DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik3 and GluRIIC

DIOPT Version :9

Sequence 1:	NP_001074566.1	Gene:	Grik3 / 14807	MGIID:	95816	Length:	919	Species:	Mus musculus
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	923	Identity:	285/923 - (30%)
Similarity:	464/923 - (50%)	Gaps:	115/923 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 WRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINR 69
            |:|: .|:...|:.|.:|.     |||..  |.||..| |.|....      |..|....|.||.
  Fly     2 WQRI-LLLGCMWSAFFMCR-----SRGQQ--INIGAFF-YDDELEL------EKEFMTVVNAING 51

Mouse    70 NRTLLPNTTLTYD-IQRIHFHD-SFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPH 132
            ..:  ..|...|. |:|:...| |....:.|||.:..||.||||||..:.::.|..:||:..:||
  Fly    52 PES--EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPH 114

Mouse   133 ---------IQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVY--DDSTGLI 186
                     ||....:|.:.      :||||..|.||.|..|:||:..||..|:||  ||:....
  Fly   115 IEFDISDEGIQAEKPNHQMT------LNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAA 173

Mouse   187 RLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMM 251
            |||:|:.....:|..:::|:...| ||.|.:.|.: || |.|::.||...|..::|..:...|:.
  Fly   174 RLQDLLQLREVHNDVVRVRKFHKD-DDFRVMWKSI-RG-ERRVVLDCEPNMLVELLNSSTEFGLT 235

Mouse   252 TEYYHFIFTTLDLY-------ALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWAMERLQAAPR 309
            .:|.|...|.|:.|       |.|.|.:   .||:|..|:|...:|...::...:..:|
  Fly   236 GQYNHIFLTNLETYTDHLEELAADNETF---AVNITAARLLVNPDPPPYSLPYGYVTQR------ 291

Mouse   310 AESGLLDGVMMTDA--------ALLYDAVHIVSVCYQRA-----PQMTVNSLQC----HRHKAWR 357
                  |.::...:        .|::||:.:.:..::.|     .:|.|..:.|    ...:.|.
  Fly   292 ------DNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWA 350

Mouse   358 FGGRFMNFIKEAQWEGLTGRIVFNKTSGL-RTDFDLDIISLKEDGLE---KVGVWSPADGLNITE 418
            .|......:|              .|||: .|:|...|:...|||..   .:.|:.|.||:.|.
  Fly   351 MGRYLARLMK--------------GTSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIA- 400

Mouse   419 VAKGRGP----NVTDSLTNRSLI--VTTVLEEPFVMFRKSDR--TLYGNDRFEGYCIDLLKELAH 475
            :...||.    || |....:.:|  |.|.:..|:..:.::.|  .|.||..::||.:||:..:|.
  Fly   401 IWDPRGQITQLNV-DVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIAR 464

Mouse   476 ILGFSYEIRLVEDGKYGAQD-DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLG 539
            .:||.|....|.|.:||..| :..||||::.|:|::.|.:.:..||||..|:.|:||:.|||.||
  Fly   465 HVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLG 529

Mouse   540 VSIL-YRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEV 603
            |||| |:.|: ...::.::|.|...::|:::|::...::.:..::||.|..:|.:.||||...||
  Fly   530 VSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEV 593

Mouse   604 VENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMES 668
            :||.:.:.|:.|..:.|:|..|.:::|::...|:....||.|.:||.:|||||||||||..:||.
  Fly   594 LENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEG 658

Mouse   669 PIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSS-KPSALVKNNEEGIQRTL-- 730
            .|.:..||:.|.|:::|.:..|:|......|..:.:...:..|:: .|||..|:|.||:.|..
  Fly   659 SIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKN 723

Mouse   731 TADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIM 795
            ..||..|||:||:||..::||:|..:|.....|.|.|..|.|:.||..:::|||:|.|..:|:.:
  Fly   724 RGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDL 788

Mouse   796 KEKWWR--GSGCPEEENKEASA-LGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRS 857
            |:|||:  .:.|.||.:.:|:. :..:::.|||..|.||::::.|:.:.||:..:::.|..|:.:
  Fly   789 KQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLT 853

Mouse   858 FCSTVADEIRFSL 870
            |......||||.|
  Fly   854 FKDAFKKEIRFVL 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik3	NP_001074566.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	113/423 (27%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	135/376 (36%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	113/425 (27%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	12/109 (11%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	134/371 (36%)
		Lig_chan	554..828	CDD:278489	96/273 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850