DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik1 and GluRIIC

DIOPT Version :9

Sequence 1:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	930	Identity:	275/930 - (29%)
Similarity:	460/930 - (49%)	Gaps:	121/930 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 LWTR----DTSWTLLYFLCYILPQTSPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLM 72
            :|.|    ...|: .:|:|    ::..|.:.||..|...|.|    .|..|...|.:||...:
  Fly     1 MWQRILLLGCMWS-AFFMC----RSRGQQINIGAFFYDDELE----LEKEFMTVVNAINGPES-- 54

Mouse    73 PNTTLTYD-IQRINLFD-SFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRW 135
            ..|...|. |:|:...| |......|||.:..||||:||||..::...|..:||:..:|||:...
  Fly    55 EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDI 119

Mouse   136 KHPSVD----NRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVY--EDSTGLIRLQELIKAPS 194
            ....:.    |..: .:||||..|.:|:|..|:|..:.|:..|:||  :|:....|||:|::...
  Fly   120 SDEGIQAEKPNHQM-TLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLRE 183

Mouse   195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTT 259
            .:|..:::|:... :.|.:.:.|.::  .|..|:.||......|:|......|:..:|.|.|.|.
  Fly   184 VHNDVVRVRKFHK-DDDFRVMWKSIR--GERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTN 245

Mouse   260 LDLF-------ALDLELYRYSGVNMTGFRLL-NIDNPHVS----------SIIEKWSMERLQAPP 306
            |:.:       |.|.|.:   .||:|..||| |.|.|..|          :|:.:.|     .||
  Fly   246 LETYTDHLEELAADNETF---AVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESS-----DPP 302

Mouse   307 RPETGLLDGVMTTEAALMYDAVYMVAIASHRAS-----QLTVSSLQC----HRHKPWRLGPRFMN 362
            |          |....|::||:.:.|.:...||     ::.|..:.|    ...:.|.:|.....
  Fly   303 R----------TLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMGRYLAR 357

Mouse   363 LIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIG--IWNSNS 425
            |:|     |.:|   .|.|     :|...|:...|:| ::.:..:  .:|.....||  ||:...
  Fly   358 LMK-----GTSG---VNNT-----NFRTSILQFDEDG-QRITFNI--EVYDPLDGIGIAIWDPRG 406

Mouse   426 GLNMTDGNRDRSNNITDSLANRTLI--VTTILEEPYVMYRKSDKP--LYGNDRFEGYCLDLLKEL 486
            .:...:         .|..|.:.:|  |.|.:..||..|.::.:.  |.||..::||.:||:..:
  Fly   407 QITQLN---------VDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAI 462

Mouse   487 SNILGFLYDVKLVPDGKYG-AQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMT 550
            :..:||.|....|.|.:|| ...:..:|||::.|:|::.|.:.:..||||..|:..:||:.|||.
  Fly   463 ARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQ 527

Mouse   551 LGISIL-YRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDS 614
            ||:||| |:.|: ....:.::|.|...::|:::|::...::.:..::||.:..:|.||||||.|.
  Fly   528 LGVSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDP 591

Mouse   615 DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERM 679
            :|:||.:.:.|:.|..|.::|..|.:::|::...|:....||.|.:||.:|||||||||||..:|
  Fly   592 EVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKM 656

Mouse   680 ESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVL 744
            |..|.:..||:.|.|:::|.:..|||......|..:.|...:..|::...||..|::.||:.||.
  Fly   657 EGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVR 721

Mouse   745 TT--DYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLH 807
            ..  ||..|||:|::||..::||:|..:|.....|.|.:..|.|:.||..:::|||:|.|.|:|:
  Fly   722 KNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELY 786

Mouse   808 MMKEKWWR--GNGCPEEDSKEASA-LGVENIGGIFIVLAAGLVLSVFVAIGEF-IYKSRKNNDIE 868
            .:|:|||:  ...|.||...:|:. :..|.:.|||..|.||::::..:.|.|| :|       ::
  Fly   787 DLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVY-------VQ 844

Mouse   869 QKGKSSRLRF--YFRNKVRF 886
            |.....||.|  .|:.::||
  Fly   845 QVALEERLTFKDAFKKEIRF 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	112/429 (26%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	132/376 (35%)
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	112/421 (27%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	21/103 (20%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	131/371 (35%)
		Lig_chan	554..828	CDD:278489	98/273 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846254
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860