DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNRF4 and rnf128

DIOPT Version :9

Sequence 1:	NP_859061.3	Gene:	ZNRF4 / 148066	HGNCID:	17726	Length:	429	Species:	Homo sapiens
Sequence 2:	XP_012824820.2	Gene:	rnf128 / 100145171	XenbaseID:	XB-GENE-877067	Length:	403	Species:	Xenopus tropicalis

Alignment Length:	407	Identity:	92/407 - (22%)
Similarity:	156/407 - (38%)	Gaps:	99/407 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    74 PRPGRALVAVKALLVLSLLQVPAQAVVRA-----VLEDNSSSVDFADLPALFGVPLAPEGIRGYL 133
            ||.......:.|||:|:|....|..:..|     .:.||.:..:..:: .:||.....|...|.:
Frog     7 PRQFLPFPCLPALLLLNLSLTGADTLWTANVNYSYVYDNRTYGEEGEI-GVFGQDSPIERAAGLV 70

Human   134 MEVKPA---NACHP---IEAPRLGNRSLGAIVLIRRYDCTFDLKVLNAQRAGFEAAIVHNVHSD- 191
            :..|..   .||..   ...|...|....|::| |...|||..|:..|...|..|.:|:|...|
Frog    71 VLPKSERTFTACKDNTNFSVPHNWNGPWIALIL-RGGGCTFTEKINRAAERGARAVVVYNNGMDN 134

Human   192 DLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDDPPCHDLGCHPVLTV-- 254
            ::..|:|  ...:..:||  :..:...::.:.||.|                   |...::.:
Frog   135 EVFEMSH--PGTKDTVAI--MIGNIKGNEIVEVIKG-------------------GMQVMMVIEV 176

Human   255 -----SWVLGCTLALVVSAFFVLN------------HLWLWAQACCSHRRPVKTSTCQ---KAQV 299
                 ||:...::..|..:||::.            ..|...:|.....:.:|....:   |.|:
Frog   177 GRKHGSWINHYSIFFVSVSFFIVTAATVGYFIFYSARRWRLTRAQNKKMKQLKAEAKKAIGKLQL 241

Human   300 RTFTW-------HNDLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCK----Q 353
            ||...       ..|.||:|::.|:..|.::||.|:|.:|..|||||..:  .|:||:||    :
Frog   242 RTIKQGDKVLGPDGDSCAVCIEPYKPSDVVRILTCNHFFHKNCIDPWLLE--HRTCPMCKCDILK 304

Human   354 SVAATEDSFDSTTYSFRDEDPSLPG--HRPPIWAIQVQLRSRRLELLGRAS-------------- 402
            |:...||..::|:.:.    ||:..  .|..:..|:.:.|| .:...|.||
Frog   305 SLGIAEDEEETTSAAI----PSVSSELQRSTVQTIEEENRS-EMASSGYASVRGGDEPVDEGQHI 364

Human   403 ------PHCHCSTTSLE 413
                  .|...|.||:|
Frog   365 YENTELVHNEASATSIE 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNRF4	NP_859061.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..67
		PA_C_RZF_like	86..244	CDD:239038	37/169 (22%)
		zf-RING_2	307..352	CDD:290367	19/44 (43%)
rnf128	XP_012824820.2	PA_GRAIL_like	38..174	CDD:239037	32/160 (20%)
		COG5540	<208..302	CDD:227827	28/95 (29%)
		RING-H2_RNF128_like	256..304	CDD:319716	21/49 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920