DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B3 and CG33298

DIOPT Version :9

Sequence 1:	XP_006722717.1	Gene:	ATP8B3 / 148229	HGNCID:	13535	Length:	1310	Species:	Homo sapiens
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1532	Identity:	435/1532 - (28%)
Similarity:	686/1532 - (44%)	Gaps:	442/1532 - (28%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGTGPAQTPRSTRAGPEPSP---APPGPGDTGDSDVT----QEGSGPAGIRGGETVIRAG----- 53
            ||.|   .|..|...|..:|   :.||.|..|...|.    ..|...:...||..::.|.
  Fly    60 MGAG---EPERTYVFPGGNPVVGSAPGGGGQGIPGVAMAAPSRGHARSISHGGGAIVGANGRPIK 121

Human    54 --------------MGDS-PGRGAPERR----------------HKAQPGRARKYEWRPEGPTSM 87
                          :.|| ||..||..|                ||.:|.|      .|..|||
  Fly   122 SAMKGHQRAFSQGQITDSPPGSAAPAGRGHSRVGSKTDFILPPGHKEEPAR------EPSAPTS- 179

Human    88 GSLGQREDLQDEDRNSAFT---------WKVQANNRAYNGQFKEKVILC-------WQRKKYKT- 135
            .:.|:....|.....|.:|         ||              ::.||       ::.:.|:|
  Fly   180 ATGGRGHSRQASRSESIYTLRRTEAPPWWK--------------RLTLCNYNTGDKFEERSYRTV 230

Human   136 ----------------------NVIRTAKYNFYSFLPLNLYEQFHRVSNLFFLIIIILQSIPDIS 178
                                  |.|||.||...||:|.||.||||||:||:|:.|::|..:|:||
  Fly   231 VPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEIS 295

Human   179 TLPWFSLSTPMVCLLF---IRATRDLVDDMGRHKSDRAINNRPCQILMGKS--FKQKKWQDLCVG 238
            .   |.....|:.:||   :.|.:||.:|..|..||:.|||..|::..|::  :|:.|||:|.||
  Fly   296 A---FGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVG 357

Human   239 DVVCLRKDNIVPADMLLLASTEPSSLCYVETVDIDGETNLKFRQALMVTHKELATIKKMASFQGT 303
            |:|.|..:..||||:|||.:::|..:||::|.|:||||||| |:.::...:|:.:|...:.|...
  Fly   358 DIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLK-RREVVRGFEEMQSIFVPSKFVSR 421

Human   304 VTCEAPNSRMHHFVGCL-EWNDKKYSLDIGNLLLRGCRIRNTDTCYGLVIYAGFDTKIMKNCGKI 367
            |..:||.::::.|.|.| ....::..:....||||..|::|||...|:|:|||.:||.|.|....
  Fly   422 VEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGP 486

Human   368 HLKRTKLDLLMNKLVVVIFISVVLVCLVLAFGFGFSVKEFKDHHYYLSGVHGSSVAA--ESFFVF 430
            ..||::::..||..|:...|.::::|:|.|.|....:..|.  |:.:..:..:.:.|  ||.::|
  Fly   487 RYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFT--HFPVPYLPPNKLTANMESMWIF 549

Human   431 WSFLILLSVTIPMSMFILSEFIYLGNSVFIDWDVQMYYKPQDVPAKARSTSLNDHLGQVEYIFSD 495
            |:::::|.|.||:|:::..|...:.....|..:|.::....:...:.|:.::.:.|||:::||:|
  Fly   550 WTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTD 614

Human   496 KTGTLTQNILTFNKCCISGRVYG-PDSEAT---TRP--KENPYLWN--------KFADGKLLFHN 546
            ||||||:|.:.|.:|.::|..|. |.||..   ::|  ...|.:.|        :...|..|..:
  Fly   615 KTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPH 679

Human   547 AALLHLVRTNGDEAVREFWRLLAICHTVMVRESP----------------------------RER 583
            |           :.::||..:||||:||:|..:|                            |::
  Fly   680 A-----------QRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQK 733

Human   584 ----------------------------------------------PDQL--------------- 587
                                                          |:.|
  Fly   734 LLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPI 798

Human   588 ----------------------------------------------------------------- 587

