Protein Alignment ZNRF4 and C18B12.4

DIOPT Version :9

• Sequence 1: NP_859061.3
• Gene: ZNRF4 / 148066
• HGNCID: 17726
• Length: 429
• Species: Homo sapiens
• Sequence 2: NP_510498.1
• Gene: C18B12.4 / 181600
• WormBaseID: WBGene00007666
• Length: 456
• Species: Caenorhabditis elegans
• Alignment Length: 367
• Identity: 90/367 - (24%)
• Similarity: 149/367 - (40%)
• Gaps: 73/367 - (19%)

Human    75 RPGRALVAVKALLVL-SLLQVPAQAVV---------------RAVLEDNSSSVDFADLPALFGVP 123
            :.||.:|....|||| .:.|..||.||               :.:.:..:..:|.:|.
 Worm     3 KKGRNVVQSVGLLVLFGIYQCNAQYVVDVMRMTSFGEEELVHKCLAKGGNFGMDVSDF------- 60

Human   124 LAPEGIRGYLMEVKPANACHPIE-APRLGNRSLGAIVLIRR----YDCTFDLKVLNAQRA--GFE 181
            :..|...|..:.|:|.:||.|:. |.....|.......:.|    :.|.|..:....|.:  .|.
 Worm    61 IISEENLGCGVGVEPVDACGPVRIAQNHTTRCHNLFAFVSRSNISHPCKFSHQAFMVQNSTYPFR 125

Human   182 AAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDDPPCHDL 246
            ..|.:|....:.:||...  :||.::.||.:.:|.|..:::..... :.:.:.|.:..||..::|
 Worm   126 LVIFYNYPGQEPISMEGT--ELRDKVNIPVLMISHACKEEIAKKFS-DTAGYRLRVRIDPGYYEL 187

Human   247 GCH--PVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHR----RPVKTSTCQKAQVRTFTWH 305
            ..:  |.|.|  ::.|         |.|..:.|..:.|...|    |.:.....:|..|:.:...
 Worm   188 FRYLIPFLVV--IVFC---------FALFLITLCVRGCVERRKLNKRRLSKRNLKKIPVKKYRLG 241

Human   306 N--DLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSVAATEDSFDSTT-- 366
            :  |.|||||:.:..|::|:.|||.|.:||.|||.|.:|. |:.||:||:.:....||..||.
 Worm   242 DDPDTCAICLESFASGEKLRHLPCRHVFHCNCIDVWLTQT-RKICPLCKRKIGTDSDSECSTNDL 305

Human   367 -------------YSFRD-----EDPSLPGHRPPIWAIQVQL 390
                         |:..|     |.|...|....:|:.|..|
 Worm   306 ASTSQGPNDATALYNNADNQSGFELPVPQGQMVDLWSSQEAL 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNRF4	NP_859061.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..67
		PA_C_RZF_like	86..244	CDD:239038	38/180 (21%)
		zf-RING_2	307..352	CDD:290367	22/44 (50%)
C18B12.4	NP_510498.1	PA	<74..176	CDD:333703	21/104 (20%)
		HRD1	<223..>335	CDD:227568	35/112 (31%)
		RING-H2_RNF103	246..291	CDD:319387	23/45 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I6450
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I3469
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm15079
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.820