DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gria4 and Ir64a

DIOPT Version :9

Sequence 1:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus
Sequence 2:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	696	Identity:	127/696 - (18%)
Similarity:	225/696 - (32%)	Gaps:	213/696 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse   291 ETPPKYTSALTYDGVLVMAETF----RSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQ 351
            |.||......|.|..|...|:|    ......::.:::|       .:.||.:        ||..
  Fly   214 EEPPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKR-------MSEAAHY--------TLFD 263

Mouse   352 VRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAAIENR- 415
            |...||       :||..||.|            ::|.:...:.:.|    .|....|:.:..|
  Fly   264 VWNPGL-------NYGGHVNLT------------EIGSFTPTEGIQL----HTWFRTTSTVRRRM 305

Mouse   416 ---------TVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIA------ 465
                     .||||....:..:||...|.|....|....:..:|...:.......:.::
  Fly   306 DMQHARVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWG 370

Mouse   466 IVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 530
            .|.:|::          :||:|.|:..:.:|..||:...|.|.:.||.:....|.....:.:.|:
  Fly   371 YVKNGRF----------DGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPR 425

Mouse   531 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV-LFLVSRFSPYEW--------------------- 573
            .::.....||.|...::|:.||    |..|: :|::...:..||
  Fly   426 STQKDRIVFLQPFTNDVWILIV----GCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRH 486

Mouse   574 --------------------------------HTEEPEDG----------------------KEG 584
                                            ..||.||.                      ::.
  Fly   487 HYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKA 551

Mouse   585 PSDQPPNEFGIF-NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 648
            ...:.|...|:| .|:.|.:|...|||...|...:|||.:......|:..|...|:|::...|.:
  Fly   552 KQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLM 616

Mouse   649 ERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVA 713
            |: ...|::..||. .:.:..|..|....:::|..:|..|..:::....::.|     ||.|..|
  Fly   617 EK-PKTIKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVP-----TTKENEA 674

Mouse   714 ---------RVRKSKGK-----------------------------------FAFLLE-----ST 729
                     .|.....|                                   |||.::     ..
  Fly   675 DEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKI 739

Mouse   730 MNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGE 794
            :.|...::..||..:|......|...: ..|.|.:|..::..:.:::|.|:|....|.|...|..
  Fly   740 IAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPP 803

Mouse   795 CGPKDSGSKDKTSAL--SLSNVAGVFYILVGGLGLAMLVALIEFCY 838
            |     ..|.:||.|  .:..|:....||:....:.:::...|..|
  Fly   804 C-----VKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILY 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	23/112 (21%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	92/522 (18%)
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	24/127 (19%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	56/277 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840