Protein Alignment CTBP1 and CtBP

DIOPT Version :10

• Sequence 1: NP_001364115.1
• Gene: CTBP1 / 1487
• HGNCID: 2494
• Length: 441
• Species: Homo sapiens
• Sequence 2: NP_001262522.1
• Gene: CtBP / 41602
• FlyBaseID: FBgn0020496
• Length: 481
• Species: Drosophila melanogaster
• Alignment Length: 476
• Identity: 285/476 - (59%)
• Similarity: 337/476 - (70%)
• Gaps: 49/476 - (10%)

Human     1 MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEK 65
            |..:.::.|...:.|:....||||..||||||||||||::|||||||||||||||||||.|||||
  Fly     1 MDKNLMMPKRSRIDVKGNFANGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEK 65

Human    66 VLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETAD 130
            ||||||||||:|||.||:||||||||||||||||||.||||:|:||:|||||||||...|||.||
  Fly    66 VLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVAD 130

Human   131 STLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKA 195
            :|:|.|||||||..||...:|||.:....||:||.|.|.|||||:|||::||||:|.||||||||
  Fly   131 TTMCLILNLYRRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKA 195

Human   196 FGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAF 260
            |||||:||||||.||::::|||.||.|||||||.||||:|||.||||||||||:||:||||.|||
  Fly   196 FGFNVIFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAF 260

Human   261 LVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASI 325
            |||||||||||::.||.|||:||||.|||||||:||::   |.||||||||||||||::|:.::.
  Fly   261 LVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYN---GALKDAPNLICTPHAAFFSDASAT 322

Human   326 EMREEAAREIRRAITGRIPDSLKNCVNKDHL--TAATHWASMDPAVVHPE-LNGA---------A 378
            |:||.||.||||||.|.|||.|:|||||::.  |.....|....|.|:|| |||.         |
  Fly   323 ELREMAATEIRRAIVGNIPDVLRNCVNKEYFMRTPPAAAAGGVAAAVYPEGLNGGYYTGALHHRA 387

Human   379 YSRYP----------PGVVGVAPTGI---------PAAVEGIVPSAMSLSHGLPPVA-------- 416
            :|..|          ...||..||.:         .||...::||.:. ||..|.|.
  Fly   388 HSTTPHDGPHSTTNLGSTVGGGPTTVAQAAAAAVAAAAAAALLPSPVP-SHLSPQVGGLPLGIVS 451

Human   417 --HPPHAPSP----GQTVKPE 431
              .|..||.|    ..::|.|
  Fly   452 SQSPLSAPDPNNHLSSSIKTE 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTBP1	NP_001364115.1	Interaction with GLIS2 1. /evidence=ECO:0000250	1..70		46/68 (68%)
		CtBP_dh	28..346	CDD:240624	240/317 (76%)
		Interaction with GLIS2 2. /evidence=ECO:0000250	288..360		46/73 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..441		10/37 (27%)
CtBP	NP_001262522.1	CtBP_dh	28..342	CDD:240624	239/316 (76%)