DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grid2 and Ir8a

DIOPT Version :9

Sequence 1:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	817	Identity:	192/817 - (23%)
Similarity:	337/817 - (41%)	Gaps:	189/817 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse   181 IQEFLDKVSQQG----MDVALQKVENNINKMITTLFDTMRIEELNR-----YRDTLRR------A 230
            :|.|.:.:|..|    :|:.....|...|.:.:.....:|:|.:.|     :.|.:|:      |
  Fly    70 MQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVA 134

Mouse   231 ILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNIS 295
            ::.||...|    .|.::..||.:....:|::....|.....|.|        ||...|.|..|:
  Fly   135 MVFMNARDA----VEAMQQMLVGYPFRTLIMDASQTDPGQHFLER--------IRSLRPAPTYIA 187

Mouse   296 -----------------------------------QRCFRGNHRISSSLC-----DPKDPFAQNM 320
                                               .|.|:  :|..:.||     :|: ...::|
  Fly   188 LFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRVFK--YRRQAELCTRFTLNPR-AICRSM 249

Mouse   321 EISNLY-----------IYDTVLLLANAFH-------------------------KKLEDRKWHS 349
            .:.:||           :.:.:..|.||..                         .:.:|..|..
  Fly   250 PMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLD 314

Mouse   350 MASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVR 414
            |...|.....:.|....:...::    .|.|||    |..|          :...|.........
  Fly   315 MVHWSNFLAYAPPLPHIQDQFQS----PVPGLT----FAVN----------ISAGYYSSEHEAKT 361

Mouse   415 KLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPF-VMVSENVLGKPKK-------YQGFS 471
            .|..|:.|..:.  |.::.:....|  ..|:.|....|: .:..|...|:..:       ::|:.
  Fly   362 DLAAWSSVGEMR--LLNETISPARR--FFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYC 422

Mouse   472 IDVLDALSNYLGFNYEIYVAPDHKY-GSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVD 535
            ||.:..||..|.|.:|| |||:..: |...|.|.|:|:||:||....|..|:||.:..:||.|:|
  Fly   423 IDFIIRLSQKLNFEFEI-VAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVID 486

Mouse   536 FTTRYMDYS-VGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMG- 598
            |...|.:.: :.:.:|:..:...:|..:....|.:|..|...::...::::.::..:|...:..
  Fly   487 FLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNR 551

Mouse   599 -----SMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTI 658
                 :....||..|.||...||..|||......::.||::.|:|||.:::::::|||||||||:
  Fly   552 QAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTV 616

Mouse   659 TRIESSIQSLQDLSKQTDIPYGTVLDSAVYQH-VRMKGLNPFERDSMYSQMWR--MINRSN---- 716
            .|:::.:|||:.|::|:.|.|..|.||..:|: |.||    |..|::| :||:  .:|.|.
  Fly   617 ERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMK----FAEDTLY-RMWKELALNASKDFKK 676

Mouse   717 -------------------GSENNVLESQAGIQKV---KYGNYAFVWDAAVLEYVAINDPDCSFY 759
                               .|...|.:::.|...|   :..:|||:.|:|.::|....  :|:..
  Fly   677 FRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITR--NCNLT 739

Mouse   760 TVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNG--QCDLYSSVDAKQK 822
            .||...|::.|.:|:|.||...|..|..|||||:....:.||.|:|.::.  .|.|  |.|  |:
  Fly   740 EVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPL--SED--QE 800

Mouse   823 GGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRK 859
            |  :.::||.|||.....|:||:.:...:|..:.::|
  Fly   801 G--ITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKK 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		40/254 (16%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	55/338 (16%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	118/410 (29%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	119/412 (29%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	91/310 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810