DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gria4 and Ir8a

DIOPT Version :9

Sequence 1:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	868	Identity:	203/868 - (23%)
Similarity:	347/868 - (39%)	Gaps:	228/868 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse   191 DVSYRQLLEELDRRQEKKFVIDCEIE-------------RLQNILEQIVSVGKHV---------- 232
            |.....:|:|||..:     :|.:::             .:|...|.:.:||...
  Fly    35 DTDIAMVLKELDALR-----LDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWE 94

Mouse   233 KGYHYIIANLGFKDISLERFIHGGANVTGFQLVDF-------NTPMV-TKLMDRWKKLDQR--EY 287
            :||: ::.:||...:.|||.:....::.|    ||       |..|| ....|..:.:.|.  .|
  Fly    95 EGYN-LVRSLGIGYVRLERIMRPFLDMFG----DFMRQKRANNVAMVFMNARDAVEAMQQMLVGY 154

Mouse   288 P-------GSETPP---------KYTSALTYDGVLVMAETFRSL--RRQKIDISR---------- 324
            |       .|:|.|         ....|.||..:...|.....:  :.||.|:.:
  Fly   155 PFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFL 219

Mouse   325 ---------RGNAGDC---LANPAA-----PW-----GQGIDMERTLKQVRIQGLTGNVQ----- 362
                     |..|..|   ..||.|     |.     |.|..|:|.:....::.|....|
  Fly   220 DTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGY 284

Mouse   363 ------------------------------------FDHYGRRVNYTMDVFELKSTGPR-----K 386
                                                |..|...:.:..|.|:....|..     .
  Fly   285 PLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNIS 349

Mouse   387 VGY-------------WNDMDKLVLIQDAPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFE 438
            .||             |:.:.::.|:       |:|.:...|...:.|....|:...::.....|
  Fly   350 AGYYSSEHEAKTDLAAWSSVGEMRLL-------NETISPARRFFRIGTAESIPWSYLRREEGTGE 407

Mouse   439 ------GNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIA 497
                  |...:||||:|....:::.:..:::|.....|..|..: :...|:|:||:||.|:.:.|
  Fly   408 LIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGVVGDLVRGETDFA 471

Mouse   498 IAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV 561
            ||.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:.||.|.:|.:::
  Fly   472 IAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIM 535

Mouse   562 LFLVSRFSPYEWHTEEPEDGKEGPSDQP--PNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 624
            ::.:.::|||        ..:......|  ..||.:..|.||:|.:|..||...:|:::|||::.
  Fly   536 IWFMDKYSPY--------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLV 592

Mouse   625 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA-- 687
            ..:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..:....|.::|...|.|
  Fly   593 AAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAED 657

Mouse   688 -VYE----------------KMWTY------------MRSAEPSVFTRTTAEGVARV-RKSKGKF 722
             :|.                ::|.|            :.|::|   .....||.|.| ......:
  Fly   658 TLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADY 719

Mouse   723 AFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNK 787
            ||:.:|...:| |..:.|:..:||.....:.|.||..:||.|...::.|:|:|.:....::||.|
  Fly   720 AFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAK 783

Mouse   788 WWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIE-FCYKSRAEAKRMKVAK 851
            :|.....  |....|:|: ..::|.::.|||...:.||.|||:...:| ..||.:..|..:...:
  Fly   784 YWNQSNL--PNCPLSEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALEITQVR 845

Mouse   852 ----------SAQTFNPTSSQNT 864
                      ::.|..||::..|
  Fly   846 PVNDSSGSGGNSSTAPPTATSTT 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	59/350 (17%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	122/421 (29%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	121/416 (29%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	87/312 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910