Protein Alignment Pdia3 and CaBP1

DIOPT Version :9

• Sequence 1: NP_031978.2
• Gene: Pdia3 / 14827
• MGIID: 95834
• Length: 505
• Species: Mus musculus
• Sequence 2: NP_001285979.1
• Gene: CaBP1 / 34976
• FlyBaseID: FBgn0025678
• Length: 433
• Species: Drosophila melanogaster
• Alignment Length: 496
• Identity: 107/496 - (21%)
• Similarity: 162/496 - (32%)
• Gaps: 240/496 - (48%)

Mouse    14 LLLA------SARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAAT 72
            ||||      ||..:.:..|:|||..||:..|....:  :.:|||:|||||||:.|.|||:..|.
  Fly     8 LLLAFVVGSVSAFYSPSDGVVELTPSNFDREVLKDDA--IWVVEFYAPWCGHCQSLVPEYKKLAK 70

Mouse    73 RLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA-YDGPRTADGIVSHLKKQAGPAS 136
            .|||:|.:..|:..|::....::||.|:||:|||...:::.. |:|.|||..|.
  Fly    71 ALKGVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIA----------- 124

Mouse   137 VPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGE 201
                                                                 |:.:.|
  Fly   125 -----------------------------------------------------EAALAE------ 130

Mouse   202 GITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYD 266
                                          :||.:|..:.|
  Fly   131 ------------------------------VKKKVQGVLGG------------------------ 141

Mouse   267 VDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPVVAIRTA 331
                  ..||                                   |..|..|::|:..:
  Fly   142 ------GGGS-----------------------------------SSGGSGSSSGDDVI------ 159

Mouse   332 KGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKD 396
                     |.:.|                                       |||.:|...|..
  Fly   160 ---------ELTED---------------------------------------NFDKLVLNSDDI 176

Mouse   397 VLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN-DVPSPYEVKGFPTIYFSPANK 460
            .|:||:||||||||||.|::.:..::|.  ..:.:..:||||: ...:.|.|:|:|||.|.||..
  Fly   177 WLVEFFAPWCGHCKNLAPEWAKAAKELK--GKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGS 239

Mouse   461 KLT--PKKYEGGRELNDFISYL-QREATNPP------IIQE 492
            |..  .::|:|||..:|.:|:. .:...|.|      ||.|
  Fly   240 KRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEIINE 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdia3	NP_031978.2	ER_PDI_fam	26..487	CDD:273457	96/465 (21%)
		Thioredoxin	27..131	CDD:278513	42/104 (40%)
		PDI_b_ERp57	135..240	CDD:239367	5/104 (5%)
		PDI_b'_ERp72_ERp57	244..357	CDD:239371	8/112 (7%)
		PDI_a_PDI_a'_C	377..480	CDD:239293	40/105 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..505		5/15 (33%)
		Prevents secretion from ER. /evidence=ECO:0000250	502..505
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	38/94 (40%)
		PDI_a_P5	157..262	CDD:239299	42/160 (26%)
		Thioredoxin_6	190..383	CDD:290560	30/93 (32%)
		P5_C	271..400	CDD:239281	3/10 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910