DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SAMD11 and spe-44

DIOPT Version :9

Sequence 1:	NP_001372569.1	Gene:	SAMD11 / 148398	HGNCID:	28706	Length:	845	Species:	Homo sapiens
Sequence 2:	NP_502379.1	Gene:	spe-44 / 182915	WormBaseID:	WBGene00007732	Length:	424	Species:	Caenorhabditis elegans

Alignment Length:	242	Identity:	55/242 - (22%)
Similarity:	91/242 - (37%)	Gaps:	40/242 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    42 AAAALPPAASLPASAAGYEALLAPPLRPPRAYLSLHEAAPHLHLPRDPLALERFSATA-----AA 101
            :||::.|:..:..|..|::|                |.:.|.|....|....:.:...     .|
Worm     7 SAASVLPSHPISGSCDGFQA----------------EGSDHHHSTMTPFQESQRNVYQILYGHPA 55

Human   102 APDF-------QPLLDNGE--PCIEVECGANRALLYVRK-LCQGSKGPSIRHRGEWLTPNEFQFV 156
            ..||       |..:..|:  |.:.|.||.....:::.. :|.|...|.|....:.|:|.:|...
Worm    56 NDDFPRPITPLQITIPEGDASPTVPVSCGVVNGKMHLNLFMCPGIHQPCIEVGNDLLSPKQFTIR 120

Human   157 SGRETAKDWKRSIRHKGKSLKTLMSKGILQVHPPICDCPG-CRISSPVNRGR---LADKRTVALP 217
            ..:|..||||.|||....||:|.|....:..:..:..|.| |:..:.||...   |..:::....
Worm   121 GDKERQKDWKASIRVGRSSLRTHMEAMTIDFYEHMNRCSGKCQSRNYVNAPSEEVLQARKSKRTS 185

Human   218 AARNLKKERTPSFSASDGDSDGSGPTCGRRPGLKQEDGPHIRIMKRR 264
            .|..||.|.....:..:.|:|.:     |:...|....|...:.|.|
Worm   186 EAGQLKYEIENEMAGKEADNDDN-----RKSAKKARGRPRGSVNKPR 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SAMD11	NP_001372569.1	SAND	113..185	CDD:396076	23/74 (31%)
SAMD11	NP_001372569.1	SAM_Samd7,11	704..771	CDD:188978
spe-44	NP_502379.1	SAND	77..150	CDD:128554	23/72 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900