Protein Alignment Grin1 and Nmdar1

DIOPT Version :10

• Sequence 1: NP_001359487.1
• Gene: Grin1 / 14810
• MGIID: 95819
• Length: 959
• Species: Mus musculus
• Sequence 2: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Alignment Length: 954
• Identity: 435/954 - (45%)
• Similarity: 617/954 - (64%)
• Gaps: 67/954 - (7%)

Mouse    20 AACDPKIVNIGAVLSTRKHEQMFREAVNQAN--KRHGSWKIQLNATSVTHKPNAIQMALSVCEDL 82
            |:.:|...|||.|||....|:.|...:...|  :::...|:.....::....|.|:...:||:.|
  Fly    32 ASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKL 96

Mouse    83 ISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQ 147
            |.::|||::|||..|..| .:|..||||:|||.|||:|:::|.:.:|||:||:|||||||||.||
  Fly    97 IENRVYAVVVSHEQTSGD-LSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQ 160

Mouse   148 SSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKSKKRNYENLDQLSYDNKRGPKA 212
            :.||.||:..:.:..:|::.|.|.:|||...|.:|        :.:..|:::|..:       ..
  Fly   161 ADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQT--------TSQTYYDDVDVRA-------TV 210

Mouse   213 EKVLQFDPGTKNVTALLMEARDLEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG 277
            |.:::|:|..::.|..|::.:..::||.::.||.:||..::|.|...||||.|:||:|.|:.:..
  Fly   211 ELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFS 275

Mouse   278 NALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLF 342
            |   ..|||::||||.:..::..||.|:|.|:|.|:.|::..|.|.:.|:.|..:...|::|
  Fly   276 N---NTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESG--- 334

Mouse   343 KRVL--MSSKYADGVTGRVEFNEDGDRKFANYSIMNL--QNRKLVQVGIYN------GTHVIPND 397
            ||:.  :.|:...|.||:|.|:::|||.:|.|.::|:  |.:|.| ||.::      ...:..||
  Fly   335 KRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHV-VGKFSYDSMRAKMRMRIND 398

Mouse   398 RKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGD--PVKKVICTGP 460
            .:|||||.:..||.|..:.|.|:::||.::|||||: .|.|    :||....|  |     |...
  Fly   399 SEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVR-RMGD----DEFRCEPDERP-----CPLF 453

Mouse   461 NDTSPGSPRHTVPQCCYGFCVDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSN----KKEWNG 521
            |::...:...    ||.|:|:||||:|::.:||||::.|..||:||.....||:.    :|||.|
  Fly   454 NNSDATANEF----CCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTG 514

Mouse   522 MMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLL 586
            ::|||::.:|||||||||||.|||:||||||||||||:|||.||....|||.||:|||.:|||:|
  Fly   515 LIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWIL 579

Mouse   587 VGLSVHVVAVMLYLLDRFSPFGRFKV-NSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSA 650
            |.:||||||::||||||||||||||: :|:..||.||.||||:||:||||||||||||.||||||
  Fly   580 VMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSA 644

Mouse   651 RILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFR 715
            |:||||||||||||||||||||||||||:||:.:::||||.||||..:....||||.||||:|||
  Fly   645 RVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFR 709

Mouse   716 RQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFG 780
            ||||||.|||.||.:||.:|.:|||.|:..||.||||||:.||:|||:.|:|||.||||.|||:|
  Fly   710 RQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYG 774

Mouse   781 IGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRY----QECDSRSNAPATLTFENMAGVFMLV 841
            ||::|.|||...|:|:||:.||:||||.|||.|:.:    |.|:.....|.||..:||||||:||
  Fly   775 IGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVFILV 839

Mouse   842 AGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKK------AT 900
            ..||..|:.||.||:.||:|:..::|::.:|..|.:.||..::.||:.||....:::      :|
  Fly   840 GVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNST 904

Mouse   901 FRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIE 944
            ....|.:||.. |||........|..|....:..|.:..||..|
  Fly   905 HAPGTISLAVD-KRRYPRLGQRLGPERAWPGDAADVLRIRRPYE 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grin1	NP_001359487.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	135/390 (35%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	249/414 (60%)
		CaM_bdg_C0	856..884	CDD:402271	8/27 (30%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	135/390 (35%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	249/414 (60%)
		CaM_bdg_C0	854..882	CDD:402271	8/27 (30%)