Protein Alignment Grid1 and KaiR1D

DIOPT Version :10

• Sequence 1: NP_032192.2
• Gene: Grid1 / 14803
• MGIID: 95812
• Length: 1009
• Species: Mus musculus
• Sequence 2: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Alignment Length: 919
• Identity: 275/919 - (29%)
• Similarity: 446/919 - (48%)
• Gaps: 110/919 - (11%)

Mouse     4 LTLWLLPWICQCVTVRA-DSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVI 67
            |.|.||..|..|...:: ..||.||.:|.......:..|:.||..::.:..||...|:...|:.|
  Fly     9 LPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERI 73

Mouse    68 EANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNP 132
            ...:.|.|.:..|.|:..|:.|:.......:|:.:||:.|.|.|||| ..|......|.:|.:|.
  Fly    74 SPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL-ENRWDYRLRRESCLVNL 137

Mouse   133 SPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKV 197
            .|.          |..|:...:.:|....|:.|.:.|::...|..||..|.
  Fly   138 YPH----------PNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLK-------------- 178

Mouse   198 DKNISHVFTSL-FTTMKTEELNRYRDTLRR--------AILLLSPQGAHSFINEAVETNLASKDS 253
                :|..|.. .|..:..:...||..|::        .:|..|.:..|..:.:|.:..:.| |.
  Fly   179 ----AHGMTPFPITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMS-DY 238

Mouse   254 HWVFVNEEISDPEILDLVHSALG--RMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQML 316
            |...|..  .|...::|.....|  .:|..|.|      |:|.:.:..|..|:   .::|.|:..
  Fly   239 HSYLVTS--LDLHTVNLDEFRYGGTNITGFRLI------NEKIVSDVVRQWSI---DEKGLLRSA 292

Mouse   317 QISNL-----YLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITG 376
            .::.:     .:||:|.:.|.|.| .|:..:...:..::|..:||  |..|.|:::.:|...:.|
  Fly   293 NLTTVRSETALMYDAVHLFAKALH-DLDTSQQIDIHPISCDGQST--WQHGFSLINYMKIVEMKG 354

Mouse   377 LTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDS--EKGLN----GSLQERPMGSRLQ 435
            ||.|::|...........:|:..|.:     .:||:.||:|  ..|:|    .|.:::.:.:.|:
  Fly   355 LTNVIKFDHQGFRTDFMLDIVELTPA-----GIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLK 414

Mouse   436 GLTLKVVTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHN 498
            ..||.|.|:|..|:.|..|:.  |....:::|:::|::..::|:|||.|:|...|||.||.....
  Fly   415 NKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKL 479

Mouse   499 T-SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKP-EEKISIFSLFAPF 561
            | .|||||.||:.:||||||:.:|||.|||..|||:..:|:..|.||.:|| ::..::||..:|.
  Fly   480 TGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPL 544

Mouse   562 DFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQ---PRPSASATLHSAIWIVYGAFVQQGGES 623
            ...||..:|.|...|.||:|:|.:.......:.|.   .:..:..||.:.:|...|:.:|||.:.
  Fly   545 SLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDF 609

Mouse   624 SVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYGTVRDSAVY 688
            ...:::.|:|.|.||.||||:.|||||||||||||.|||:||.:.:||:||..:.||.::..:..
  Fly   610 LPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTA 674

Mouse   689 EYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGI-RKAK-KGNYAFLWDVAVVEYAAL 751
            .:||.      .:.||:..:|..:.....:....|| .||: |.|| ||:||||.:...:||  :
  Fly   675 AFFRD------SKISTYQRMWSFMESARPSVFTASN-GEGVERVAKGKGSYAFLMESTSIEY--V 730

Mouse   752 TDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHT---GRCDL 813
            |:.:|.:|.:|..:.:|.||||....||||...:..||:||:.|.|.:||.|||...   |:|.:
  Fly   731 TERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRV 795

Mouse   814 -TSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVH 877
             ||.||  :....|.|.:..|||.:|..|:.:||::|..|..|.|.:.              .|.
  Fly   796 ETSKSS--SAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKV--------------AVE 844

Mouse   878 RRINSLMDE 886
            .|::::::|
  Fly   845 ERLSAILNE 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269|PubMed:27418511	21..436		99/436 (23%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	95/421 (23%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	147/378 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	95/417 (23%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	147/378 (39%)