DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNRF4 and gzl

DIOPT Version :9

Sequence 1:	NP_859061.3	Gene:	ZNRF4 / 148066	HGNCID:	17726	Length:	429	Species:	Homo sapiens
Sequence 2:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	349	Identity:	101/349 - (28%)
Similarity:	160/349 - (45%)	Gaps:	57/349 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    77 GRALVAVKALLVLSLLQVPAQAVVRAVLEDNSSSVDFADLPALFGVPLAPEGIRGYLMEV-KPAN 140
            |..||..:|.||...:.|..:|..:.:.|       |.||||.||..|...|::.|::.. :|..
  Fly    13 GLCLVCHEATLVGGHVLVYRKATSQLIEE-------FNDLPAQFGPNLPSNGLKVYVVPARRPYY 70

Human   141 ACHPIEAPRLGNRSLGA--IVLIRRYDCTFDLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDL 203
            .|..::.|........|  :.|:.|.:|.|:.|:..||.|.:.|.||:|...|||..|:  .|::
  Fly    71 GCDSLDRPPHLKYPPSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDDLEQMS--AENI 133

Human   204 RGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDDPPCHDLGCHPVLTVSWVLG-CTLALVVS 267
            .| |.||||||.....:.|....    :...:|:.:|....::....:|..|.::| |.:.:|:.
  Fly   134 TG-IRIPSVFVGHTTGKALATYF----TTEVVLIINDELPFNINTQLILPFSILIGMCFIIMVIY 193

Human   268 AFFVLNHLWLWAQACCSHRRPVK-----TSTCQKAQVRTFTWHN-----DLCAICLDEYEEGDQL 322
            ..:          .|...:|.::     .|..:|..|..:|.:|     |.|.|||:::.|.|:|
  Fly   194 MIY----------KCIREQRRLRRHRLPKSMLKKLPVLRYTKNNANNKYDTCVICLEDFIEDDKL 248

Human   323 KILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSV---------AATEDSFDSTTYSFRDEDPSLPG 378
            ::|||||.||..|||||.:: .||.||:||:.|         .:.:.|.|:.|.:..|..|.|.
  Fly   249 RVLPCSHPYHTHCIDPWLTE-NRRVCPICKRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQ- 311

Human   379 HRPPIWAIQVQLRSRRLELLGRAS 402
                    |.|...|::..:..||
  Fly   312 --------QQQSNGRQVGQVSSAS 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNRF4	NP_859061.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..67
		PA_C_RZF_like	86..244	CDD:239038	47/160 (29%)
		zf-RING_2	307..352	CDD:290367	24/44 (55%)
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	50/170 (29%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	24/44 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8867
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41191
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.780