....:|.::||:|||.|:::||:::||..|.|||:.|
  Fly   593 REIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHD 657

Mouse   660 LIRGLRYLHHRRFP-HGRLKSRNCVVDTRFVLKITDHGYAEF--------LESHCSSRPQPAPEE 715
            ||:|:.|:|:.:.. ||.|||.||||.:|::|::||.|..|.        :..|...|.|
  Fly   658 LIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQ----- 717

Mouse   716 LLWTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPP--------P 772
             ||.||||||.....:.||||::.|||:.|:.:|..|:.......:||:..|...|        |
  Fly   718 -LWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRP 781

Mouse   773 LCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSES 837
            ....::..:..|...:..::.||.|.|::||....|..:.|.:..||..:::|.|:.|:|||:.:
  Fly   782 EVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANN 846

Mouse   838 LEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISAL 902
            |||:|.|||..|..|:.|||.||.:|||.|||..|.||..|||..:|.||||||||||||.:||.
  Fly   847 LEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAE 911

Mouse   903 SEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYA 967
            |.|::||.|||||||:||.::..:||||||||||||||.||||.:||:|||.|||::||::|...
  Fly   912 STPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAV 976

Mouse   968 GNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTV 1032
            ...|:.|.|:..:::|.|:|:||.|||||||||||||||||||||||||||.|...:||:|....
  Fly   977 KQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCK 1041

Mouse  1033 QALLSLDEGYKIDVRGQTELKGKGLEETYWLTG--------KVGFCRPLPTPLSIKPGDPWQDRI 1089
            .||..|..||..:.||...:||||...|:||||        |:.....:|.||..:|..  ..::
  Fly  1042 LALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRK--SPKL 1104

Mouse  1090 NQEIR---------TGFAKARQGLAEPRKSGEA 1113
            |.:.|         .|....||........||:
  Fly  1105 NPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGES 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gucy2d	NP_001124165.1	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	102/464 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..557		5/27 (19%)
		PK_GC-2D	554..818	CDD:270945	92/285 (32%)
		CYCc	855..1044	CDD:214485	118/188 (63%)
		Interaction with NCALD. /evidence=ECO:0000250\|UniProtKB:P51839	874..915		27/40 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1117		5/18 (28%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	102/452 (23%)
		ANF_receptor	48..412	CDD:279440	89/397 (22%)
		PK_GC-A_B	543..827	CDD:270944	95/293 (32%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	118/191 (62%)
		Guanylate_cyc	887..1074	CDD:278633	113/186 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910