Protein Alignment Gria4 and Ir64a

DIOPT Version :10

• Sequence 1: XP_006509904.1
• Gene: Gria4 / 14802
• MGIID: 95811
• Length: 912
• Species: Mus musculus
• Sequence 2: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Alignment Length: 696
• Identity: 127/696 - (18%)
• Similarity: 225/696 - (32%)
• Gaps: 213/696 - (30%)

Mouse   291 ETPPKYTSALTYDGVLVMAETF----RSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQ 351
            |.||......|.|..|...|:|    ......::.:::|       .:.||.:        ||..
  Fly   214 EEPPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKR-------MSEAAHY--------TLFD 263

Mouse   352 VRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAAIENR- 415
            |...||       :||..||.|            ::|.:...:.:.|    .|....|:.:..|
  Fly   264 VWNPGL-------NYGGHVNLT------------EIGSFTPTEGIQL----HTWFRTTSTVRRRM 305

Mouse   416 ---------TVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIA------ 465
                     .||||....:..:||...|.|....|....:..:|...:.......:.::
  Fly   306 DMQHARVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWG 370

Mouse   466 IVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 530
            .|.:|::          :||:|.|:..:.:|..||:...|.|.:.||.:....|.....:.:.|:
  Fly   371 YVKNGRF----------DGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPR 425

Mouse   531 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV-LFLVSRFSPYEW--------------------- 573
            .::.....||.|...::|:.||    |..|: :|::...:..||
  Fly   426 STQKDRIVFLQPFTNDVWILIV----GCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRH 486

Mouse   574 --------------------------------HTEEPEDG----------------------KEG 584
                                            ..||.||.                      ::.
  Fly   487 HYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKA 551

Mouse   585 PSDQPPNEFGIF-NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 648
            ...:.|...|:| .|:.|.:|...|||...|...:|||.:......|:..|...|:|::...|.:
  Fly   552 KQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLM 616

Mouse   649 ERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVA 713
            |: ...|::..||. .:.:..|..|....:::|..:|..|..:::....::.|     ||.|..|
  Fly   617 EK-PKTIKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVP-----TTKENEA 674

Mouse   714 ---------RVRKSKGK-----------------------------------FAFLLE-----ST 729
                     .|.....|                                   |||.::     ..
  Fly   675 DEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKI 739

Mouse   730 MNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGE 794
            :.|...::..||..:|......|...: ..|.|.:|..::..:.:::|.|:|....|.|...|..
  Fly   740 IAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPP 803

Mouse   795 CGPKDSGSKDKTSAL--SLSNVAGVFYILVGGLGLAMLVALIEFCY 838
            |     ..|.:||.|  .:..|:....||:....:.:::...|..|
  Fly   804 C-----VKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILY 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	23/112 (21%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	92/522 (18%)
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	24/127 (19%)
		Lig_chan	563..828	CDD:459656	56/277 (20%)