  Fly   799 SSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKT 863

Human   588 -----------LYQAASPDEGALVTAARNFGYVFLSRT--QDTVTIMELGEERVYQVLAIMDFNS 639
                       ||:|.||||.|||.||.::....|:|:  |..|::...|..|.|::|.::.|:|
  Fly   864 GTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDS 928

Human   640 TRKRMSVLVRK-PEGAICLYTKGADTVIFERL----HR--RGAMEFATEEALAAFAQETLRTLCL 697
            :||.||::||: ....|.|||||||:.|...|    |.  .|.:...|::.|..:|:|.||.|.:
  Fly   929 SRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVM 993

Human   698 AYREVAEDIYEDWQQRHQEASLLLQNRAQALQQVYNEMEQDLRLLGATAIEDRLQDGVPETIKCL 762
            |.|.:....|.||..||||..:.|:||.:.|:..:.::|.:|.|||||.|||||||||||||..|
  Fly   994 AKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASL 1058

Human   763 KKSNIKIWVLTGDKQETAVNIGFACELLSENMLILE---------EKEISRILETYWENSNNLLT 818
            ..:.|.:|||||||.|||:||.::.:|.::.|.::.         |..|:..| |..||.....|
  Fly  1059 LSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYL-TDMENDKTTST 1122

Human   819 ---RESLSQVKLALVINGDFLDKLLVSLRKEPRALAQNVNMDEAWQELGQSRRDFLYARRLSLLC 880
               .:||.:.:.|||::|..|..:|     :|::
  Fly  1123 LGYGQSLRKKQRALVVDGKTLTFIL-----DPKS------------------------------- 1151

Human   881 RRFGLPLAAPPAQDSRARRSSEVLQERAFVDLASKCQAVICCRVTPKQKALIVALVKKYHQVVTL 945
             :..||                      |:.|:.:|.:|:|||.||.|||.:|.:||:...:.||
  Fly  1152 -KLILP----------------------FLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTL 1193

Human   946 AIGDGANDINMIKTADVGVGLAGQEGMQAVQNSDFVLGQFCFLQRLLLVHGRWSYVRICKFLRYF 1010
            ||||||||::||:.||||||::||||||||..:||.|.:|.:|:||||.||.|.|.|:.:.:.||
  Fly  1194 AIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYF 1258

Human  1011 FYKSMASMMVQVWFACYNGFTGQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVSAEQSLEKPELY 1075
            |||:.|.:.:..|:..|.||:||.:.:..:|.|:||::::||.|.||::::.|:.:..|:.|.||
  Fly  1259 FYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLY 1323

Human  1076 VVGQKDELF---NYWVFVQAIAHGVTTSLVNFFMTLWISRDTAGPASFSDHQ----SFAVVVALS 1133
            ..|:....:   ::|:.   :...:..|||.||:.|         .::::..    .|...:..|
  Fly  1324 KNGRLGVAYRPHDFWLI---LLDALYQSLVIFFVAL---------CAYAESDVGIWEFGTTITAS 1376

Human  1134 CLLSITMEVILIIKYWTALCVATILLSLGFYAIMTTTTQSFWLFRVSPTTFPFLYADL-----SV 1193
            ||.:..:...:.|:.||.|.|.:|:||||          ||:||.:       :|..:     .|
  Fly  1377 CLFANLVHCAIEIRSWTVLHVLSIVLSLG----------SFYLFAI-------VYDSVCMNCFGV 1424

Human  1194 MSSPSIL----------LVVLLSVSINTFPVLALRVI 1220
            .||..::          ||::||..:...|.|.|..:
  Fly  1425 RSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTV 1461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B3	XP_006722717.1	PhoLip_ATPase_N	108..184	CDD:292826	30/105 (29%)
		ATPase-Plipid	133..1220	CDD:273734	396/1339 (30%)
		Cation_ATPase	<593..669	CDD:289987	34/78 (44%)
		HAD_like	<931..975	CDD:304363	27/43 (63%)
		PhoLip_ATPase_C	975..1220	CDD:292829	78/266 (29%)
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	26/52 (50%)
		ATPase-Plipid	250..1473	CDD:273734	394/1318 (30%)
		E1-E2_ATPase	302..>394	CDD:278548	38/91 (42%)
		Cation_ATPase	<880..965	CDD:289987	35/84 (42%)
		HAD_like	<1177..1240	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	78/268 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830