Protein Alignment GLIS1 and ztf-14

DIOPT Version :10

• Sequence 1: NP_001377765.1
• Gene: GLIS1 / 148979
• HGNCID: 29525
• Length: 803
• Species: Homo sapiens
• Sequence 2: NP_001360586.1
• Gene: ztf-14 / 187492
• WormBaseID: WBGene00010936
• Length: 483
• Species: Caenorhabditis elegans
• Alignment Length: 627
• Identity: 153/627 - (24%)
• Similarity: 225/627 - (35%)
• Gaps: 248/627 - (39%)

Human   138 LLHF--PHPDRSPRPQATYVN--GSLPTTQHIKQESLPDYQAMAEA----RTSLSAHCRGPLATG 194
            |||.  |:|:..   ..|:.|  .|.|        ||.:|.:|:.|    .|..::....|:.|
 Worm    10 LLHVVPPYPNAL---DVTHQNSGNSSP--------SLHNYSSMSPASSVSNTVYNSSEVSPMGT- 62

Human   195 LHPDLDLPGRSLATPAPSCYLLGSEPSSGLGLQPETHLPEGSLKRCCVLGLPPTSPASSSPCASS 259
                    |.:....||:.:   ..|      :|:.|:         ||          :|..|.
 Worm    63 --------GDASWNKAPNYF---ERP------KPDRHI---------VL----------NPLGSP 91

Human   260 DVTSIIRSSQTSLVTCVNGLRSPPLTGDLGG----------------PSKRARPGPASTDSHEGS 308
            |:.:..:|..:|::..:|.|    :.|..||                |:.: ||..|:|.:..|:
 Worm    92 DIGAQFQSPASSIMNTINSL----VHGSSGGLLQVQQSQYFGPAELNPNLK-RPHDATTSTEFGA 151

Human   309 LQL---------------EACRKASFLKQEPADEFSELFGPHQQGLPPPYPLSQLPPGPSLGGLG 358
            |.:               :..|:.:..|:|..||..::..|.:|              |.|.
 Worm   152 LSVVPIPFDCNQTTGGIEQTIREVATNKRERVDEELDVIIPKKQ--------------PRLS--- 199

Human   359 LGLAGRVVAGRQACRWVDCCAAYEQQEELVRHIEKSHIDQRKGEDF-TCFWAGCVRRYKPFNARY 422
                   |.|::..|....|.|        .:|..:.|.::..||. .|.|.||.   ...:.|.
 Worm   200 -------VNGKRIGRPPGSCKA--------NYIPPTKITEQNDEDVRQCLWDGCT---LTLDDRA 246

Human   423 KLLIHM-------------RVHSGEKPNKCMPFPQFFHEFEGCSKAFSRLENLKIHLRSHTGEKP 474
            ...:|:             |.|:.:|...|          |.|.|.:.||||||.|.|:||||||
 Worm   247 TFFVHVDNHIQKNEVNSHKRTHTKQKLYCC----------EVCPKRYGRLENLKTHRRTHTGEKP 301

Human   475 YLCQHPGCQKAFSNSSDRAKH-QRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKA----HSAKEQ 534
            |.|..|.|.|:|:|:|||:|| :|||.:.|||.|....|:..||||||||||||:    |.|.:.
 Worm   302 YHCNVPNCNKSFTNASDRSKHSKRTHSNEKPYCCDFGSCACAYTDPSSLRKHVKSKHPEHHAMKM 366

Human   535 QVRKKLHAGPDTEADVLTECLVLQQLHTSTQLAASDGKGGCGLGQELLPGVYPGSITPHNGLASG 599
            .:||             |:...::|:
 Worm   367 AMRK-------------TQRKSIKQI--------------------------------------- 379

Human   600 LLPPAHDVPSRHHPLDATTSSHHHLSPLPMAESTRDGLGPGLLSPIVSPLKGLGPPPL---PPSS 661
                              .|....:||||.|..          :|| ||.:.|...||   ||..
 Worm   380 ------------------ASEKVQMSPLPTAAE----------API-SPQQNLPTLPLNMIPPPL 415

Human   662 QSHSP-GGQPFPTLP-SKPSYPPF------QSPPPPPLPSPQ 695
            |:..| ...||..:| :.|:...|      .:||..|.|.||
 Worm   416 QTQLPLRVPPFTGMPFANPALQLFLATQMRMAPPMTPFPLPQ 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLIS1	NP_001377765.1	C2H2 Zn finger	376..395	CDD:275368	3/18 (17%)
		C2H2 Zn finger	406..431	CDD:275368	7/37 (19%)
		COG5048	447..>522	CDD:227381	42/75 (56%)
		C2H2 Zn finger	450..469	CDD:275368	11/18 (61%)
		C2H2 Zn finger	477..499	CDD:275368	12/22 (55%)
		C2H2 Zn finger	507..529	CDD:275368	14/25 (56%)
ztf-14	NP_001360586.1	zf-H2C2_2	260..283	CDD:463886	7/32 (22%)
		zf-C2H2	274..296	CDD:395048	12/31 (39%)
		C2H2 Zn finger	276..296	CDD:275368	12/29 (41%)
		zf-H2C2_2	288..315	CDD:463886	17/26 (65%)
		SFP1	<298..358	CDD:227516	36/59 (61%)
		C2H2 Zn finger	304..327	CDD:275368	12/22 (55%)
		C2H2 Zn finger	335..355	CDD:275368	12/19 (63%)