Protein Alignment Grid1 and Ir8a

DIOPT Version :9

• Sequence 1: NP_032192.2
• Gene: Grid1 / 14803
• MGIID: 95812
• Length: 1009
• Species: Mus musculus
• Sequence 2: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Alignment Length: 1024
• Identity: 224/1024 - (21%)
• Similarity: 377/1024 - (36%)
• Gaps: 318/1024 - (31%)

Mouse   142 ASRPPVRLNDVMLRLVTE---LRWQKF----------------VMFYDSEYDI------------ 175
            |.|..|:::|..|.|...   |..|:|                ...::..|::
  Fly    47 ALRLDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLE 111

Mouse   176 RGLQSFLDQASRLGLDVSLQKVDKNISHVF--------------------TSLFTTMKTEE---- 216
            |.::.|||...    |...||...|::.||                    |.:....:|:.
  Fly   112 RIMRPFLDMFG----DFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHF 172

Mouse   217 LNRYRDTLRRA---ILLLSPQGAHSFINEAVE-TNLASKDSHWVFVNEEISD------------- 264
            |.|.| :||.|   |.|.:...|.:.|.|.|: .:|..:...|.||..:..|
  Fly   173 LERIR-SLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRVFKYRRQAELCT 236

Mouse   265 ---------------PEI-----LDLVHSALGRMTVVRQIFPSAKDN--------QKCMRNNHRI 301
                           |::     ..:..:.|  :.|:|.:..:|:.:        |.|  |....
  Fly   237 RFTLNPRAICRSMPMPDLYCGSGFTMQRAML--LNVLRSLINAAQVSPGYPLAIYQDC--NATAS 297

Mouse   302 SSLLCDPQE----GYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGG 362
            ||.:.||.|    .:|.|:..||...|...|       ..::|:           .:|..|   |
  Fly   298 SSEVSDPLEKDDYNWLDMVHWSNFLAYAPPL-------PHIQDQ-----------FQSPVP---G 341

Mouse   363 RSMLDTIKKGHIT------------GLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATW 415
            .:....|..|:.:            ...|.|....::.:|..:|..:||..|          ..|
  Fly   342 LTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAES----------IPW 396

Mouse   416 D---SEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKA 477
            .   .|:|....:::|      .||.:                       ::|:.||.:..|::.
  Fly   397 SYLRREEGTGELIRDR------SGLPI-----------------------WEGYCIDFIIRLSQK 432

Mouse   478 LGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYS-V 541
            |.|::||.....|..|.......|:|::|:|:....|.||:|:.:..|||.|:||...|.:.: :
  Fly   433 LNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGI 497

Mouse   542 GILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRPSA--SAT 604
            .|.|:||..:.|:|.........||..|.||:....::|:.:::.....|::..|..|.|  ..|
  Fly   498 SIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYACREFT 562

Mouse   605 LHSAIWIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQ 669
            |..:.|....:|..|||..:..:::.|:::.::|||.:::.:::||||||||||.||..|:::.:
  Fly   563 LRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLE 627

Mouse   670 DLSKQLEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGAD--------------- 719
            .|::|..::|..|:||..::||    .|....:.|...:|:.::.|...|
  Fly   628 QLARQSRINYTVVKDSDTHQYF----VNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQY 688

Mouse   720 ---NCVSNPSEGIRKAKKG----------NYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYG 771
               ....|.|:.:..||:|          :|||:.|.|.::|....  :|::|.:|...:.:.|.
  Fly   689 GHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITR--NCNLTEVGEVFAEQPYA 751

Mouse   772 IALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTG--RCDLTSHSSTQTEGKSLKLHSFAGV 834
            :|:|.||...|..|..|||||.....:.||.|:|..:.  .|.|    |...||  :.|.|..||
  Fly   752 VAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPL----SEDQEG--ITLESLGGV 810

Mouse   835 FCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRINSLMDEDIAHKQISPASIE 899
            |.....||:||.:...:|:.:...:
  Fly   811 FIATLFGLVLAMMTLGMEVLYYKKK---------------------------------------- 835

Mouse   900 LSALEMGGLAPSQALEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSAT---- 960
                                 ||. |.::...|...|.|     |.|.||..| |.::|.|
  Fly   836 ---------------------QNA-LEITQVRPVNDSSG-----SGGNSSTAP-PTATSTTKQAW 872

Mouse   961 -MPSIQCKHRSPNGGLFRQSPVKTPIPMSFQPVP--GGVLPEALDTSHG 1006
             :|.::.:          :.|.|...|.||:...  |..||..:....|
  Fly   873 HIPVLEAE----------EKPAKVSPPPSFETATFRGKKLPARITLGDG 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269|PubMed:27418511	21..436		75/412 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	74/399 (19%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	109/400 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960		10/28 (36%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	117/447 (26%)
		Lig_chan	520..818	CDD:278489	87/309 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810