DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gria2 and KaiR1D

DIOPT Version :9

Sequence 1:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	859	Identity:	336/859 - (39%)
Similarity:	506/859 - (58%)	Gaps:	76/859 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse    27 IQIGGLFPRGADQEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFAVTNAFCSQFSRGVY 86
            |:|||||....|.:..|||..:.:.:..     ..:|...|:.:...:||......|...:.||.
  Fly    30 IKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVA 94

Mouse    87 AIFGFYDKKSVNTITSFCGTLHV--------------SFITPSFPTDGTHPFVIQMRPDLKGALL 137
            ||||.....:.:.:.|.|..:.:              |.:...:|    ||      ..|..|.:
  Fly    95 AIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESCLVNLYP----HP------NTLSKAYV 149

Mouse   138 SLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELK 202
            .::.::.|..|..:|:::.|:..||.:|.:.....:.:|...:    :|..|  ||.|.:.::..
  Fly   150 DIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQL----SDSGD--YRPLLKQIKNS 208

Mouse   203 KERRVILDCERDKVNDIVDQVITIGKHVKGYH-YIIANLGFTDGDLLKIQFGGANVSGFQIVDYD 266
            .|..::|||..:::::::.|...||. :..|| |::.:|.....:|.:.::||.|::||:::  :
  Fly   209 AEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI--N 270

Mouse   267 DSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDC 330
            :.:||..:.:||..|:.....|:..|::..:||.||||.:..:|..:| ..|:|:|......|..
  Fly   271 EKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQS 335

Mouse   331 LANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKM 395
                  .|..|..:...:|.|:::||:..||||..|.|.::.::|:||...|.||||.|:
  Fly   336 ------TWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWN----- 389

Mouse   396 VVTLTELPSG-NDT-----------SGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVD 448
                :.||.| |.|           :.|:|||:||||||.:||.|.|::...|.||:::|||.||
  Fly   390 ----STLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVD 450

Mouse   449 LAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS 513
            |..||:|..||.||:.:|.||.||:.:..|..||||:.||:..:||:|||.||||..||:.:||:
  Fly   451 LIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFT 515

Mouse   514 KPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFE 578
            .|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||......
  Fly   516 TPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDA 580

Mouse   579 DGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 643
            .|.:.:|     :|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:||||||||||
  Fly   581 HGEKVES-----QFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAA 640

Mouse   644 FLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708
            |||||||.|||||||||:|||.|.||.|..|||..|||.|||:.:.:||::|.||.||||..:..
  Fly   641 FLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNG 705

Mouse   709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLK 773
            |||.||.|.||.||:|:|||..||:.:|. |:..:|||.||:|.||||||..|..||.:|..:||
  Fly   706 EGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTAINSVILK 769

Mouse   774 LSEQGVLDKLKNKWWYDK---GECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835
            |.|:|.|..||.|||.:|   |:|..:.|.|....:.|.|:||.|||.:|:||:|:|.::|:.||
  Fly   770 LQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEF 834

Mouse   836 CYKSRAEAKRMKMT 849
            .:|||..|...:::
  Fly   835 VWKSRKVAVEERLS 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	98/390 (25%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	209/383 (55%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	101/399 (25%)
		ANF_receptor	42..378	CDD:279440	85/360 (24%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	206/375 (55%)
		Lig_chan	547..823	CDD:278489	150/281 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820