DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grid2 and GluRIIC

DIOPT Version :9

Sequence 1:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	972	Identity:	245/972 - (25%)
Similarity:	413/972 - (42%)	Gaps:	184/972 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 LLFLSFCWSRTWDLATADSIIHIGAIFDESAKKDDEVFRTAVGDLN--QNEEILQTEKITFSVTF 69
            :|.|...||..:...:....|:|||.|.:...:.::.|.|.|..:|  ::|:.::...:...:..
  Fly     5 ILLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKP 69

Mouse    70 VDGNNPFQAVQEACELMNQGILAL----------VSSIGCTSAGSLQSLADAMHIPHLFIQRSTA 124
            .||:...|  :.||:|::.|:.|:          :.::.|.|.|          |||:....|..
  Fly    70 EDGSVTMQ--EHACDLIDNGVAAIFGPSSKAASDIVALVCNSTG----------IPHIEFDISDE 122

Mouse   125 GTPRSGCGLTRSNRNDDYTLSVRP-PVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKV 188
                   |:.....|...||::.| ...|::....:|..:.|:||.|.||:: |.|......|.:
  Fly   123 -------GIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDAD-DARAAARLQDLL 179

Mouse   189 SQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTL---------RRAILVMNPATAKSFIS 244
            .       |::|.|          |.:|:.:.::..|..         ||.:|...|......::
  Fly   180 Q-------LREVHN----------DVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLN 227

Mouse   245 EVVETNLVAFDCHWIIINEEINDVDVQEL--------VRRSIGRLTIIRQTFPVPQNISQRCFRG 301
            ...|..|.....|..:.|.|.....::||        |..:..||.:  ...|.|.::.......
  Fly   228 SSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLV--NPDPPPYSLPYGYVTQ 290

Mouse   302 NHRISSSLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKK---LEDRKWHSMASLSCIRKNSKPW 363
            ...|.....||......::      |:|.:.|.|.::...   ..||......:........:.|
  Fly   291 RDNIVYESSDPPRTLIHDL------IHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTW 349

Mouse   364 QGGRSMLETIK-KGGVNGL---TGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNP--- 421
            ..||.:...:| ..|||..   |..|:|.|:|.....:.|:    |....|.|:   ..|:|
  Fly   350 AMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEV----YDPLDGIGI---AIWDPRGQ 407

Mouse   422 VTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSE-----NVLGKPKKYQGFSIDVLDALSNY 481
            :|.||   .|.|.:..|   :.||.|.:..|:...:|     |:.|. ..|||:::|::||::.:
  Fly   408 ITQLN---VDVKAQKKM---IYRVATRIGPPYFSYNETARELNLTGN-ALYQGYAVDLIDAIARH 465

Mouse   482 LGFNYEIYVAPDHKYGS-PQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSV 545
            :||.|......|.:||. .:|...|||::||::...|.:||..||||..|:..||||..:|...|
  Fly   466 VGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGV 530

Mouse   546 GVLLRRA---EKTVDMFACLAPFDLSLWACIAGTVLLVGLL------VYLLNWLNP------PRL 595
            .:|..::   |||:|  |.||||...:|..|..:|.::..|      :..::|.||      |.:
  Fly   531 SILAYKSPHVEKTLD--AYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEV 593

Mouse   596 QMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITR 660
            .....   .::|:.|....|.:..|.::...:...||....||:||:|:.:|||||||||||.::
  Fly   594 LENQW---RIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSK 655

Mouse   661 IESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGS---ENNV 722
            :|.||.:|:|||.|..:.:||:...:.|      .|.....:::|...:.::|..:.|   ::|:
  Fly   656 MEGSIANLKDLSAQKKVKFGTIYGGSTY------NLLADSNETVYRLAFNLMNNDDPSAYTKDNL 714

Mouse   723 LESQAGIQKVK--YGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFS 785
                .|:.:|:  .|:|.|:.:...|||  ..:.:|...:||....::.|.||:..|:.||...|
  Fly   715 ----EGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLS 773

Mouse   786 QRILELQQSGDMDILKHKWWPK-NGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIA 849
            ..||:|.:.|::..||.|||.. |..|......||...   :..:.|.|:|..|.|||:::.||.
  Fly   774 VAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPD---MTFEELRGIFYTLYAGILIAFLIG 835

Mouse   850 VLE--------------TW--------------WSRRK----GSRV------PSKEDDKEID 873
            :.|              |:              |:.||    |:.:      |.:..||.:|
  Fly   836 ITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSLD 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		70/353 (20%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	92/440 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	121/391 (31%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	88/429 (21%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	14/89 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	121/388 (31%)
		Lig_chan	554..828	CDD:278489	82/291 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840