DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF570 and CG31441

DIOPT Version :9

Sequence 1:	NP_001287922.1	Gene:	ZNF570 / 148268	HGNCID:	26416	Length:	592	Species:	Homo sapiens
Sequence 2:	NP_731558.1	Gene:	CG31441 / 326139	FlyBaseID:	FBgn0051441	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	326	Identity:	80/326 - (24%)
Similarity:	139/326 - (42%)	Gaps:	58/326 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   167 IIETLTSYNLEYSSLREEWKCEGYFERQPGNQKACFK---EEIITHEEPLFDEREQEYKSWGSFH 228
            |:|.:|...||:.:......|:            |.|   :.|:|......:           .|
  Fly    36 ILENITDMYLEFDTTLPHLICQ------------CCKVQLDRILTFRNKCLE-----------VH 77

Human   229 QNPLLCTQKIIPK----EEKVHKHDTQKRSFKKNLMAIKPKSVCAEKK----LL--------KCN 277
            ::.:...:|::.|    :|::.|.|.:|  .:::|.....:.:|....    ||        |..
  Fly    78 KSFMAANRKLLRKKAIVDEELDKPDVEK--LQQDLWDHTDQEMCVAMADTAGLLREDHNDNEKAK 140

Human   278 DCEKVFSQSSSLTLHQRIHTGEKPYKCIE-------CGKAFSQRSNLVQHQRIHTGEKPYECKEC 335
            |.|.......:.....::.|.|..: |.|       ..|..|.|    ..:|.....|.:.|.:|
  Fly   141 DAEDATQNEKNQEEQVQVQTEEVEH-CQEQLHNMSIISKGVSAR----VPKRTKRNSKSWFCDQC 200

Human   336 RKAFSQNAHLVQHLRVHTGEKPYECKVCRKAFSQFAYLAQHQRVHTGEKPYECIECGKAFSNRSS 400
            ...|..:.:|..||:.|:|.||:.|.:|:..:.....:.:|:.:||..:||.|..|.|.:...||
  Fly   201 GGVFKSSTYLKLHLQRHSGHKPFACDICQAKYYTDNEMRRHRILHTDARPYACRFCSKTYRGCSS 265

Human   401 IAQHQRVHTGEKPYECNVCGKAFSLRAYLTVHQRIHTGERPYECKECGKAFSQNSHLAQHQ--RI 463
            ...|:|.||.|:|::|..|.|||:..:....|:.:||.:|.|.|:.|.:.|.::|||..||  ::
  Fly   266 KVVHERTHTNERPFQCQHCDKAFTSTSTRQKHEMLHTNQRKYHCEICDQWFLRSSHLTLHQSTKL 330

Human   464 H 464
            |
  Fly   331 H 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF570	NP_001287922.1	KRAB	70..130	CDD:214630
		C2H2 Zn finger	276..296	CDD:275368	2/19 (11%)
		zf-H2C2_2	288..313	CDD:316026	5/31 (16%)
		C2H2 Zn finger	304..324	CDD:275368	6/26 (23%)
		COG5048	<307..572	CDD:227381	52/160 (33%)
		C2H2 Zn finger	332..352	CDD:275368	6/19 (32%)
		C2H2 Zn finger	360..380	CDD:275368	3/19 (16%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		C2H2 Zn finger	444..464	CDD:275368	8/21 (38%)
		C2H2 Zn finger	472..492	CDD:275368
		C2H2 Zn finger	500..520	CDD:275368
		C2H2 Zn finger	528..548	CDD:275368
		C2H2 Zn finger	556..576	CDD:275368
CG31441	NP_731558.1	zf-AD	7..82	CDD:285071	11/68 (16%)
		COG5048	<174..337	CDD:227381	52/162 (32%)
		C2H2 Zn finger	197..217	CDD:275370	6/19 (32%)
		C2H2 Zn finger	225..245	CDD:275368	3/19 (16%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..290	CDD:290200	11/21 (52%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		C2H2 Zn finger	309..328	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000